The COMT val158met polymorphism in ultra-endurance athletes

Breda, Keelyn Van; Collins, Malcolm; Stein, Dan J.; Rauch, Laurie

doi:10.1016/j.physbeh.2015.07.039

Cited by 12 publications

(9 citation statements)

References 49 publications

(55 reference statements)

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“…The positive relationship between resilience and stress seems to be clear in the qualitative literature [3, 7–9], while the quantitative literature presents direct inverse correlations to stress and stress correlates [10–13], resulting in lower levels of anxiety and higher levels of self-concept, self-esteem, psychological well-being and adaptive coping strategies [14–18]. In this sense, psychological resilience could be a protective factor for injury due to its relationship to stress; however, no studies have investigated the relationship between resilience, stress and injury in elite athletes.…”

Section: Introductionmentioning

confidence: 99%

Resilience, stress and injuries in the context of the Brazilian elite rhythmic gymnastics

et al. 2018

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The study had the goal to study the relationship between resilience, stress and injuries in the sport context. Eight female athletes, part of the Rhythmic Gymnastics Brazilian Team along the Olympic Cycle 2015–2016 participated in the study, with a mean age of 20.4±2.5 years. The following instruments were used: RESTQ-76 Sport, CD-RISC 10, documental analysis of physical therapy records, and structured questionnaire. Data was analyzed by descriptive statistics (frequency, mean and standard deviation); Repeated Measured ANOVA with Bonferroni’s post-hoc, Student’s “t” test, Friedman test, Pearson Correlation Coefficient, Cohen’s d, and inductive thematic analysis. We found relatively stable levels of stress and recovery across the season; total recovery levels were higher than stress at all four measured timepoints (p<0.05); All athletes had at least one injury, with a total of 14 injuries; No significant correlations were found between the quantitative scores of resilience, stress and recovery; Training and the sport’s scoring system were the most relevant perceived stressors; athletes presented meta-cognition and a non-positive evaluation (neutral) of stressors; Social support was considered the main psychological factor for the resilience process; such process resulted in improved control and interpretation of emotions; Our hypothesized model proposes that, in the relationship between stress and injuries, resilience acts by optimizing the injury recovery process. It was concluded that resilience plays a role in the process of injury rehabilitation and stress control in elite rhythmic gymnastics’ athletes.

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Section: Introductionmentioning

confidence: 99%

Resilience, stress and injuries in the context of the Brazilian elite rhythmic gymnastics

et al. 2018

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“…These effects may be advantageous or disadvantageous depending on the phenotype, as well as numerous endogenous and environmental factors [20]. In the other study, the authors suggested that the chronic levels of physical activity, as seen in ultra-endurance athletes, show increased novelty-seeking in Met (158) homozygous allele carriers supporting the hypothesis that there is an association between personality traits and COMT Val158Met (rs4680) genotype [23]. The association between genetic variation and temperamental traits has been also confirmed in a study conducted by Leznicka and co-workers, in which associations between a functional polymorphism of the COMT gene and FCB-TI scores for temperament traits were found [24].…”

Section: Discussionmentioning

confidence: 87%

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Żmijewski

Leońska-Duniec

Stuła

et al. 2021

Genes

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Swimmers’ competitive performance is a result of complicated interactions between physiological, biochemical, physical and psychological factors, all of which are strongly affected by water. Recently, great attention has been paid to the role of genetic factors such as the catechol-O-methyltransferase gene (COMT) influencing motivation, emotions, stress tolerance, self-control, sleep regulation, pain processing and perception, addictive behaviour and neurodegeneration, which may underlie differences in achieving remarkable results in sports competition. Thus, this study was performed to investigate the association between the COMT Val158Met (rs4680) polymorphism and athletic performance in Caucasian swimmers. A total of 225 swimmers (171 short distance (SDS) and 54 long distance swimmers (LDS)) of national or international competitive standard and 379 unrelated sedentary controls were genotyped using real-time polymerase chain reaction (real-time PCR). We found no significant differences in genotypic or allelic distributions between (1) male and female athletes; (2) SDS and LDS; (3) all athletes and sedentary controls (under codominant, dominant, recessive, and overdominant genetic models). No association was found between the COMT rs4680 polymorphism and elite swimming athlete status of the studied population. However, more replication studies are needed.

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“…Whilst traditional research has focused on the physiological drivers of elite athlete status (reviewed in detail by Ahmetov and colleagues [16]), there is the potential to explore the genetic underpinnings of psychological factors, such as anxiety, stress resilience, and skill acquisition. This has not yet been explored in detail, although a SNP in catechol-O-methyltransferase (COMT) gene, rs4680, has been linked with competition performance in swimmers [66] and with personality traits in ultra-endurance athletes [67]. Catechol-o-methyltransferase plays a role in the regulation of dopamine within the prefrontal cortex [19]; variation in this SNP affects dopamine levels and thus information processing and memory [19].…”

Section: What Could We Potentially Use Genetic Testing For?mentioning

confidence: 99%

Can Genetic Testing Identify Talent for Sport?

Pickering

Kiely

Grgić

et al. 2019

Genes

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Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is considerable interest in attempting to utilise genetic information as a tool to predict future elite athlete status. In this review, we explore the extent of the genetic influence on the making of a sporting champion and we describe issues which, at present, hamper the utility of genetic testing in identifying future elite performers. We build on this by exploring what further knowledge is required to enhance this process, including a reflection on the potential learnings from the use of genetics as a disease prediction tool. Finally, we discuss ways in which genetic information may hold utility within elite sport in the future, including guiding nutritional and training recommendations, and assisting in the prevention of injury. Whilst genetic testing has the potential to assist in the identification of future talented performers, genetic tests should be combined with other tools to obtain an accurate identification of those athletes predisposed to succeed in sport. The use of total genotype scores, composed of a high number of performance-enhancing polymorphisms, will likely be one of the best strategies in the utilisation of genetic information to identify talent in sport.

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The COMT val158met polymorphism in ultra-endurance athletes

Cited by 12 publications

References 49 publications

Resilience, stress and injuries in the context of the Brazilian elite rhythmic gymnastics

Resilience, stress and injuries in the context of the Brazilian elite rhythmic gymnastics

Evaluation of the Association of COMT Rs4680 Polymorphism with Swimmers’ Competitive Performance

Can Genetic Testing Identify Talent for Sport?

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