Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

Milanzi, Edith B.; Koppelman, Gerard H.; Smit, Henriëtte A.; Wijga, Alet H.; Vonk, Judith M.; Brunekreef, Bert; Gehring, Ulrike

doi:10.1111/cea.13471

Cited by 9 publications

(9 citation statements)

References 55 publications

(106 reference statements)

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“…This aligns well with other data on molecular allergy diagnostics to refine characterization of sensitization 3 and basophil activation testing in the diagnosis of dog allergy in children 4 . The importance of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence has also been reported in this year's Clinical and Experimental Allergy 5 . Findings were that different timing of pet and dampness or mould exposure was not associated with asthma, but lower risk of sensitization in adolescence was suggested, which could be partly attributable to reversed causation.…”

Section: Epidemiologysupporting

confidence: 83%

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

Roberts

Almqvist

Boyle

et al. 2020

Clin Experimental Allergy

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In the second of two linked articles, we describe the development in clinical as described by Clinical & Experimental Allergy and other journals in 2019. Epidemiology, clinical allergy, asthma and rhinitis are all covered. In this article, we described the development in the field of allergy as described by Clinical and Experimental Allergy in 2019. Epidemiology, clinical allergy, asthma and rhinitis are all covered.

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Section: Epidemiologysupporting

confidence: 83%

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

Roberts

Almqvist

Boyle

et al. 2020

Clin Experimental Allergy

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“…Most previous studies have assessed the associations of cat and dog exposure with allergic disorders, and the reported associations have been contradictory (16,17,34,35). Our results showed that cat-keeping was associated with asthma and rhinitis symptoms, as well as ever doctor-diagnosed eczema.…”

Section: Discussionmentioning

confidence: 54%

Pet-Keeping in Relation to Asthma, Rhinitis, and Eczema Symptoms Among Adolescents in Kuwait: A Cross-Sectional Study

AlShatti

Ziyab

2020

Front. Pediatr.

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Background: Findings on the associations between household pet-keeping and allergic diseases, including asthma, rhinitis, and eczema, have been contradictory, with investigations reporting positive, negative, and null associations. This study sought to estimate the prevalence of pet-keeping among families in Kuwait and to assess the associations between pet-keeping and symptoms of allergic diseases among adolescents. Methods: Schoolchildren aged 11-14 years (n = 3,864) were enrolled in this cross-sectional study. The children's parents completed questionnaires regarding their child's environmental exposures, including pet-keeping in the past 12 months, and clinical history and symptoms of allergic diseases. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and their 95% confidence intervals (CIs) were estimated. Results: Pet-keeping in the past 12 months was reported by 42.8% of the participating families. Birds, cats, rabbits, fish, and dogs were kept by 28.3, 13.2, 7.8, 3.9, and 3.1% of all households, respectively. Current cat ownership was significantly associated with current wheezing (aPR 1.29, 95% CI 1.05-1.58), current rhinitis symptoms (aPR 1.18, 95% CI 1.02-1.36), and ever doctor-diagnosed eczema (aPR 1.25, 95% CI 1.03-1.50). Current rabbit-keeping was positively associated with multiple symptoms of asthma (e.g., study-defined current asthma: aPR 1.38, 95% CI 1.04-1.82) and eczema (e.g., severe eczema: aPR 1.94, 95% CI 1.02-3.71). Similarly, current bird-keeping was associated with study-defined current rhinitis (aPR 1.19, 95% CI 1.05-1.41) and current itchy rash (aPR 1.27, 95% CI 1.10-1.46). Conclusions: Household pet-keeping is very common and diverse in Kuwait and was found to be positively associated with symptoms of allergic diseases among adolescents. The findings of associations between rabbit-keeping and symptoms of asthma and eczema add to the existing literature and further highlight the importance of considering the pet type when assessing such associations.

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“…In the Swedish BAS cohort, keeping cats in the 1 st year of life turned out to be protective with regard to the development of allergic rhinitis at 13 years of age, but these data are based on parent questionnaire and not on a physician’s diagnosis [ 169 ]. In a large Dutch study, no association was found between pet exposure in childhood and bronchial asthma at 17 years of age [ 170 ]. It remains to be seen whether keeping a dog should be explicitly recommended for families as a primary allergy prevention.…”

Section: Discussionmentioning

confidence: 99%

“…The existing studies are cross-sectional analyzes that were carried out on the basis of information provided by parents. The study by Milanzi et al [ 170 ] (n = 1,871) shows no association between mold/moisture at different time points in childhood and the development of asthma. In contrast, another paper (n = 4,089) shows that exposure to mold and moisture directly correlates with the risk of developing asthma.…”

Section: Discussionmentioning

confidence: 99%

S3 Guideline Allergy Prevention

Kopp¹,

Muche-Borowski²,

Abou-Dakn³

et al. 2022

ALS

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Background: The persistently high prevalence of allergic diseases in Western industrial nations and the limited possibilities of causal therapy make evidence-based recommendations for primary prevention necessary. Methods: The recommendations of the S3 guideline Allergy Prevention, published in its last version in 2014, were revised and consulted on the basis of a current systematic literature search. The evidence search was conducted for the period 06/2013 – 11/2020 in the electronic databases Cochrane and MEDLINE, as well as in the reference lists of current reviews and through references from experts. The literature found was screened in two filtering processes, first by title and abstract, and the remaining papers were screened in the full text for relevance. The studies included after this were sorted by level of evidence, and the study quality was indicated in terms of potential bias (low/high). The revised recommendations were formally agreed and consented upon with the participation of representatives of the relevant professional societies and (self-help) organizations (nominal group process). Of 5,681 hits, 286 studies were included and assessed. Results: Recommendations on maternal nutrition during pregnancy and breastfeeding as well as on infant nutrition in the first months of life again play an important role in the updated guideline: Many of the previous recommendations were confirmed by the current data. It was specified that breastfeeding should be exclusive for the first 4 – 6 months after birth, if possible, and that breastfeeding should continue with the introduction of complementary foods. A new recommendation is that supplementary feeding of cow’s milk-based formula should be avoided in the first days of life if the mother wishes to breastfeed. Furthermore, it was determined that the evidence for a clear recommendation for hydrolyzed infant formula in non-breastfed infants at risk is currently no longer sufficient. It is therefore currently recommended to check whether an infant formula with proven efficacy in allergy prevention studies is available until the introduction of complementary feeding. Finally, based on the EAACI guideline, recommendations were made for the prevention of chicken egg allergy by introducing and regularly giving thoroughly heated (e.g., baked or hard-boiled) but not “raw” chicken egg (also no scrambled egg) with the complementary food. The recommendation to introduce peanut in complementary feeding was formulated cautiously for the German-speaking countries: In families who usually consume peanut, the regular administration of peanut-containing foods in age-appropriate form (e.g., peanut butter) with the complementary diet can be considered for the primary prevention of peanut allergy in infants with atopic dermatitis (AD). Before introduction, a clinically relevant peanut allergy must be ruled out, especially in infants with moderate to severe AD. There is still insufficient evidence for an allergy-pre...

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Role of timing of exposure to pets and dampness or mould on asthma and sensitization in adolescence

Cited by 9 publications

References 55 publications

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

Pet-Keeping in Relation to Asthma, Rhinitis, and Eczema Symptoms Among Adolescents in Kuwait: A Cross-Sectional Study

S3 Guideline Allergy Prevention

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