Association between pet‐keeping and asthma in school children

Medjo, Biljana; Atanasković-Marković, Marina; Nikolić, Dimitrije; Brankica, Spasojevic-Dimitrijeva; Ivanovski, Petar; Djukić, Slobodanka

doi:10.1111/ped.12071

Cited by 21 publications

(23 citation statements)

References 21 publications

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“…Levels of allergens can vary by pet inhabitancy 28,29. There was no difference in Fel d 1 level between houses with cats and houses without; however, the results may be due to the small sample size of only 2 houses with cats.…”

Section: Discussionmentioning

confidence: 72%

A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea

Park

Lee

Ann

et al. 2014

Allergy Asthma Immunol Res

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PurposeThe higher prevalence of respiratory allergic disease may be due to increased exposure to inhalation allergens. We conducted a survey of allergic diseases in autumn and winter with detection of major indoor allergens in major cities in Korea.MethodsWe enrolled 110 subjects from the fourth Korea National Health and Nutrition Examination Survey with stratified, cluster, and systematic sampling procedures. All participants answered a health questionnaire as well as underwent a skin prick test (SPT) and ImmunoCAP for 11 indoor major allergens. We also measured the levels of 5 major allergens (Der f 1, Der p 1, Can f 1, Bla g 1, and Asp f 1) in fine indoor dust from the houses of 60 subjects with a 2-site ELISA.ResultsThe prevalence of allergic rhinitis and asthma were 25.5% and 7.3%, respectively. The most common sensitized allergens identified by SPT and ImmunoCAP were Dermatophagoides farinae (40.9%, 36.8%), followed by cockroach (23.6%, 19.5%), mugwort (13.6%, 22.9%), oak (9.1%, 22.9%), Japanese hop (9.1%, 8.6%), and dog dander (8.2%, 6.9%). There was a modest discrepancy between SPT and ImmunoCAP. Der f 1 and Der p 1 were detected in 91.7% and 45.0% of the enrolled houses, respectively. Der f 1 indicated high concentrations in all specific provinces in Korea; however, Der p 1 measured high only in the south. Dog dander allergens were present in 71.7% of houses; however, Bla g 1 was present in only 11.7% of houses and Asp f 1 was not detected in any houses.ConclusionsThe most important inhalant allergens in Korea are house dust mites followed by cockroach, mugwort, oak, Japanese hop, and dog dander in indoor environment, in which The dominant species of house dust mites were different according to region.

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Section: Discussionmentioning

confidence: 72%

A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea

Park

Lee

Ann

et al. 2014

Allergy Asthma Immunol Res

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“…While some studies suggest that pet exposure is associated with a higher risk of asthma, 2,[9][10][11] others suggest a lower asthma risk in exposed individuals. 15 Sensitization to inhalant allergens is considered an important risk factor for the development of asthma 16 and exposure to pets in early life has been consistently associated with lower risk of sensitization during childhood, 1,14,17 but it is unknown whether this inverse relationship persists into adolescence and whether exposure during other periods is relevant. 14 Another study investigated associations of pet exposure during different periods of childhood with asthma and also found no association of early, past and current pet exposure with asthma in schoolchildren.…”

Section: Introductionmentioning

confidence: 99%

Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

Milanzi

Koppelman

Smit

et al. 2019

Clin Experimental Allergy

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Background: Pet and dampness or mould exposure are considered risk factors for asthma and sensitization. It is unclear whether timing of exposure to these factors is differentially associated with asthma risk and sensitization in adolescence. Objective:We investigated the role of timing of pet and dampness or mould exposure in asthma and sensitization in adolescence. Understanding this role is essential to build targeted prevention strategies. Methods: We used data from 1871 participants of the Dutch Prevention andIncidence of Asthma and Mite Allergy (PIAMA) cohort. Residential exposure to pets, dampness or mould was assessed by repeated parental questionnaires. We used asthma data from the 17-year questionnaire and sensitization data from the 16-year medical examination. We characterized timing using longitudinal exposure patterns from pregnancy till age 17 using longitudinal latent class growth modelling. We used logistic regression models to analyse associations of exposure patterns with asthma at age 17 and sensitization at age 16.Results: For none of the time windows, exposure to pets and dampness or mould was associated with asthma at age 17, but a lower sensitization risk at age 16 was suggested, for example the odds ratio (95% confidence interval) for sensitization was 0.63 (0.35-1.11) and 0.69 (0.44-1.08) for early life and persistently high pet exposure, respectively, compared with very low exposure. An inverse association was also suggested for sensitization and moderate early childhood dampness or mould exposure (0.71 [0.42-1.19]). Conclusion and clinical relevance:Different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation. Current findings are not sufficient to recommend pet avoidance to prevent allergic disease.More prospective studies are needed to obtain insights that can be used in clinical practice. K E Y W O R D Sadolescence, asthma, dampness and mould, pets, sensitization | 1353 MILANZI et AL.

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“…Families that avoid keeping pets due to familial history of allergies have been shown to have higher risks of developing asthma and allergy compared to families without this pet-avoidance behavior, inferring that pet-keeping may have a protective effect. 6,10,[15][16][17] In the present study, we did not account for this "healthy pet-keeping effect," which may have under-or overestimated the association seen between pet-keeping and the risk of asthma and allergy in children. However, some studies have shown that parental asthma did not modify the effect of exposure to dogs or farm animals on the risk of asthma in childhood, and pet avoidance may not be a major factor.…”

Section: S Tudy S Treng Th S and Limitati On Smentioning

confidence: 87%

“…10 Others have also suggested that the effect of pet ownership may be related to the prevalence of pet-keeping and community exposure to pet allergens such that those without pets benefit from passive exposure. 15 As such, counseling for lifestyle modifications could be important, more so for families with a genetic predisposition to asthma and allergy. 20 We did not assess these factors in the current study.…”

Section: S Tudy S Treng Th S and Limitati On Smentioning

confidence: 99%

Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy

Ojwang

Nwaru

Takkinen

et al. 2020

Pediatric Allergy Immunology

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Background: Synergistic role of exposure to cats, dogs, and farm animals during infancy on the risk of childhood asthma and allergy remains unknown. Objectives:To investigate independent and synergistic associations between exposure to indoor pets and farm animals during infancy and the risk of asthma and allergy by age 5. Methods: We studied 3781 children participating in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. At age 5, a validated version of the International Study of Asthma and Allergies in Childhood questionnaire was administered to collect

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Association between pet‐keeping and asthma in school children

Cited by 21 publications

References 21 publications

A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea

A Nationwide Survey of Inhalant Allergens Sensitization and Levels of Indoor Major Allergens in Korea

Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy

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