Association Between Periodontitis and Hyperlipidemia: Cause or Effect?

Cutler, Christopher W.; Shinedling, Edward A.; Nunn, Martha E.; Jotwani, Ravi; Kim, Byung Ock; Nares, Salvador; Iacopino, Anthony M.

doi:10.1902/jop.1999.70.12.1429

Cited by 192 publications

(250 citation statements)

References 27 publications

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“…In addition, chewing ability may be an independent predictor of physical fitness measurements in the elderly (5 (2). This is supported by recent investigations, which found associations between impaired lipid metabolism and periodontal disease (6)(7)(8)(9)(10). Furthermore, atherosclerotic diseases such as cardiovascular diseases have recently been associated with periodontal disease (11,12).…”

Section: Periodontitis Has Been Referred To As the Sixth Complicationmentioning

confidence: 74%

“…Periodontal tissue damage may thus be more expected in diabetics with hypercholesteremia, as found in our study. Some (6,9) but not all (7,10,(14)(15)(16)20) previous studies have associated hypercholesteremia with periodontal disease.…”

Section: T a B L E 1 Ch A R A C T E R I S T I C S O F S T U D Y S Umentioning

confidence: 98%

“…Whether atherogenic factors other than hyperglycemia are linked with periodontal damage, however, is still being debated, and previous studies have reported inconsistent results (6)(7)(8)(9)(10)(13)(14)(15)(16)(17)(18)(19)(20)(21) …”

Section: Periodontitis Has Been Referred To As the Sixth Complicationmentioning

confidence: 99%

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Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

et al. 2007

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Section: Periodontitis Has Been Referred To As the Sixth Complicationmentioning

confidence: 74%

Section: T a B L E 1 Ch A R A C T E R I S T I C S O F S T U D Y S Umentioning

confidence: 98%

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Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

et al. 2007

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“…Recently, studies examining the relationship between periodontal disease and hyperlipidemia have shown that a greater systemic involvement may occur in patients exhibiting periodontal involvement (1)(2)(3)(4). Chronic exposure to bacterial lipopolysaccharides (LPS) can promote recruitment of defense cells which secrete alpha tumor necrosis factor (TNF-α) and interleukin-1 beta (IL-1β), thus increasing lipogenesis and lipolysis.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Zuza¹,

Barroso²,

Fabricio³

et al. 2016

Journal of Oral Science

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Periodontal treatment may improve the metabolic control of dyslipidemia. The aim of this study was to evaluate the lipid profile and high-sensitivity C-reactive protein (hs-CRP) levels in obese and non-obese patients undergoing periodontal therapy. Patients with generalized chronic periodontitis were divided into obese (n = 28) and non-obese groups (n = 26). The periodontal parameters (visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing), anthropometric measurements (body mass index, waist circumference, and body fat), and serum analyses (triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, fasting glucose, glycated hemoglobin, and hs-CRP) were measured at baseline and 90 days after periodontal treatment. The results showed that the obese subjects presented alterations in triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP at baseline when compared with non-obese patients (P < 0.05). Periodontal treatment could improve the periodontal parameters in both groups similarly (P > 0.05). Obese subjects showed a significant decrease in the levels of triglycerides, total cholesterol, low-density lipoprotein, and hs-CRP post-therapy (P < 0.05), while non-obese patients showed improvement only in hs-CRP (P < 0.05). In conclusion, periodontal treatment could improve the periodontal parameters and circulating hs-CRP in obese and non-obese subjects. Lipid profile was modified only in obese patients post-therapy. (J Oral Sci 58, [423][424][425][426][427][428][429][430] 2016)

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“…CP patients have elevated local levels of both Th2-and Th1-biasing cytokines (reviewed in [13,14]) and increased local numbers of DC subpopulations [15][16][17][18][19], CD4 + T cells [13][14][15][16] and B cells / plasma cells [14,20]. Many reports cite the induction of a strong humoral immune response towards P. gingivalis in adult periodontitis subjects (reviewed in [21]), including evidence for induction of high IgG antibodies to P. gingivalis LPS [22], with elevated IgG4 [23,24]. The lack of clear polarization in the cytokine response in CP [13] might be 4, and treated with indicated doses of LPS for 24 h. Culture supernatants were collected and assayed for IL-12 p70 and IP-10 by commercial ELISA (IL-10) and by CBA kit (IL-12 p70).…”

Section: Introductionmentioning

confidence: 99%

Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro

et al. 2003

Self Cite

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Understanding how mucosal pathogens modulate the immune response may facilitate the development of vaccines for disparate human diseases. In the present study, human monocyte-derived DC (MDDC) were pulsed with LPS of the oral pathogen Porphyromonas gingivalis and Escherichia coli 25922 and analyzed for: (i) production of Th-biasing/inflammatory cytokines; (ii) maturation/costimulatory molecules; and (iii) induction of allogeneic CD4 + and naive CD45RA + T cell proliferation and release of Th1 or Th2 cytokines. We show that E. coli LPS-pulsed MDDC released Th1-biasing cytokines -consisting of high levels of IL-12 p70, IFN-+ -inducible protein 10 (IP-10) -but also TNF- § , IL-10, IL-6 and IL-1 g . In contrast, no IL-12 p70 or IP-10, and lower levels of TNF- § and IL-10 were induced by P. gingivalis LPS. These differences were sustained at LPS doses that yielded nearly equivalent maturation of MDDC; moreover the T cell response was consistent: E. coli LPS-pulsed MDDC induced higher T cell proliferation, and T cells released more IFN-+ and IL-2, but less IL-5 than T cells co-cultured with P. gingivalis LPS pulsed-MDDC. IL-13 was secreted by naive CD45RA + CD45RO -CD4 + T cells in response to P. gingivalisLPS-pulsed MDDC. These results suggest that human MDDC can be polarized by LPS from the mucosal pathogen P. gingivalis to induce a Th2 effector response in vitro.

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Association Between Periodontitis and Hyperlipidemia: Cause or Effect?

Cited by 192 publications

References 27 publications

Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

Associations of Periodontal Damage and Tooth Loss with Atherogenic Factors among Patients with Type 2 Diabetes Mellitus

Lipid profile and high-sensitivity C-reactive protein levels in obese and non-obese subjects undergoing non-surgical periodontal therapy

Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting a Th2 effector response in vitro

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