Association between periodontitis and glycated hemoglobin levels in individuals living in rural Southern Brazil

Tavares, Rodrigo da Cunha Rossignollo; Ortigara, Gabriela Barbieri; Tatsch, Karen Finger; Ferreira, Ciandra Miraglia; Boligon, Jociana; Moreira, Carlos Heitor Cunha

doi:10.1007/s00784-021-03980-y

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…It has the advantages of simple operation and wide application. However, with the significant development of human diseases and the improvement of medical technology, the effect of traditional electrocardiogram still needs to improve [ 26 – 29 ]. ECG vector chart can effectively record the size and direction of electrical signals generated by the heart, effectively eliminate all kinds of heart diseases except arrhythmia, and truly and effectively describe the stereoscopic image of heart activity.…”

Section: Discussionmentioning

confidence: 99%

The Combination Clinical Value of Plasma Brain Natriuretic Peptide and Serum HbAlc in the Diagnosis of Chronic Pulmonary Heart Disease

Jia¹

2022

Computational and Mathematical Methods in Medicine

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Objective. To analyze the combination clinical value of plasma brain natriuretic peptide and serum glycated hemoglobin (HbAlc) in chronic pulmonary heart disease. Methods. A total of 200 patients with chronic pulmonary heart disease admitted to our hospital from January 2021 to January 2022 were selected as the observation group, and 200 healthy subjects were selected as the control group during the same period. All subjects were examined by an ECG vector map and plasma BNP, and HbAlc levels were detected to analyze the value and clinical significance of each index in single diagnosis and combined diagnosis. Results. Plasma BNP and HbAlc levels in the observation group were significantly higher than those in the control group ( P < 0.05 ). There were 154 BNP positive, 146 HbAlc positive, 164 parallel combined diagnosis positive, and 132 serial combined diagnosis positive. Sensitivity of series combination diagnosis was significantly higher than other indexes ( P < 0.05 ); especially, parallel combination diagnosis was significantly higher than other indexes ( P < 0.05 ). Besides, area under the ROC curve of parallel combination diagnosis and series combination diagnosis was significantly higher than that of each index alone diagnosis ( P < 0.05 ). Conclusion. In the diagnosis of chronic pulmonary heart disease, the combination of plasma BNP and HbAlc can effectively improve the diagnostic specificity and sensitivity, as well as improve the area under the ROC curve.

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Section: Discussionmentioning

confidence: 99%

The Combination Clinical Value of Plasma Brain Natriuretic Peptide and Serum HbAlc in the Diagnosis of Chronic Pulmonary Heart Disease

Jia¹

2022

Computational and Mathematical Methods in Medicine

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“…The literature supports the association with periodontitis and certain systemic diseases [15] . It affects around 50% of the world population, 64% of which are people over 65 years of age [16] . Systemic pathologies such as autoimmune diseases, diabetes mellitus, Alzheimer's disease, inflammatory diseases, and oral cancer have been identified as being of reciprocal importance in periodontal disease [17] .…”

Section: Prevalencementioning

confidence: 99%

The use of oral probiotics in non-surgical periodontal therapy: Literature Review

Pulido¹,

Cantu²,

Franco³

et al. 2023

Int. J. Appl. Dent. Sci.

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Periodontal disease is a chronic disease that develops through multiple factors. It is directly associated with the accumulation of biofilm. It is characterized by progressive destruction of the supporting tissues of the teeth. Clinically it can be diagnosed through parameters that are gingival inflammation, loss of clinical attachment, increased probing depth, bleeding on probing, and dental mobility. The figures that have been found are around 1.1 billion cases of severe periodontal disease, in 2019. These amounts are equivalent to 15% of the world population. Radio graphically, vertical, horizontal, or both bone loss may be seen. Periodontal therapy is based on five phases: systemic, hygienic, surgical, restorative and maintenance. Currently, adjuvants to periodontal therapy have been found with favorable results. Oral probiotics, the Lactobacillus strain specifically, have been studied in non-surgical periodontal therapy. It has been shown that in patients with gingivitis plus the use of probiotics and periodontal mechanical therapy, patients have a reduction in the previously mentioned clinical parameters. On the other hand, there are also prebiotics that are non-pathogenic bacteria, their function is to improve the health of the host. This is how systemic homeostasis through vitamins and food, proposes a lower risk of developing periodontal disease.

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“…Several studies have demonstrated that periodontitis is associated with elevated high-sensitivity C-reactive protein (hs-CRP) 19 and glycated hemoglobin (HbA1c) levels, 20,21 and with chronic systemic diseases. These associations may be partially explained by shared genetic risk factors; however, knowledge is still limited.…”

mentioning

confidence: 99%

Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016

Asa’ad

Petrenya

Jönsson

et al. 2023

Journal of Periodontology

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BackgroundThe aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high‐sensitivity C‐reactive protein (hs‐CRP), and glycated hemoglobin (HbA1c) levels.MethodsWe included participants with periodontal examination (n = 3633, aged: 40–93 years) from the Tromsø Study seventh survey (2015–2016), Norway. Periodontitis was defined according to the 2017 AAP/EFP classification system as no periodontitis, grades A, B, or C. Salivary DNA was extracted and genotyping was performed to investigate four SNPs (rs2288349, rs35474715, rs34023346, and rs10010325) in the sequence of the genes DNMT1, IDH2, TET1, and TET2. Association between SNPs and periodontitis was analyzed by logistic regression adjusted for age, sex, and smoking. Subgroup analyses on participants aged 40–49 years were performed.ResultsIn participants aged 40‐49 years, homozygous carriage of minor A‐allele of rs2288349 (DNMT1) was associated with decreased susceptibility to periodontitis (grade A: odds ratio [OR] 0.55; p = 0.014: grade B/C OR 0.48; p = 0.004). The minor A‐allele of rs10010325 (TET2) was associated with increased susceptibility to periodontitis (grade A OR 1.69; p = 0.035: grade B/C OR 1.90; p = 0.014). In the entire sample, homozygous carriage of the G‐allele of rs35474715 (IDH2) was associated with having ≤24 teeth (OR 1.31; p = 0.018). Homozygous carriage of the A‐allele of TET2 was associated with hs‐CRP≥3 mg/L (OR 1.37; p = 0.025) and HbA1c≥6.5% (OR 1.62; p = 0.028).ConclusionsIn this Norwegian population, there were associations between polymorphism in genes related to DNA methylation and periodontitis, tooth loss, low‐grade inflammation, and hyperglycemia.

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Association between periodontitis and glycated hemoglobin levels in individuals living in rural Southern Brazil

Cited by 5 publications

References 32 publications

The Combination Clinical Value of Plasma Brain Natriuretic Peptide and Serum HbAlc in the Diagnosis of Chronic Pulmonary Heart Disease

The Combination Clinical Value of Plasma Brain Natriuretic Peptide and Serum HbAlc in the Diagnosis of Chronic Pulmonary Heart Disease

The use of oral probiotics in non-surgical periodontal therapy: Literature Review

Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high‐sensitivity C‐reactive protein and glycated hemoglobin: The Tromsø Study 2015‐2016

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