What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Fan, Baozhu; Jabeen, Riffat; Bo, Bing; Guo, Chunlei; Meng-jie, Han; Zhang, Hui; Cen, Juan; Ji, Xin‐Ying; Wei, Jianshe

doi:10.1155/2020/4293071

Cited by 35 publications

(17 citation statements)

References 187 publications

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“…This debilitating fear of movement can also be considered a factor that intensifies one’s limited activity levels. At all times, it is important to bear in mind that moderate physical activity has a positive impact on PD and should be used as a treatment to alleviate symptoms such as motor dysfunction, cognitive deficits, and depression [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Jiménez-Cebrián

Becerro-de-Bengoa-Vallejo

Iglesias

et al. 2021

IJERPH

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Background: Kinesiophobia can be an obstacle to physical and motor activity in patients with Parkinson’s disease (PD). PD affects patients’ independence in carrying out daily activities. It also impacts a patient’s biopsychosocial well-being. The objective of this study was to analyze the levels and scores of kinesiophobia in PD patients and compare them with healthy volunteers. Methods: We deployed a case-control study and recruited 124 subjects (mean age 69.18 ± 9.12). PD patients were recruited from a center of excellence for Parkinson’s disease (cases n = 62). Control subjects were recruited from the same hospital (control n = 62). Kinesiophobia total scores and categories were self-reported using the Spanish version of the Tampa Scale of Kinesiophobia (TSK-11). Results: Differences between cases and control groups were analyzed using the Mann–Whitney U test. Statistically significant differences (p < 0.05) were shown between groups when comparing kinesiophobia categories (or levels) and total scores, revealing higher kinesiophobia symptoms and levels in PD patients. All of the PD patients reported some degree of kinesiophobia (TSK-11 ≥ 18), while the majority of PD patients (77.3%) had kinesiophobia scores rated as moderate to severe (TSK-11 ≥ 25). On the other hand, ~45.1% of controls reported no or slight kinesiophobia and 53.2% reported moderate kinesiophobia. Conclusions: Total kinesiophobia scores were significantly higher in PD patients compared with healthy controls, with moderate to severe kinesiophobia levels prevailing in PD patients. Therefore, individuals living with PD should be evaluated and controlled in order to detect initial kinesiophobia symptoms.

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Section: Introductionmentioning

confidence: 99%

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Jiménez-Cebrián

Becerro-de-Bengoa-Vallejo

Iglesias

et al. 2021

IJERPH

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“…Furthermore, according to Fan et al [ 18 ], physical exercise, especially those performed at moderate to vigorous intensities, has a positive impact on PD through multiple mechanisms, including reduction of α-synuclein protein accumulation, decrease in inflammation and oxidative stress, improvement in brain-derived neurotrophic factor (BDNF) activity, nerve regeneration, and mitochondrial function. Furthermore, some authors have shown that endurance exercise is safe and well-tolerated for people with PD from a cardiovascular point of view, which supports their recommendation for this population [ 19 ].…”

Section: Introductionmentioning

confidence: 66%

Effect of the combination of automated peripheral mechanical stimulation and physical exercise on aerobic functional capacity and cardiac autonomic control in patients with Parkinson’s disease: a randomized clinical trial protocol

Zelada-Astudillo

Moreno

Herrera-Santelices

et al. 2021

Trials

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Background Automated peripheral mechanical stimulation (AMPS) has been proposed as a new complementary therapy with potential for improving motor and cardiovascular abnormalities in Parkinson’s disease (PD). However, AMPS long-term effects and its combination with physical exercise are unknown. Thus, this study aims to compare the effects of a program of 12 weeks of physical exercise with a 12-week intervention program combining physical exercise and AMPS on the aerobic capacity, cardiac autonomic control, and gait parameters in patients with PD. Methods A randomized, controlled clinical trial will be conducted. Older volunteers with PD will be randomly assigned to one of the two groups studied: (1) exercise or (2) AMPS + exercise. Both groups will undergo an exercise program of 24 sessions, for 12 weeks, performed twice a week. Before exercise sessions, the group AMPS + exercise will receive a session of active AMPS, while the group exercise will receive an AMPS sham intervention. Shapiro-Wilk’s and Levene’s tests will be used to check for data normality and homogeneity, respectively. In case parametric assumptions are fulfilled, per-protocol and intention-to-treat analyses will be performed using a mixed model analysis of variance to check for group*time interaction. Significance level will be set at 5%. Discussion Several non-pharmacological treatment modalities have been proposed for PD, focusing primarily on the reduction of motor and musculoskeletal disorders. Regular exercise and motor training have been shown to be effective in improving quality of life. However, treatment options in general remain limited given the high prevalence and adverse impact of these disorders. So, developing new strategies that can potentiate the improvement of motor disabilities and also improve non-motor symptoms in PD is relevant. It is expected that the participants from both groups will improve their quality of life, gait parameters, and their cardiac autonomic control, with greater improvements being observed in the group combining active AMPS and physical exercise. Trial registration ClinicalTrials.gov NCT04251728. Registered on February 05, 2020.

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“…In a literature review conducted by Fan et al, studies demonstrated the positive effects of the variety of symptoms seen in PD through several mechanisms including reduction of accumulated alpha synuclein protein, alleviating inflammation and oxidative stress, enhancing BDNF activity, nerve regeneration and improving mitochondrial function. 31…”

Section: Methodsmentioning

confidence: 99%

The Role of Exercise in Parkinson’s Disease

Emig

George

Zhang

et al. 2021

J Geriatr Psychiatry Neurol

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Parkinson’s disease (PD) is a progressive, neurodegenerative disorder of the central nervous system. While it primarily affects motor function, patients eventually develop non-motor symptoms including depression, anxiety, and eventually dementia. Although there is currently no cure, treatment is aimed largely at improving quality of life though medication or surgical techniques to reduce motor symptoms. However, there is vast evidence of the benefits of physical activity as adjunct therapy for Parkinson’s disease. In this review, we analyze 31 studies or reviews and highlight the role of exercise and rehabilitation in PD treatment. This study serves to provide clinicians with a comprehensive resource of the wide variety of exercises with proven benefit for patients affected by Parkinson’s disease. Specifically, patients report significant improvements in motor function, cognition, mood and sleep habits.

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What and How Can Physical Activity Prevention Function on Parkinson’s Disease?

Cited by 35 publications

References 187 publications

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Kinesiophobia Levels in Patients with Parkinson’s Disease: A Case-Control Investigation

Effect of the combination of automated peripheral mechanical stimulation and physical exercise on aerobic functional capacity and cardiac autonomic control in patients with Parkinson’s disease: a randomized clinical trial protocol

The Role of Exercise in Parkinson’s Disease

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