Association between Paternal Age at Birth Time and the Risk of Offspring Developing Schizophrenia

Abstract

Schizophrenia is the Leading psychotic disorder. It is a severe disease that involves social and interpersonal relationship of affected person and cause severe loss of function; that why many researchers wanted to know its etiologic factors. In this research, we wanted to reveal the relationship of paternal age to schizophrenia. This cross-sectional study was done on 240 patients of schizophrenia and 400 control person without any psychiatric and organic disorders. The average of paternal age at birth in schizophrenic group was 33.9±8.4 years and that of control group was 32.7±8.3 years (P = 0.04). In this study we concluded that the average of paternal age birth in schizophrenic patients was significantly higher than age of control group. This significancy show that schizophrenia, at least in part, is related to new mutations that originate in male germ cells. And this result can change our strategies to find the genetically etiology of schizophrenia and shows that father,s age no loss than mother's contributes variably to the risk of a suboptimal reproductive outcome.

Relationship of Advanced Paternal Age and Onset of Schizophrenia

“…A study was done by Colombia university researchers on 87,907 cases, showed that the prevalence in offspring whose father were age 45-49 years is twice in comporison with who are under 25 and in fathers aged who are up to 50 years is triple than who are under 25 year. This study shows that 26.6 percent of all schizophrenia is a stronger relationship to paternal age, while there is no relation for maternal transmission of the disease [8].…”

“…Many studies suggested declared the relationship between advanced paternal age and prevalence of schizophrenia in a family, in these survey the linear correlation. More than half a century ago, a study conducted by the Book suggested that de novo mutation might cause genitival defect contributed responsibility of schizophrenia disorder, and also it is observed that increased paternal age is associated with de novo mutation [8].…”

Advanced Paternal Age and the Risk of Schizophrenia: A Literature Review

“…11 Victoria et al performed a cross-sectional study on 240 patients and 400 controls without any psychiatric disorders and found that the average paternal age of the schizophrenic group was 1.2 years older than the control group. 12 Zammit et al examined children from the Avon Longitudinal Study of Parents and Children (ALSPAC) to determine whether psychosis-like symptoms (PLIKS) during adolescence are associated with a family history of schizophrenia or APA. The researchers found only weak evidence that PLIKS was associated with APA.…”