Association between panic disorder, major depressive disorder and celiac disease

Carta, Mauro Giovanni; Hardoy, Maria Carolina; Boi, Maria Francesca; Mariotti, Stefano; Carpiniello, Bernardo; Usai, Paolo

doi:10.1016/s0022-3999(02)00328-8

Cited by 122 publications

(112 citation statements)

References 25 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…Adjustment to the diagnosis and the GFD could, however, plausibly differ according to both age of diagnosis and duration of GFD, suggesting that these variables may also moderate the adherencedepression relationship. CD patients with comorbid IBS-type symptoms (Hauser, Musial, Caspary, Stein, & Stallmach, 2007), diabetes and autoimmune conditions (Garud et al, 2009), and elevated thyroid anti-bodies (Carta et al, 2002), have higher rates of depression than patients with CD alone, suggesting that controlling for the presence of comorbidities may also help to explain differences in effects. Representativeness and recruitment or selection bias are common problems in CD research, and it is possible that differences in motivation and dietary vigilance exist according to membership of a coeliac society (Hall et al, 2009), which may change the results if more diverse recruitment methods were used.…”

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Sainsbury

Marques

2018

Appetite

View full text Add to dashboard Cite

Conflicts of interest: none Funding: none 2The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis ABSTRACT Purpose: Depressive symptoms are common in patients with coeliac disease (CD) and may represent a barrier to gluten free diet (GFD) adherence. The aims of this meta-analysis were: (1) to synthesise the evidence on the relationship between depression or depressive symptoms and degree of adherence to a GFD in patients with CD who are already attempting a GFD (i.e., post-diagnosis and onset of GFD), and (2) to summarise the direction of causation of any observed relationship. Methods:A random effects meta-analysis of 8 cross-sectional studies (N=1644) was conducted.Included studies measured self-reported depressive symptoms and GFD adherence using either a dietitian interview or validated self-report questionnaire that considered unintentional gluten consumption.Results: There was a moderate association between poorer GFD adherence and greater depressive symptoms (r=0.398, 95% CI=0.321-0.469), with marked heterogeneity in the effects (I 2 =66.8%). A sensitivity analysis excluding studies with a moderate/high (k=1) or unclear risk of bias (k=1) did not change the results. Conclusion:The low number of studies meeting inclusion criteria limits the strength of the conclusions. Available evidence suggests there is an association between poorer GFD adherence and self-reported depressive symptoms; however, studies using longitudinal and prospective designs, and reliable measures, particularly for adherence, are needed to confirm this association. The direction of causation between depression and adherence remains unclear.

show abstract

Section: Limitations and Directions For Future Researchmentioning

confidence: 99%

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Sainsbury

Marques

2018

Appetite

View full text Add to dashboard Cite

show abstract

“…21 Independently of GFD, psychological morbidities in CD may also be secondary to CD associated with autoimmune diseases. For example, Carta et al in 2002 67 showed that the association of CD with thyroid disease can represent a significant risk factor for depression and panic disorders. Some years later, Garud Associated autoimmune diseases 67,68 et al 68 described a similar risk of depression in CD when compared with the general population but a markedly elevated risk of depression in patients both with CD and type I diabetes.…”

Section: Mechanisms Explaining Psychological Morbiditiesmentioning

confidence: 99%

“…For example, Carta et al in 2002 67 showed that the association of CD with thyroid disease can represent a significant risk factor for depression and panic disorders. Some years later, Garud Associated autoimmune diseases 67,68 et al 68 described a similar risk of depression in CD when compared with the general population but a markedly elevated risk of depression in patients both with CD and type I diabetes. A possible explanation of this increased risk may be that the cytokines produced by immune reactions may exercise an effect on the brain circuits responsible for mood regulation.…”

Section: Mechanisms Explaining Psychological Morbiditiesmentioning

confidence: 99%

Psychological morbidity of celiac disease: A review of the literature

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Carta et al [73] found a significantly higher number of CD patients met the criteria for lifetime and 6-month major depressive disorder and panic disorder compared to controls. Other studies have reported higher rates of social phobia [74], anxiety [75,76], depression [74,77,78], and dysthymia [45].…”

Section: Depression and Anxietymentioning

confidence: 99%

Neuropsychiatric Features of Celiac Disease

Arnone

Conti²

2016

IJCD

View full text Add to dashboard Cite

Celiac disease (CD) is a T-cell mediated genetically inherited autoimmune disease that has evolved over time. Formerly considered a pediatric disease, the rate of occurrence is now observed in individuals ranging from early childhood to senescence. Strict adherence to a gluten-free diet is the only currently available treatment for CD in order for individuals to avert future complications and malignancies. In the United States, the disease has shown widespread incidence and prevalence rates and affects 1% of the total population in not-at-risk groups. This number translates into 1 out of 133 people in the United States affected, making the disease almost 100 times more common than previously considered. While histological, genetic, incidence and prevalence of disease and quality of life research studies are replete in the extant literature, up until recently, neurological and psychological manifestations have also been studied among this cohort in relation to CD. Neurological conditions such as ataxia and neuropathy in CD have received the most research attention while much less attention has been paid to psychiatric conditions and cognitive functioning. The findings on cognitive functioning in CD have revolved largely around anecdotal reports and small clinical trials totaling approximately 200 patients of varying ages. Studies reporting neuropsychological test data are few and often do not include comprehensive test batteries in which to draw further conclusions on specific cognitive deficits. Larger, well-controlled studies are needed in order to form optimal diagnosis and implementation of specific support measures for individuals living with CD across the lifespan.

show abstract

Association between panic disorder, major depressive disorder and celiac disease

Cited by 122 publications

References 25 publications

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

Psychological morbidity of celiac disease: A review of the literature

Neuropsychiatric Features of Celiac Disease

Contact Info

Product

Resources

About