Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study

Sun, Ming‐Hui; Liao, Yaping Joyce; Lin, Chia-Hung; Chiang, Rayleigh Ping-Ying; Wei, James Cheng‐Chung

doi:10.1038/s41433-018-0088-1

Cited by 12 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A sleep study later on revealed an undiagnosed severe OSA. This case is an example to support the idea of recent literature that OSA is a strong risk factor for NAION 2 3 5 12–14…”

Section: Discussionsupporting

confidence: 78%

“…Numerous studies have suggested the association between NAION and OSA by evaluating the prevalence of OSA in NAION patients and vice versa 2 3 5 12–14. The prevalence of OSA in NAION patients was reported to be 71% (12 of 17 cases) by Mojon et al 2 and 89% (24 of 27 cases) by Palombi et al 3.…”

Section: Discussionmentioning

confidence: 99%

“…The results suggested that OSA not treated with CPAP posed a 16% increase in the risk of developing NAION. Most recently, a large longitudinal health insurance database study among Asian population showed that OSA patients had a 1.95-fold higher risk of NAION compared with controls in all age groups and that the risk was significantly higher (adjusted HR: 4.21) in patient less than 45 years old and male individuals (adjusted HR: 1.93) 12. Many of these studies were included in a systematic review and meta-analysis, which concluded that there was robust evidence that OSA was a strong independent risk factor for NAION with more than a sixfold increase in risk 14…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man

Lei

Micieli

2019

BMJ Case Rep

View full text Add to dashboard Cite

Non-arteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in older individuals but may also occur in younger patients. A 30-year-old man presented with a 2-day history of right eye painless vision loss and was found to have right optic disc oedema and a left ‘disc-at-risk’. He was diagnosed with right NAION and review of symptoms revealed witnessed apnea at night and episodes where he woke up gasping for air, concerning for obstructive sleep apnea (OSA). A formal sleep study revealed severe OSA and he was treated with continuous positive airway pressure to reduce his risk of fellow eye involvement and reduce his overall cardiovascular risk. OSA should be considered in every patient with NAION, especially in younger patients without any additional risk factors.

show abstract

“…A sleep study later on revealed an undiagnosed severe OSA. This case is an example to support the idea of recent literature that OSA is a strong risk factor for NAION 2 3 5 12–14…”

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man

Lei

Micieli

2019

BMJ Case Rep

View full text Add to dashboard Cite

show abstract

“…First, the common theory is that inherent vibration injury to soft tissue over oropharynx leads to peripheral neuropathy or hypoxia both [17][18][19]. Second, surgery induces avor disorder [33]. Due to high availability and low cost, one population-based study using NHIRD from 2002-2010 showed that 17.9% (922/5139) of patients accept surgery for OSA including oropharyngeal surgery and nasal surgery [32].…”

Section: Discussionmentioning

confidence: 99%

Flavor Disorder Is Associated with Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study

Tsao

Huang

Hung

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Flavor sensation was the joint perception of smell and taste sensation was associated with the pleasure of life. Obstructive sleep apnea (OSA) had been demonstrated the presence of upper airway remodeling which altered sensory and motor function due to hypoxia or snore vibration. This study aims to investigate whether OSA is associated with the risk of flavor disorder (FD). Methods: We conducted a nationwide cohort study using the Taiwan National Health Insurance Research Database, one million subjects were sampled with data collected from 1999 to 2013 and 9,191 identified diagnosed OSA patients were included. Each patient was matched with non-OSA controls from the general population by propensity score matching (1:1) based on age, gender, hypertension, hyperlipidemia, ankylosing spondylitis, and Charlson comorbidity index, 8,037 OSA and an equal number of non-OSA subjects were used to compared in this study. The incidence of FD was assessed at the end of 2013 and cumulative incidences, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Results: The adjusted HR (aHR)of FD for the OSA group was 2.082-fold (95% CI = 1.149–3.773, p=0.0155) higher than non-OSA group. The stratified analyses revealed aHR of FD for the hyperlipidemia group was 2.264-fold (95% CI = 1.061–4.832, p=0.035). Subgroup analysis showed the subjected of female OSA had more risk to develop FD (aHR:2.345, 95% CI = 1.026–5.357, p=0.043). Conclusion: A higher risk of developing FD was found among the newly diagnosed OSA cohort during the longer than 10-year follow-up period

show abstract

“…Obstructive sleep apnea (OSA) is characterized by recurrent complete or partial upper airway occlusion during sleep that causes a decrease in airflow as well as oxygen desaturation [1,2]. OSA has been associated with several ophthalmic conditions, such as floppy eyelid syndrome [3,4], central serous choroidoretinopathy [5][6][7][8], retinal vein occlusions [9], papilledema [10,11], nonarteritic anterior ischemic optic neuropathy [11][12][13][14][15][16][17], and is currently widely accepted as a risk factor for glaucoma [1,2,18]. The association between glaucoma and OSA has been reported in various studies, most of which were case-control or cross-sectional studies on the prevalence of these conditions or correlation of OSA severity with structural and functional changes related to glaucomatous damage [19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Correlation between structural progression in glaucoma and obstructive sleep apnea

Fan

Liu

et al. 2019

Eye

Self Cite

View full text Add to dashboard Cite

Background/objectives To investigate the correlation between obstructive sleep apnea (OSA) severity and the structural and functional progression in patients with glaucoma. Subjects/methods This retrospective comparative cohort study included subjects from the polysomnography database in Chang Gung Memorial Hospital between June 1, 2009, and June 1, 2017, by identifying patients who had received diagnoses of primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), or glaucoma suspect. Patients with follow-up time of <3 years and/or <3 consecutive reliable optical coherence tomography (OCT) or visual field (VF) tests were excluded. Progression of overall peripapillary retinal nerve fiber layer (RNFL) thickness on OCT scans and VF mean deviation (MD) or VF index (VFI) were determined through linear regression trend analysis. Results Thirty-two patients were included. There was a trend to higher percentage of progression on RNFL thickness and VF in higher OSAS severity. After stratifying patients to no OSA/mild OSA (group 1) and moderate/severe OSA (group 2), group 2 exhibited a significantly higher percentage of RNFL thickness progression than did group 1 (64.7% vs 26.7%, P = 0.042). Multivariate Cox regression analysis showed that severe OSA had an 8.448-fold higher risk of RNFL thickness progression after age, sex, diabetes mellitus, hypertension, hyperlipidemia, and body mass index adjustment (95% confidence interval, 1.464-48.752, P = 0.017). Conclusions Severe OSA is significantly correlated with a higher risk of structural deterioration in patients with glaucoma.

show abstract

Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study

Cited by 12 publications

References 23 publications

Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man

Severe obstructive sleep apnea diagnosed after non-arteritic anterior ischaemic optic neuropathy in a young man

Flavor Disorder Is Associated with Obstructive Sleep Apnea: A Nationwide Population-Based Cohort Study

Correlation between structural progression in glaucoma and obstructive sleep apnea

Contact Info

Product

Resources

About