Association Between Parkinson Disease and Risk of Cancer in Taiwan

Lin, Pei; Chang, Shih Ni; Hsiao, Tzu Hung; Huang, Bo; Lin, Ching Heng; Yang, Pan‐Chyr

doi:10.1001/jamaoncol.2015.1752

Cited by 70 publications

(95 citation statements)

References 54 publications

(39 reference statements)

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“…A Danish cohort study of 14,088 PD patients [16] and a case-control study of 8,090 Danish PD cases [17] also reported a positive association with ORs of 1.25 and 1.26, respectively. A positive relationship between PD and subsequent NMSCs was also reported in later studies [7, 18, 19], with point estimates ranging between 1.29 and 1.81 [1]. …”

Section: Discussionsupporting

confidence: 69%

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Lerman

Amichai

Weinstein³

et al. 2018

Neuroepidemiology

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Background: The association between Parkinson’s disease (PD) and melanoma is well recognized, but its relationship with non-melanoma skin cancers has not been studied in depth. Objective: To assess the relationship between PD, and risk of melanoma and keratinocyte carcinoma: squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods: This historical cohort study used the data of 1.2 million adult members of a large health organization between 2000 and 2015. Individuals who were diagnosed with PD anytime between 2000 and 2010 were retrospectively followed until 8/2016 for incidence of SCC, BCC, or melanoma identified from physician diagnoses and pathology reports. Results: The PD cohort included 7,727 patients (mean [SD] age = 69.9 [14.8 years]) among the 1,251,695 study population. During follow-up, a total of 4,553, 32,069, and 4,015 cases of BCC, SCC, and melanoma were identified in the study population respectively. Multivariable models revealed that older age, male sex, never smoking, and residence in southern Israel and actinic keratosis were associated with an increased risk of both BCC and SCC. PD patients in the age range 45–64 and 65–84 years at baseline had an OR of 2.11 (95% CI 1.40–3.18) and 1.52 (95% CI 1.21–1.91) for BCC respectively. Weak or no associations were calculated for melanoma or SCC. Conclusions: We report a positive relationship between PD and risk of BCC. These results should stimulate greater awareness on the part of healthcare providers to the increased risk of BCC in PD patients.

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Section: Discussionsupporting

confidence: 69%

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Lerman

Amichai

Weinstein³

et al. 2018

Neuroepidemiology

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“…Although the pathway is a kind of brain disease, it contained many genes related to cell cycle71. Recent cohort study revealed the relationship between parkinson’s disease and cancer72. Also in molecular-level studies, the PARK2 and LRRK2 genes well known in parkinson’s disease were revealed that those genes were related with cell cycle pathways7374.…”

Section: Resultsmentioning

confidence: 99%

Measuring intratumor heterogeneity by network entropy using RNA-seq data

Park

Lim

Nam

et al. 2016

Sci Rep

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Intratumor heterogeneity (ITH) is observed at different stages of tumor progression, metastasis and reouccurence, which can be important for clinical applications. We used RNA-sequencing data from tumor samples, and measured the level of ITH in terms of biological network states. To model complex relationships among genes, we used a protein interaction network to consider gene-gene dependency. ITH was measured by using an entropy-based distance metric between two networks, nJSD, with Jensen-Shannon Divergence (JSD). With nJSD, we defined transcriptome-based ITH (tITH). The effectiveness of tITH was extensively tested for the issues related with ITH using real biological data sets. Human cancer cell line data and single-cell sequencing data were investigated to verify our approach. Then, we analyzed TCGA pan-cancer 6,320 patients. Our result was in agreement with widely used genome-based ITH inference methods, while showed better performance at survival analysis. Analysis of mouse clonal evolution data further confirmed that our transcriptome-based ITH was consistent with genetic heterogeneity at different clonal evolution stages. Additionally, we found that cell cycle related pathways have significant contribution to increasing heterogeneity on the network during clonal evolution. We believe that the proposed transcriptome-based ITH is useful to characterize heterogeneity of a tumor sample at RNA level.

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“…After full article review for the remaining 33 studies, 7 duplicated studies which were performed in the same population and 11 studies which did not meet inclusion criteria were excluded (Supplementary material 1). Finally, 15 studies were included in our meta-analysis [5–7, 11–22] (Figure 1). …”

Section: Resultsmentioning

confidence: 99%

“…In addition, we excluded two studies which were based on Asian population [7, 11] and performed further analyses in Western population. The pooled result showed that patients with PD were significantly associated with a decreased risk of lung cancer in Western population (RR: 0.48, 95% CI: 0.39–0.60, P < 0.001, I 2 = 85%, Table 2).…”

Section: Resultsmentioning

confidence: 99%

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Risk of lung cancer in Parkinson's disease

Xie

Luo

Xie³

et al. 2016

Oncotarget

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Recently, growing evidence has revealed the significant association between Parkinson's disease (PD) and cancer. However, controversy still exists concerning the association between PD and lung cancer. A comprehensive article search for relevant studies published was performed using the following online databases: PubMed, Web of Science and Embase up to August 31, 2016. The pooled risk ratio (RR) and their 95 % confidence intervals (CI) were calculated using the method of inverse variance with the random-effects model. Fifteen studies comprising 348,780 PD patients were included in this study. The pooled result indicated that patients with PD were significantly associated with a decreased risk of lung cancer (RR: 0.53, 95% CI: 0.41−0.70, P < 0.001). In addition, subgroup analyses performed in Western population also confirmed the significant inverse relationship between PD and risk of lung cancer (RR: 0.48, 95% CI: 0.39−0.60, P < 0.001). In the subgroup analysis, a reduced risk of lung cancer in PD patients from Western population was consistent regardless of study design, gender, or study quality. In conclusion, PD patients were significantly associated with a reduced risk of lung cancer in Western population. The relationship between them in Asian population needs to be confirmed by future studies.

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Association Between Parkinson Disease and Risk of Cancer in Taiwan

Cited by 70 publications

References 54 publications

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Parkinson’s Disease, Melanoma, and Keratinocyte Carcinoma: A Population-Based Study

Measuring intratumor heterogeneity by network entropy using RNA-seq data

Risk of lung cancer in Parkinson's disease

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