Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val158Met polymorphism

Demetrovics, Zsolt; Varga, Gábor; Székely, Anna; Vereczkei, Andrea; Csorba, Jozsef; Balázs, Hedvig; Hoffman, Katalin; Sasvári-Székely, Mária; Barta, Csaba

doi:10.1016/j.comppsych.2009.11.008

Cited by 34 publications

(32 citation statements)

References 39 publications

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“…In support of previous research, Met 158 homozygous allele carriers show higher novelty seeking scores compared to Val 158 allele carriers [12,13,22]. However this has not been shown in ultra-endurance athletes.…”

Section: Discussionsupporting

confidence: 83%

“…Met 158 homozygous allele carriers with greater phasic dopamine neurotransmission [1] would be expected to score higher on novelty seeking (NS). This has been well-supported in the literature among different populations including: Russian women [22]; bipolar patients [12]; methylphenidate dependent patients [27]; and heroin dependent patients [13]. However, it is not known whether a similar relationship between novelty seeking and the COMT polymorphism exists in an ultra-endurance population.…”

Section: Introductionmentioning

confidence: 92%

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The COMT val158met polymorphism in ultra-endurance athletes

Breda

Collins

Stein

et al. 2015

Physiology & Behavior

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 92%

The COMT val158met polymorphism in ultra-endurance athletes

Breda

Collins

Stein

et al. 2015

Physiology & Behavior

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“…Traits such as harm avoidance (HA) in TCI, neuroticism in NEO, and BIS all belong to negative emotionality (NEM), whereas novelty seeking (NS) in TCI, extraversion in NEO, and BAS belong to positive emotionality (PEM; Reuter et al, 2006b). Associations between COMT Val/Met and PEM/NEM were quite mixed, with nine studies showing no significant associations (Strobel et al, 2003;Tochigi et al, 2006;Ishii et al, 2007;Light et al, 2007;Urata et al, 2007;Sheldrick et al, 2008;Calati et al, 2011;Kang et al, 2010;Salo et al, 2010), seven studies showing the Val allele associated with high PEM or low NEM (Enoch et al, 2003;Tsai et al, 2004;Reuter and Hennig, 2005;Stein et al, 2005;Hoth et al, 2006;Hashimoto et al, 2007;Wacker and Gatt, 2010), and three studies showing the opposite (Met allele associated with high PEM or low NEM; Kim et al, 2006;Golimbet et al, 2007;Demetrovics et al, 2010), and three studies reported opposite pattern for males and females (Eley et al, 2003;Reuter et al, 2006b;Lang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Sex Modulates the Associations Between the COMT Gene and Personality Traits

Chen

Moyzis

Dong

et al. 2011

Neuropsychopharmacol

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Previous research has shown inconsistent findings regarding the relations between the functional Val158Met polymorphisms of the catechol-O-methyltransferase (COMT) gene and individual differences in personality traits. This study attempts to overcome some of the weaknesses of previous research, namely, small sample sizes, clinical samples, ethnic stratification, wide age ranges, neglecting sex differences, and single measures of personality traits. A large sample (n ¼ 556, 250 male, 306 female) of healthy Chinese college students (mean age ¼ 20.5 ± 1 years) was given a battery of personality scales, including the temperament and character inventory-revised, the behavioral inhibition system and behavioral approach system scale, the Beck depression inventory, and the Beck anxiety inventory. Factor analysis of the affect-related personality traits revealed two factors that corresponded to positive (PEM) and negative emotionality (NEM). We found a consistent COMT-by-sex interaction effect on affect-related personality traits. Compared with males with Met/Met alleles, males with Val/Val alleles showed significantly higher scores on NEM, but lower scores on PEM. Females, however, showed an opposite but nonsignificant pattern. Our results supported the role of the COMT gene in personality traits for males and contributed to the growing literature on sex differences in gene-behavior connections.

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“…Strong evidence emerged from existing studies that the polymorphisms in DRD4, DRD2 and 5-HTTLPR were not connected to novelty-seeking personality (Burt, McGue, Iacono, Comings, & MacMurray, 2002;de Brettes et al, 1998;Ebstein, 2006;Ebstein et al, 1997;Hill, Zezza, Wipprecht, Locke, & Neiswanger, 1999;Kluger, Siegfried, & Ebstein, 2002;Kreek, Nielsen, Butelman, & LaForge, 2005; S. H. Lee, Ham, Cho, Lee, & Shim, 2007;Light et al, 2007;Munafò et al, 2003;Ricketts et al, 1998;Samochowiec et al, 2001;Schinka, Letsch, & Crawford, 2002;Suzuki et al, 2008;Tsuchimine et al, 2012;Van Gestel et al, 2002). In contrast, studies on COMT polymorphism revealed mixed and conflicting results (Calati et al, 2011;Demetrovics et al, 2010;Golimbet, Alfimova, Gritsenko, & Ebstein, 2007;Hashimoto et al, 2007;Hosák, Libiger, Cizek, Beránek, & Cermáková, 2006;Hoth et al, 2006;Kim, Kim, Kim, Lee, & Kim, 2006;Lichtenberg, Bachner-Melman, Ebstein, & Crawford, 2004;Light et al, 2007;Reuter & Hennig, 2005; S.-J. Tsai, Hong, Yu, & Chen, 2004).…”

Section: Novelty-seekingmentioning

confidence: 99%

Genetic-linked Inattentiveness Protects Individuals from Internet Overuse: A Genetic Study of Internet Overuse Evaluating Hypotheses Based on Addiction, Inattention, Novelty-seeking and Harm-avoidance

et al. 2016

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The all-pervasive Internet has created serious problems, such as Internet overuse, which has triggered considerable debate over its relationship with addiction. To further explore its genetic susceptibilities and alternative explanations for Internet overuse, we proposed and evaluated four hypotheses, each based on existing knowledge of the biological bases of addiction, inattention, novelty-seeking, and harm-avoidance. Four genetic loci including DRD4 VNTR, DRD2 Taq1A, COMT Val158Met and 5-HTTLPR length polymorphisms were screened from seventy-three individuals. Our results showed that the DRD4 4R/4R individuals scored significantly higher than the 2R or 7R carriers in Internet Addiction Test (IAT). The 5-HTTLPR short/short males scored significantly higher in IAT than the long variant carriers. Bayesian analysis showed the most compatible hypothesis with the observed genetic results was based on attention (69.8%), whereas hypotheses based harm-avoidance (21.6%), novelty-seeking (7.8%) and addiction (0.9%) received little support. Our study suggests that carriers of alleles (DRD4 2R and 7R, 5-HTTLPR long) associated with inattentiveness are more likely to experience disrupted patterns and reduced durations of Internet use, protecting them from Internet overuse. Furthermore, our study suggests that Internet overuse should be categorized differently from addiction due to the lack of shared genetic contributions.

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Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val158Met polymorphism

Cited by 34 publications

References 39 publications

The COMT val158met polymorphism in ultra-endurance athletes

The COMT val158met polymorphism in ultra-endurance athletes

Sex Modulates the Associations Between the COMT Gene and Personality Traits

Genetic-linked Inattentiveness Protects Individuals from Internet Overuse: A Genetic Study of Internet Overuse Evaluating Hypotheses Based on Addiction, Inattention, Novelty-seeking and Harm-avoidance

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