Association between paraoxonase-1 gene Q192R and L55M polymorphisms and risk of gastric cancer: A case-control study from Iran

Hemati, Mahdie; Mansourabadi, Amir Hossein; Bafghi, Marzie Khebregi

doi:10.1080/15257770.2019.1573371

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Moreover, there were 43 studies with 11412 cases and 13936 controls for PON1-Q192R polymorphism (Table 1), and, for PON1 L55M polymorphism, 28 studies involved a total of 8565 cases and 9996 controls (Table 2). For PON1 Q192R polymorphism, a total of 8 cancer types were processed, including breast cancer [21, 27, 31, 32, 37, 39, 50], prostate cancer [22, 23, 40, 41], gastrointestinal cancer [19, 20, 48, 59, 60], hematologic tumor [25, 29, 33, 44], lung cancer [11, 12, 54], brain tumors [30, 35, 38, 45, 56, 57], ovarian cancer [34, 43] and other cancers [13, 26, 28, 42, 53, 58] (uterine leiomyoma, childhood embryonal tumors, metastatic gastric cancer, bladder cancer, and renal cell cancer). Besides, we disposed a total of 7 cancer types when dealing with PON1-L55M polymorphism nearly like PON1 Q192R polymorphism.…”

Section: Resultsmentioning

confidence: 99%

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Pan

Huang

et al. 2019

BioMed Research International

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Q192R and L55M polymorphism were considered to be associated with the development of multiple cancers. Nevertheless, the results of these researches were inconclusive and controversial. Therefore, we conducted a meta-analysis of all eligible case-control studies to assess the association between PON1 (Q192R and L55M) gene polymorphisms and risk of cancer. With the STATA 14.0 software, we evaluated the strength of the association by using the odds ratios (ORs) and 95% confidence intervals (CIs). A total of 43 case-control publications 19887 cases and 23842 controls were employed in our study. In all genetic models, a significant association between PON1-L55M polymorphisms and overall cancer risk was observed. Moreover, in the stratified analyses by cancer type, polymorphism of PON1-L55M played a risk factor in the occurrence of breast cancer, hematologic cancer, and prostate cancer. Similarly, an increased risk was observed in the Caucasian and Asian population as well as hospital-based group and population-based group. For PON1-Q192R polymorphisms, in the stratified analyses by cancer type, PON1-Q192R allele was associated with reduced cancer risks in breast cancer. Furthermore, for racial stratification, there was a reduced risk of cancer in recession model in Caucasian population. Similarly, in the stratification analysis of control source, the overall risk of cancer was reduced in the heterozygote comparison and dominant model in the population-based group. In conclusion, PON1-Q192R allele decreased the cancer risk especially breast cancer; there was an association between PON1-L55M allele and increased overall cancer risk. However, we need a larger sample size, well-designed in future and at protein levels to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Pan

Huang

et al. 2019

BioMed Research International

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“…The human body, including the gut, skin, and other mucosal environments, is colonized by a massive number of microorganisms, collectively named the microbiome [1]. Novel progress in microbiome research revealed that DOI: 10.1159/000525695 the gut microbiome is not just a passive bystander but actively affects several host functions, including nutritional responses, metabolism, immunity, and cancer immunotherapy [2].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer

Azimi

Shahbaz

Mansourabadi

et al. 2022

Int Arch Allergy Immunol

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The human colon harbors a diverse array of microorganisms that play fundamental roles in colorectal cancer (CRC). Increasing evidence indicates that dysbiosis of the intestinal microbiome has been associated with the development of CRC. Interaction between host genetics, intestinal microbiota, and lifestyle is well-indicated in the influence, prevention, and treatment of CRC. Various microbiome compositions have reported anticancer and/or anti-inflammatory properties. The presence of our microbiota is integral to our development, but a change in its composition can often lead to adverse effects, increasing the propensity for serious diseases like cancers. Recently, molecular detection and metabolomic techniques have increased our knowledge of the role of microbiota in promoting tumorigenesis. Dietary interventions may be appropriate to regulate the growth of beneficial microbiota in the gut. Metagenomic approaches along with immunology and metabolomics will obvious a new path for the treatment of CRC. In this study, we summarized recent advances in understanding the mechanisms involved in microbiota-related colorectal carcinoma, based on evidence from immunotherapy studies.

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Vitamin E intake and paraoxonase 1 (PON1) rs662 genetic polymorphism are associated with colorectal cancer risk in a Korean population

Bui

Gunathilake

Lee

et al. 2023

International Journal of Food Sciences and Nutrition

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Association between paraoxonase-1 gene Q192R and L55M polymorphisms and risk of gastric cancer: A case-control study from Iran

Cited by 4 publications

References 39 publications

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies

Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer

Vitamin E intake and paraoxonase 1 (PON1) rs662 genetic polymorphism are associated with colorectal cancer risk in a Korean population

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