Association between non-alcoholic fatty pancreatic disease (nafpd) and the metabolic syndrome: case–control retrospective study

Abstract

BackgroundFatty liver is associated with insulin resistance, dyslipidemia, and obesity and is therefore considered a phenotype of metabolic syndrome. However, less is known regarding the metabolic abnormalities associated with non-alcoholic fatty pancreatic disease (NAFPD; fatty pancreas). The present study was performed to ascertain whether fatty pancreas is associated with specific metabolic risk factors and with metabolic syndrome as defined by the Adult Treatment Panel III.MethodsFive-hundred-fifty-seven healthy and consecutive subjects without known hypertension or diabetes and who received a health investigation at the National Taiwan University Hospital Health Management Center were enrolled in this retrospective study. Fatty pancreas was diagnosed via trans-abdominal ultrasonographic findings.ResultsSeventy-two (12.9%) subjects diagnosed with fatty pancreas comprised the fatty pancreas group, and remaining subjects comprised the normal pancreas group. The presence of various demographic and metabolic risk factors was recorded for all subjects, and the two groups were examined for statistically significant differences in these factors. As compared to the absence of fatty pancreas, the presence of the disease was associated with older age and with higher values for each of the following: BMI, abdominal girth/height, abdominal girth (both genders), fasting and postprandial blood glucose, HbA1c, total cholesterol, triglycerides, LDL-cholesterol, systolic blood pressure, and platelet count. In contrast to previously reported findings, serum amylase values were lower in the fatty pancreas as compared to the control group.ConclusionThe presence of fatty pancreas represents a meaningful manifestation of metabolic syndrome together with obesity.

Non-alcoholic fatty pancreas disease

“…In 2013, Wu and Wang et al 23 confirmed an association between the occurrence of fatty pancreas and metabolic risk factors. Results suggested that older age, greater BMI, increased abdominal waist circumference and metabolic variables (glycated haemoglobin, lipid parameters and systolic blood pressure) were associated with NAFPD 23…”

“…The central factor bringing these conditions together is the metabolic syndrome, diagnosis of which is based on the National Cholesterol Education Program Adult Treatment Panel III when three or more of the following criteria are present: abdominal obesity (waist circumference ≥90 cm for males or ≥80 cm for females), increased triglyceride concentration (≥150 mg/dL), decreased high-density lipoprotein cholesterol (HDL-C) (<40 mg/dL for males or <50 mg/dL for females), hypertension (systolic blood pressure ≥130 mm Hg and diastolic blood pressure ≥85 mm Hg) and elevated fasting blood glucose concentration (≥110 mg/dL) 23. Therefore, it should go without saying that every patient with metabolic syndrome should undergo evaluation for both NAFLD and NAFPD.…”

Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature

“…Obesity also leads to the infiltration of fat in organs such as heart, kidneys, liver and pancreas [10]. Wu et al found that fatty pancreas is strongly associated with specific parameters of metabolic syndrome such as obesity, increased fasting blood glucose, elevated HbA1c and dyslipidemia [33]. It can be implied that NAFPD may represent a meaningful manifestation of metabolic syndrome.…”

Image Evaluation and Association Analysis of the Cardiovascular Disease of the Degree of Pancreatic Steatosis in Ultrasonography

“…A previous study has reported the strong association between fatty liver disease and metabolic relevance is high previous study [4]. Non-alcoholic fatty liver was also shown to predict the occurrence of cardiovascular disease, such as dyslipidemia, abdominal obesity, and metabolic syndrome [5]. An increase of fat deposition in pancreas as well as liver appeared as an HE abnormality in several clinical index values.…”