Association between non-alcoholic fatty liver disease and colorectal cancer

Parizadeh, Seyed Mostafa; Alizade-Noghani, Mohadese; Ghandehari, Maryam; Mottaghi-Moghaddam, Ali; Goldani, Fatemeh; Khazaei, Majid; Hassanian, Seyed Mahdi

doi:10.1080/17474124.2019.1617696

Cited by 20 publications

(16 citation statements)

References 49 publications

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“…NAFLD can range from simple steatosis, which typically has a benign presentation, to non-alcoholic steatohepatitis (NASH), which can progress to cirrhosis or hepatocellular carcinoma. Moreover, compelling evidence suggests that NAFLD is closely associated with numerous chronic diseases, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD) and colorectal cancer ( 2 – 4 ). However, to date there is no effective drug for treatment of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

et al. 2022

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BackgroundSarcopenia is known to be the risk factor of non-alcoholic fatty liver disease (NAFLD). However, studies evaluating the association of skeletal muscle mass (SMM) with liver fibrosis by transient elastography are limited. Here, we investigated the association of SMM with hepatic steatosis and fibrosis assessed in Chinese adults.MethodsPatients who underwent liver ultrasonography at the Health Promotion Center of the First Affiliated Hospital of Nanjing Medical University between January 2020 to June 2021 were enrolled. We used transient elastography to evaluate the degree of hepatic fat and liver stiffness. Appendicular skeletal muscle mass was determined by bioelectrical impedance and was adjusted for body weight to derive the skeletal muscle mass index (SMI).ResultsOf 3,602 finally enrolled individuals, 1,830 had NAFLD and 1,772 did not have NAFLD. SMI gradually decreased as the severity of hepatic steatosis increased (40.47 ± 3.94% vs. 39.89 ± 3.57% vs. 39.22 ± 3.46% vs. 37.81 ± 2.84%, P < 0.001). Individuals with F3-F4 and F2 liver fibrosis groups had significantly lower SMI than individuals with F0-F1 stages (37.51 ± 3.19% vs. 38.06 ± 3.51% vs. 39.36 ± 3.38%, P < 0.001). As the SMI increased, the percentages of subjects with mild and severe NAFLD, and the percentages of subjects in F2 and F3-F4 stage were gradually decreased. SMI was independently associated with the severity of hepatic steatosis and fibrosis by logistic regression analysis. Moreover, decreased SMI was an independent risk factor for NAFLD and fibrosis.ConclusionSMI is closely associated with liver fat content and liver fibrosis in Chinese adults with NAFLD.

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Section: Introductionmentioning

confidence: 99%

Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

et al. 2022

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“…[ 17 ] found that the liver density was lower in CRC patients than in those without CRC on contrast-enhanced CT. Our study showed that the liver density was lower in patients who had more adenomatous polyps than in those with a normal liver density, as measured by unenhanced CT. Most CRC develops through the adenoma-carcinoma sequence[ 18 ]. As the liver fat content was easily accessible, we suggest that NAFLD patients with high liver fat content undergo colonoscopy in a timely manner to detect high-risk colorectal polyps.…”

Section: Discussionmentioning

confidence: 99%

Correlation of liver-to-spleen ratio on computed tomography with colorectal polyps

Zhou¹,

Yang²,

Wan³

et al. 2021

ceh

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Aim of the study:To explore the correlation of the liver-to-spleen (L/S) ratio on computed tomography (CT) with colorectal polyps. Material and methods: Consecutive participants from Jinling Hospital Affiliated to Nanjing University who underwent routine biochemical tests, colonoscopies, and CT between January 2018 and December 2019 were selected. The L/S ratio on CT was used to measure the liver fat content. Colonoscopy findings were applied to create the polyp-free group and colorectal polyp group. All included subjects were also classified in the non-alcoholic fatty liver disease (NAFLD) group or the non-NAFLD group according to the CT (L/S) ratio to identify risk factors for colorectal polyps. All data were analysed with SPSS 25 software. Results: Among 481 participants, 27.8% (79/284) of the patients were diagnosed with NAFLD in the colorectal group, which was higher than the corresponding proportion of the polyp-free group [9.1% (18/197)]. In NAFLD patients, most adenomatous polyps were found in the transverse colon, and hyperplastic polyps were largely located in the rectum. Linear regression suggested that the CT (L/S) ratio correlated with the number of colorectal polyps and with the number of adenomatous polyps. After adjusting for confounding factors, multivariate analysis indicated that NAFLD was an independent risk factor for adenomatous polyps and hyperplastic polyps. Conclusions: A lower CT (L/S) ratio (higher liver fat content) was significantly correlated with a higher risk of colorectal polyps. This finding suggested that NAFLD patients with a reduced CT (L/S) ratio need to undergo colonoscopy examinations to detect high-risk colorectal polyps in a timely manner.

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“…Its incidence has increased in recent decades, and now more than one million Colorectal cancer patients are diagnosed and thousands succumb to the disease annually (7). The 5-year survival rate varies according to the stage at diagnosis, which is approximately 90% in the early stages of disease, and <10% in advanced disease (8). Colorectal polyps, particularly adenomatous polyps (including serrated adenomas), have been shown to be associated with the development of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Patients with non‑alcoholic fatty liver disease may be a high‑risk group for the development of colorectal polyps: A cross‑sectional study

Xie

Zhou

et al. 2020

World Acad Sci J

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Non-alcoholic fatty liver disease (NAFLD) and colorectal polyps have been shown to have similar pathogenic factors. The understanding of the association between these two pathologies may contribute to the early diagnosis and treatment of colorectal tumors. The present study compared the biological characteristics of colorectal polyps between patients with and without NAFLD. For this purpose, 1,538 patients with colorectal polyps treated from July, 2013 and June, 2020 were included and divided into the NAFLD and control group (non-NAFLD group). The location, number, morphology, size and pathology of the polyps were compared between the 2 groups. For the analysis of the biological characteristics of the polyps, the multiple of number (74.5%), percentages of polyps >1.0 cm in diameter (62%) and polyps with advanced adenomas. For the analysis of the biological characteristics of the polyps, the multiple of number (74.5%), percentages of polyps in diameter of 1.0 to <2.0 cm + ≥2.0 cm (48.4 and 13.6%, respectively) and polyps with advanced adenomas (62.9%) in the NAFLD group exhibited significant differences compared with the control group (69.5, 39.2, 6.3 and 55.3%, respectively; all P<0.05); however, no significant differences were observed in the location and morphology of the colorectal polyps between the patients with NAFLD and the controls (P>0.05). When the patients were stratified by sex, age and body mass index, it was found that the patients in the NAFLD group with a polyp size <1.0 cm and those with advanced adenomas exhibited significant differences compared with the control group (P<0.05, respectively). Further analysis revealed that the classification percentage of advanced adenomas in the NAFLD group only exhibited a statistically significant difference compared with the control group in patients with a lower weight (P<0.05). On the whole, the present study demonstrates that NAFLD is significantly associated with the presence of colorectal polyps, particularly in patients with multiple polyps, those with a large size and with villous features (advanced adenomas). Patients with NAFLD may thus be considered a target group for screening colonoscopy.

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Association between non-alcoholic fatty liver disease and colorectal cancer

Cited by 20 publications

References 49 publications

Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

Correlation of liver-to-spleen ratio on computed tomography with colorectal polyps

Patients with non‑alcoholic fatty liver disease may be a high‑risk group for the development of colorectal polyps: A cross‑sectional study

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