Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Longini, Mariangela; Perrone, Serafina; Vezzosi, Piero; Marzocchi, Barbara; Kenanidis, A.; Centini, Giovanni; Rosignoli, L.; Buonocore, Giuseppe

doi:10.1016/j.clinbiochem.2007.03.004

Cited by 122 publications

(65 citation statements)

References 32 publications

(44 reference statements)

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“…Rosen et al (2001) Candidate biomarkers of impending preterm PROM increased concentrations of plasma thrombin-antithrombin complexes in the maternal blood correlate with subsequent preterm PROM. Another study conducted by Longini et al (2007) found isoprostane (a by-product of lipid peroxidation) to be significantly higher in the amniotic fluid collected at 15-18 weeks' gestation from women who deliver preterm following subsequent preterm PROM compared with women with normal term labour. In this current study, we investigated alterations in the CVF protein expression of asymptomatic women, without clinical signs of infection, who progressed to preterm PROM and subsequently delivered preterm.…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes

et al. 2013

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A significant obstetric complication facing contemporary materno-fetal medicine is preterm premature rupture of the fetal membranes (preterm PROM), which occurs in 30% of all preterm births. The objective of this study was to identify differentially expressed proteins in the cervicovaginal fluid of asymptomatic women before the clinical manifestation of preterm PROM. The preterm PROM group comprised of women with samples collected 6-23 days before PROM, who subsequently delivered preterm (nZ5). Women who spontaneously delivered at term served as gestation-matched controls (nZ10). Two-dimensional difference in-gel electrophoresis was used to distinguish differential expression between the pooled groups and fold changes were subsequently confirmed by two-dimensional PAGE of individual samples. Spots of interest were identified by mass spectrometry. Proteins that were significantly reduced with impending preterm PROM included the following: thioredoxin (2.7-fold), interleukin 1 receptor antagonist (1.7-fold), fatty acid-binding protein 5 (2.1-fold), cystatin A (dimer; 1.9-fold), monocyte/neutrophil elastase inhibitor (1.6-fold), squamous cell carcinoma antigen-1 (2.1-fold) and g-glutamyl cyclotransferase (3.0-fold). By contrast, annexin A3 (3.7-fold) and vitamin D binding protein (3.9-fold) were significantly increased with impending preterm PROM. Western blot analysis was also performed on an independent cohort of preterm PROM and control samples to validate these candidate biomarkers. These proteins have known biological functions in oxidative balance, anti-inflammatory activity, metabolism or protease inhibition that may facilitate membrane rupture.

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Section: Discussionmentioning

confidence: 99%

Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes

et al. 2013

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“…Plasma IP levels are significantly higher in neonates than in older infants and are inversely correlated with GA [10]. We previously found that measurement of IP levels in cord blood is a reliable marker for early identification of intrauterine OS conditions such as preterm premature rupture of membrane or fetal growth restriction or the infant born small for gestational age [11,12]. We hypothesized that antioxidant therapy is suitable for reducing OS.…”

Section: Introductionmentioning

confidence: 95%

Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure

et al. 2010

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Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU). PDA is strictly related to oxidative stress (OS) in neonates. This study tests the hypothesis that OS occurs in neonates with PDA and that IBU treatment reduces OS. Forty-three preterm babies with gestational age (GA) <33 weeks were studied prospectively. Three urine samples were collected: at time 0 (before starting treatment), time 1 (after pharmacological PDA closure), and time 2 (7 days after the end of treatment) in all patients. OS was studied by measuring urinary isoprostane (IPs) levels. The results showed significant changes in urinary IP levels from time 0 to time 2 (Kruskal-Wallis, p=0.047). Time trend showed a significant decrease in IPs from time 0 to time 1 after IBU therapy (p=0.0067). This decrease was followed by an increase in IPs levels 7 days after treatment. IBU therapy for PDA closure reduced the risk of OS related to free-radical (FR) generation. This antioxidant effect of IBU may be beneficial in preterm babies with PDA who are at high risk for OS.

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“…The formation of ROS is subsequently increased, which may potentially entail adverse effects inducing any kind of free radical-related disease [34,35,36,37,38]. Studies in which samples of cord blood or venous blood of newborns were investigated have shown that children are born with a low antioxidative status [33].…”

Section: Discussionmentioning

confidence: 99%

“…Some perinatological diseases of mother and child are associated with excessive radical formation. Preeclampsia [34], premature rupture of the membranes [35], necrotising enterocolitis [36], retinopathy of prematurity [37] and periventricular leukomalacia [38] are only a few examples of free radical-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Spectroscopic Determination of the Antioxidative Status of Gravidae and Neonates

Lademann

Gerber²,

Olbertz³

et al. 2015

Skin Pharmacol Physiol

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Pregnancy and postpartum adaptation cause an increased formation of free radicals. This is associated with various perinatological diseases, e.g. necrotising enterocolitis. The human body has developed a protective system in the form of the antioxidative potential. The present study was the first to investigate the kinetics of the cutaneous antioxidative status in pregnant women and newborns using a non-invasive spectroscopic method. Eighteen pregnant women and their babies took part in the study. A light-emitting diode-based compact scanner system was used for quick non-invasive measurements of carotenoid antioxidants in human skin based on reflection spectroscopy. It could be shown that the antioxidative status of the expectant mothers significantly declined during labour (p < 0.001) and on day 1 after delivery (p < 0.01). Compared to the mothers, the newborns exhibited a significantly higher cutaneous carotenoid concentration on both day 1 (p < 0.01) and 5 (p < 0.01) after delivery. These results suggest that the oxidative stress due to postpartum adaptation is counteracted by an enhanced reservoir of carotenoid antioxidants in the subcutaneous fatty tissue. The peripartum cutaneous carotenoid level of mothers declines continuously, whereas term newborns show very high cutaneous antioxidant values.

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Association between oxidative stress in pregnancy and preterm premature rupture of membranes

Cited by 122 publications

References 32 publications

Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes

Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes

Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure

Non-Invasive Spectroscopic Determination of the Antioxidative Status of Gravidae and Neonates

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