Association between obesity and risk of chronic kidney disease: A nationwide Cohort study in Taiwan

Lai, Yun‐Ju; Hu, Hsiao Yun; Lee, Y. L.; Ku, Po-Wen; Yen, Yung‐Feng; Chu, Dominic

doi:10.1016/j.numecd.2017.08.006

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…The relation between obesity and kidney disease is thought to be associated with increased renal mass, glomerular and tubular hypertrophy, haemodynamic changes, increased salt sensitivity, activation of the renin‐angiotensin‐aldosterone system and adipose tissue‐related inflammation. The proteinuria and fibrosis that result from these structural and functional changes in obese patients lead to the progression of kidney disease . Adipose tissues contain a range of different stromal cells, such as fibroblasts, endothelial cells and immune cells.…”

Section: Discussionmentioning

confidence: 99%

“…The proteinuria and fibrosis that result from these structural and functional changes in obese patients lead to the progression of kidney disease. [22][23][24] Adipose tissues contain a range of different stromal cells, such as fibroblasts, endothelial cells and immune cells. Although the involvement of fibroblasts in adipose homeostasis is still unclear, fibroblasts are known to exhibit various functions in tissue morphogenesis, wound healing, fibrosis and cancer by regulating the behaviour and functions of epithelial cells and stem cells.…”

Section: Discussionmentioning

confidence: 99%

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Elevated serum levels of procollagen C‐proteinase enhancer‐1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate

et al. 2019

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Background Procollagen C‐proteinase enhancer‐1 (PCPE‐1) is a 55 kDa glycoprotein, which increases the activity of procollagen C‐proteinases that break down C‐terminal propeptides. Studies have shown that PCPE‐1 is involved in the fibrotic process that occurs in various tissues and organs. Our review of the literature revealed no data concerning the relation between PCPE‐1 and chronic kidney disease (CKD). The purpose of this study was to determine PCPE‐1 levels in CKD. Methods One hundred thirty‐one CKD patients and 34 healthy controls were included in our study. Demographic data were recorded, and routine biochemical tests were performed. Blood specimens were collected for PCPE‐1 investigation. Demographic data, biochemical test results and PCPE‐1 levels were compared between the control and patient groups. Parameters affecting PCPE‐1 levels in our patient group were assessed. Results Procollagen C‐proteinase enhancer‐1 levels were significantly higher in our patient group compared to the control group. Parameters affecting PCPE‐1 elevation in the patient group were identified as systolic blood pressure, blood urea nitrogen, phosphorus, haemoglobin, intact parathormone levels, glomerular filtration rate and body mass index. Conclusion We determined high PCPE‐1 levels in CKD patients. PCPE‐1 levels being negatively correlated with glomerular filtration rate suggests that PCPE‐1 may be associated with progression in CKD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Elevated serum levels of procollagen C‐proteinase enhancer‐1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate

et al. 2019

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“…Previous studies had reported the relationship between obesity with renal function by using different anthropometric parameters. The risk of developing incident CKD was higher in the obese defined by body mass index (BMI) than normal weight subjects 4 . In a previous study, waist-to-hip ratio (WHR) had more close association with the incident CKD and mortality rather than BMI 5 .…”

Section: Introductionmentioning

confidence: 99%

Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function

Chen

Fang

Wang

et al. 2018

Sci Rep

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The association between anthropometric indices with chronic kidney disease (CKD) was examined previously. However, the effect of body fat on renal function was not determined clearly. Our aim was to investigate the association of percent body fat (PBF) and renal function in adult population from health examination in Tri-Service General Hospital (2010–2016). 35087 participants aged 20 years and older were enrolled in the study. PBF was measured by bioelectrical impedance analysis (BIA). Estimation of renal function was performed by Taiwanese MDRD equation. Optimal cut-off values of PBF was accessed by a receiver–operator characteristic (ROC) curve analysis. Multivariate regression models were used in the relationship among changes of PBF, renal function, and future CKD. In terms of baseline PBF for CKD, optimal cut-off values of PBF in males and females were 21.55 and 40.75. The changes of PBF were more closely associated with renal function decline than waist circumference (WC) with β values of −0.173 (95% CI: −0.233, −0.112) and −0.077 (95% CI: −0.104, −0.049), respectively. After stratified by gender, this relationship remained significant in male population with β values of −0.276 (95% CI: −0.371, −0.181) and −0.159 (95% CI: −0.207, −0.112), respectively. Female subjects with increased baseline PBF over cut-off values had increased risk for predicting the future CKD with odd ratios (ORs) of 2.298 (95% CI: 1.006–5.252). Body fat had detrimental impact on renal function and development of CKD in adult population. Measurement of PBF for surveillance of renal function impairment was warranted.

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“…Furthermore, snoring resulted in increased ORs of CKD independent of hyperglycemia (Table ; model 6). Accumulating evidence has shown that obesity is an independent risk factor of CKD, as well as for the progression from CKD to kidney failure and the need for dialysis. Positive associations between snoring and abdominal obesity and BMI have been observed.…”

Section: Discussionmentioning

confidence: 99%

Self‐reported snoring is associated with chronic kidney disease independent of metabolic syndrome in middle‐aged and elderly Chinese

Song

Wang

et al. 2018

J of Diabetes Invest

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Association between obesity and risk of chronic kidney disease: A nationwide Cohort study in Taiwan

Cited by 18 publications

References 32 publications

Elevated serum levels of procollagen C‐proteinase enhancer‐1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate

Elevated serum levels of procollagen C‐proteinase enhancer‐1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate

Changes of Percent Body Fat as a Useful Surrogate for Risk of Declined Renal Function

Self‐reported snoring is associated with chronic kidney disease independent of metabolic syndrome in middle‐aged and elderly Chinese

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