Association between Patients’ Knowledge and Adherence to Anticoagulants, and Its Effect on Coagulation Control

Ahmed, Hazem A. Sayed; Saddouh, Enas Ahmed; Abugrin, Mohamed; Ali, Alya Muftah Mohammed; Elgdhafi, Elham Omran; Khaled, Ala; Tarek, Ahmed; Elhadi, Muhammed

doi:10.1159/000511754

Cited by 6 publications

(13 citation statements)

References 63 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, with vitamin K antagonists, monitoring of the therapeutic window is required. Ahmed et al 1289 , recently pointed out the additional challenge with warfarin in a study focusing on patient's knowledge and adherence to anticoagulants and their effect on outcomes. The overall adherence to warfarin was 76.2%.…”

Section: -Are There Differences Between Various Venous Thromboembolis...mentioning

confidence: 99%

Recommendations from the ICM-VTE: General

2022

Journal of Bone and Joint Surgery

View full text Add to dashboard Cite

show abstract

Section: -Are There Differences Between Various Venous Thromboembolis...mentioning

confidence: 99%

Recommendations from the ICM-VTE: General

2022

Journal of Bone and Joint Surgery

View full text Add to dashboard Cite

show abstract

“…A total of 2763 records were retrieved after running the initial search. Overall, 12 studies [9,[19][20][21][22][23][24][25][26][27][28][29] met the inclusion criteria of this systematic review, being selected for synthesis. A manual search was performed, with no identification of any study meeting the eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Among the selected studies, there were different results regarding the relationship between the variables analyzed. Seven [9,19,[21][22][23][24][25] studies indicated a significant association between the patient level of knowledge on warfarin therapy and TTR, whereas five [20,[26][27][28][29] studies did not indicate statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the relationship between the level of patient knowledge on warfarin therapy and the quality of oral anticoagulation: A systematic review and meta-analysis

et al. 2023

View full text Add to dashboard Cite

The present study aimed to investigate the relationship between the level of patient knowledge on warfarin therapy and the quality of oral anticoagulation. This is a systematic review and meta-analysis written on the basis of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Searches at MEDLINE, EMBASE, Scopus and LILACS electronic databases were carried out on February 13, 2023, using the descriptors "Patient Medication Knowledge", "Patient Education as Topic", "Health Education", "Patient Education" and Warfarin. The steps of selection, data extraction and quality analysis of articles were performed independently by two reviewers. The analysis was performed considering patient knowledge as a possible modifier of time in therapeutic range (TTR). The meta-analysis included studies that reported the correlation coefficient (Pearson or Spearman) between patient knowledge and TTR. A subgroup analysis was performed according to questionnaires employed to measure patient knowledge. Twelve studies were selected with an overall sample size of 7634 participants and mean age 58.2 (standard deviation (SD)±12,8) years. Eleven (92.0%) cross-sectional studies. The mean TTR was 57.8% (SD±11,3%) and the average level of knowledge was 60.4%. The meta-analysis indicated that patient level of knowledge on warfarin therapy was moderately associated with TTR (rs = 0.435; 95% confidence interval (CI) = 0.163–0.645; I2 = 96%). Subgroup analysis indicated association between knowledge level and TTR in studies employing the OAK test (rs = 0.617; 95% CI = 0.192–0.847; I2 = 97%) and the AKA (rs = 0.269; 95% CI = 0.002 to 0.501; I2 = 94%). However, the subgroup analysis presented no significant difference between them (p = 0.14). The meta-regression showed a non-significant negative effect of age on the correlation (estimate = -0.028, 95% CI = -0.073 to 0.016, p = 0.207). No publication bias was noted (p = 0.881). To our knowledge, this is the first systematic review and meta-analysis gathering evidence about the relationship between the level of patient knowledge on oral anticoagulation with warfarin and TTR. The implementation of structured and patient-centered educational interventions is essential to effectively increase the level of patient knowledge and, thus, to improve the quality and safety of warfarin therapy. Systematic review registration number: PROSPERO CRD42023398030.

show abstract

“…The correlation between medication adherence and TTR as a measure of INR control was found to be statistically significant and positive. 19…”

Section: Discussionmentioning

confidence: 99%

“…A total of 66 patients were randomly enrolled in the study out of which 50% (33) were assigned to control group and 50% (33) were into intervention group. Out of 66 patients, in control 57.6% (19) were males and 42.4% (14) were females. Whereas, in intervention 54.5% (18) were males and 45.5% (15).…”

Section: Demographic Datamentioning

confidence: 93%

Effect of Knowledge on Medication Adherence and INR Control Among Patients on Oral Anticoagulants: A Randomized Controlled Trial

Anand¹,

Avvaru²,

Deshpande³

et al. 2023

J Young Pharm.

View full text Add to dashboard Cite

Background: Anticoagulants must be provided with careful monitoring and adjusted individual dose due to their narrow therapeutic index due to significant risk of medication-drug interactions, drug-food interactions, and adverse drug reactions. Regular monitoring of INR, adequate knowledge and adherence to oral anticoagulant therapy plays a vital role in achieving better therapeutic outcomes. Thus, our study aims to assess level of adherence and knowledge of the patients. Materials and Methods: A prospective interventional study, enrolled 66 patients (control 33) and intervention (33) of both IPD (Inpatient Department) or OPD (Outpatient Department) patients with thromboembolic disorders between the age of 18-65 years and who were on oral anti-coagulant therapy. Utilization of Morisky medication adherence scale (MMAS-8) and Oral Anticoagulant Knowledge (OAK) questionnaire to assess adherence and knowledge on oral anti coagulation therapy. Results: Out of 66 patients, 56.1% male patients predominate over the 43.9% female patients, most of them were of age between 41-50 years. Majority of the patients of the intervention group were highly adhered (27.3%), moderately adhered (51.5%) and have adequate knowledge (90.9%) at follow ups after providing pharmaceutical care. Therapeutic INR has been improved among 36.4% patients. Most common cause for non-adherence is forgetfulness. Conclusion: Collaboration with clinical pharmacists can increase anticoagulant adherence and provide necessary information. Anticoagulant clinics run by pharmacists have shown to be helpful in managing anticoagulation treatment for both hospitalized and outpatient patients.

show abstract

Association between Patients’ Knowledge and Adherence to Anticoagulants, and Its Effect on Coagulation Control

Cited by 6 publications

References 63 publications

Recommendations from the ICM-VTE: General

Recommendations from the ICM-VTE: General

Assessment of the relationship between the level of patient knowledge on warfarin therapy and the quality of oral anticoagulation: A systematic review and meta-analysis

Effect of Knowledge on Medication Adherence and INR Control Among Patients on Oral Anticoagulants: A Randomized Controlled Trial

Contact Info

Product

Resources

About