Association Between Particulate- And Gas-Phase Components of Urban Air Pollution and Daily Mortality in Eight Canadian Cities

Burnett, Richard T.; Brook, Jeffrey R.; Dann, Tom; Delocla, C.; Philips, O.; Cakmak, Sabit; Vincent, Renaud; Goldberg, Mark S.; Krewski, Daniel

doi:10.1080/08958370050164851

Cited by 239 publications

(110 citation statements)

References 23 publications

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“…Although previous epidemiological and ambient studies have found correlations between metals and various measures of health effects (Verma et al, 2010;Pardo et al, 2015;Burnett et al, 2001;Huang et al, 2003;Akhtar et al, 2010;Charrier and Anastasio, 2012), the measured levels of TNF-α, IL-6, and ROS/RNS obtained in this study demonstrate that organic aerosols alone can induce a cellular response. This was previously observed for the oxidative potential as measured by DTT activity as well, where the same laboratory-generated organic aerosol samples catalyzed redox reactions and resulted in measurable DTT decay in the absence of metal species (Tuet et al, 2017).…”

Section: Discussionmentioning

confidence: 72%

Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

et al. 2017

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Abstract. Cardiopulmonary health implications resulting from exposure to secondary organic aerosols (SOA), which comprise a significant fraction of ambient particulate matter (PM), have received increasing interest in recent years. In this study, alveolar macrophages were exposed to SOA generated from the photooxidation of biogenic and anthropogenic precursors (isoprene, α-pinene, β-caryophyllene, pentadecane, m-xylene, and naphthalene) under different formation conditions (RO 2 + HO 2 vs. RO 2 + NO dominant, dry vs. humid). Various cellular responses were measured, including reactive oxygen and nitrogen species (ROS/RNS) production and secreted levels of cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). SOA precursor identity and formation condition affected all measured responses in a hydrocarbon-specific manner. With the exception of naphthalene SOA, cellular responses followed a trend where TNF-α levels reached a plateau with increasing IL-6 levels. ROS/RNS levels were consistent with relative levels of TNF-α and IL-6, due to their respective inflammatory and anti-inflammatory effects. Exposure to naphthalene SOA, whose aromatic-ring-containing products may trigger different cellular pathways, induced higher levels of TNF-α and ROS/RNS than suggested by the trend. Distinct cellular response patterns were identified for hydrocarbons whose photooxidation products shared similar chemical functionalities and structures, which suggests that the chemical structure (carbon chain length and functionalities) of photooxidation products may be important for determining cellular effects. A positive nonlinear correlation was also detected between ROS/RNS levels and previously measured DTT (dithiothreitol) activities for SOA samples. In the context of ambient samples collected during summer and winter in the greater Atlanta area, all laboratory-generated SOA produced similar or higher levels of ROS/RNS and DTT activities. These results suggest that the health effects of SOA are important considerations for understanding the health implications of ambient aerosols.

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Section: Discussionmentioning

confidence: 72%

Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

et al. 2017

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“…The Wndings are consistent with previous observations. Increased hospitalisation and mortality from cardiac and cardiopulmonary disease occur on days of higher PM 2.5 (Burnett et al 2000;Laden et al 2000;Mar et al 2000;Dockery et al 1993;Pope et al 1995;Steib et al 2002;Verrier et al 2002). The incidence of implantable deWbrillator discharges was higher on days of higher air pollution .…”

Section: Discussionmentioning

confidence: 91%

“…Several administrative database studies have reported associations between traYc, another common source of pollution and both cardiac morbidity and mortality (Burnett et al 2000;Laden et al 2000;Mar et al 2000;Peters et al 2004) but the biological mechanism is not well understood. Automobile traYc is a major source of urban air pollution.…”

Section: Introductionmentioning

confidence: 99%

Particulate air pollution and vascular reactivity: the bus stop study

Dales

Liu

Szyszkowicz

et al. 2007

Int Arch Occup Environ Health

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“…Samet et al, 2000). One recent study from Canada has suggested higher mortality risks to be associated with fine PM, rather than with the coarse PM mode (PM 10∼2.5 ) (Burnett et al, 2000). The concentration levels of particulate matter (PM) are considered one of the most potent indicators to diagnose the extent of air pollution (e.g., Lu, 2002;Wilson et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Atmosphic pollutants study of particles ionic species during high wind speed (>7 m s-1) near Taiwan strait in central Taiwan from 2004 to 2005

Fang

Lee

et al. 2006

Environ Monit Assess

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This study monitored atmospheric pollutants during high wind speed (> 7 m s(-1)) at two sampling sites: Taichung Harbor (TH) and Wuci traffic (WT) during March 2004 to January 2005 in central Taiwan. The correlation coefficient (R (2)) between TSP, PM(2.5), PM(2.5-10) particle concentration vs. wind speed at the TH and WT sampling site during high wind speed (< 7 m s(-1)) were also displayed in this study. In addition, the correlation coefficients between TSP, PM(2.5) and PM(2.5-10) of ionic species vs. high wind speed were also observed. The results indicated that the correlation coefficient order was TSP > PM(2.5-10) > PM(2.5) for particle at both sampling sites near Taiwan strait. In addition, the concentration of Cl(-), NO(3) (-), SO(4) (2-), NH(4) (+), Mg(2+), Ca(2+) and Na(+) were also analyzed in this study.

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Association Between Particulate- And Gas-Phase Components of Urban Air Pollution and Daily Mortality in Eight Canadian Cities

Cited by 239 publications

References 23 publications

Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors

Particulate air pollution and vascular reactivity: the bus stop study

Atmosphic pollutants study of particles ionic species during high wind speed (>7 m s-1) near Taiwan strait in central Taiwan from 2004 to 2005

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