Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

Guo, Wen; Xin, Zhao; Miao, Mengyuan; Liang, Xiuru; Li, Xiaona; Qin, Pei; Lü, Jing; Zhu, Wen; Wu, Juan; Chen, Zhu; Xu, Nianzhen; Zhang, Qun

doi:10.3389/fnut.2022.883015

Cited by 12 publications

(8 citation statements)

References 35 publications

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“…Similar to our findings, a cross-sectional analysis of 3589 participants from China reported that there was an independent positive association of the android fat ratio and an inverse association of the skeletal muscle index (SMI) with NAFLD defined by the fatty liver index 13. Another study from China conducted by Guo et al , using transient elastography to assess the degree of liver steatosis and stiffness, found that SMI was independently associated with the severity of liver steatosis and fibrosis 14. Shida et al found that NAFLD patients in Japan with a reduced ratio of skeletal muscle mass to visceral fat area had an increased risk of moderate to severe steatosis and advanced fibrosis 12.…”

Section: Discussionsupporting

confidence: 89%

“…Several studies have reported that the ratio of skeletal muscle mass to visceral fat area is closely related to the pathophysiology of NAFLD in Korea11 and Japan 12. Previous studies in China have reported the association of android fat and/or skeletal muscle with NAFLD 13 14. However, it remains unclear whether the fat-to-muscle ratio (FMR), a novel assessment of the combined effects of fat and skeletal muscle mass, is associated with the risk of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

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Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study

Yan,

Nie,

Zhou

et al. 2023

BMJ Open

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ObjectivesSarcopenia is a known risk factor for non-alcoholic fatty liver disease (NAFLD). Studies evaluating the association between the fat-to-muscle ratio (FMR) and NAFLD are limited. Therefore, the aim of our study was to investigate the association between FMR and NAFLD.DesignA retrospective study was conducted on individuals who underwent health examination at Wuhan Union Hospital between January 2020 and November 2021. Clinical data were collected from electronic medical records.SettingWuhan Union Hospital, Wuhan, China.Participants1592 participants aged ≥40 years who underwent body composition analysis and liver ultrasonography were retrospectively reviewed.Outcome measuresLiver ultrasonography was used to assess liver steatosis, and the fibrosis-4 index was used to calculate the risk scores for liver fibrosis. The 10-year atherosclerotic cardiovascular disease (ASCVD) risk prediction model was used to calculate ASCVD risk scores.ResultsThe FMR was significantly higher in individuals with NAFLD than in those without NAFLD (p<0.001). The prevalence of NAFLD gradually increased from FMR tertile 1 (reference) to tertile 2 (OR=1.49, 95% CI 1.13 to 1.97) and tertile 3 (OR=2.85, 95% CI 2.08 to 3.90). In addition, patients with NAFLD in FMR tertile 3 had a significantly higher risk of liver fibrosis (OR=4.48, 95% CI 2.12 to 9.50) and ASCVD (OR=4.63, 95% CI 2.62 to 8.19) than those in FMR tertile 1 after adjustment for multiple confounders.ConclusionIn this study, we found a significant association between FMR and NAFLD. A higher FMR indicates a higher risk of NAFLD in the study population and a higher risk of liver fibrosis and ASCVD in NAFLD patients.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study

Yan,

Nie,

Zhou

et al. 2023

BMJ Open

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“…The close link between body composition parameters and NAFLD has been investigated. Previous studies have shown that obesity 27 , 28 , visceral adiposity 29 , 30 , and sarcopenia 13 , 31 , are associated with an increased risk for NAFLD. Obesity seems to play a role in both the initial process of simple hepatic steatosis and its progression to advanced liver disease 32 .…”

Section: Discussionmentioning

confidence: 98%

Effects of additive interactions among obesity, visceral adiposity, and sarcopenia on nonalcoholic fatty liver disease

Chung

Ahn

et al. 2023

Sci Rep

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Although the association of nonalcoholic fatty liver disease (NAFLD) with obesity or sarcopenia is known, few studies have investigated the combined effect of various body composition parameters on the risk of NAFLD. Thus, the aim of this study was to evaluate effects of interactions between various body composition parameters, including obesity, visceral adiposity, and sarcopenia, on NAFLD. Data of subjects who underwent health checkups between 2010 and December 2020 were retrospectively analyzed. Body composition parameters including appendicular skeletal muscle mass (ASM) and visceral adiposity were assessed using bioelectrical impedance analysis. Sarcopenia was defined as ASM/weight beyond two standard deviations below the gender-specific mean for healthy young adults. NAFLD was diagnosed using hepatic ultrasonography. Interaction analyses, including relative excess risk due to interaction (RERI), synergy index (SI), and attributable proportion due to interaction (AP), were performed. Among a total of 17,540 subjects (mean age: 46.7 years, 49.4% males), the prevalence of NAFLD was 35.9%. The odds ratio (OR) of interaction between obesity and visceral adiposity affecting NAFLD was 9.14 (95% CI: 8.29–10.07). The RERI was 2.63 (95% CI: 1.71–3.55), SI was 1.48 (95% CI: 1.29–1.69) and AP was 29%. The OR of interaction between obesity and sarcopenia affecting NAFLD was 8.46 (95% CI: 7.01–10.21). The RERI was 2.21 (95% CI: 0.51–3.90). SI was 1.42(95% CI: 1.11–1.82) and AP was 26%. The OR of interaction between sarcopenia and visceral adiposity affecting NAFLD was 7.25 (95% CI: 6.04–8.71), however, there was no significant additive interaction with RERI = 0.87 (95% CI: −0.76 to 2.51). Obesity, visceral adiposity, and sarcopenia were found to be positively associated with NAFLD. Obesity, visceral adiposity, and sarcopenia were found to have additive interaction effects on NAFLD.

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“…The sample is not representative for the study population, which may limit the generalizability of the results. Many variables which may influence the presence of NAFLD were not taken into consideration for this study, such as skeletal muscle mass and comorbidities related to metabolic syndrome including diabetes mellitus, hypertension, and dyslipidemia [ 11 , 19 , 51 ]. So, results must be interpreted cautiously as many confounding variables were not analyzed.…”

Section: Discussionmentioning

confidence: 99%

Waist Circumference as a Risk Factor for Non-Alcoholic Fatty Liver Disease in Older Adults in Guayaquil, Ecuador

et al. 2023

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Non-alcoholic liver steatosis is currently considered an epidemic. It involves a broad spectrum of liver diseases, in which older adults constitute a susceptible group. The aim of this study is to identify the role of waist circumference as a risk factor for non-alcoholic fatty liver disease. Methods: A cross-sectional study was carried out in 99 older adults who regularly attended five gerontological centers in the city of Guayaquil, Ecuador. The variables studied were age, gender, independent life, access to complete meals, waist circumference, and NAFLD diagnosed by ultrasound. Results: A significant relationship exists between waist circumference, body mass index, and fat mass percentage. However, only age and waist circumference were significant in the multivariate logistic regression model. Our results suggest that in the presence of waist circumference, body mass index loses its significance and age may be a protective factor due to adipose tissue loss and redistribution. Conclusion: Anthropometric measurements such as waist circumference can be used as complement indicators of NAFLD.

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Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease

Cited by 12 publications

References 35 publications

Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study

Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study

Effects of additive interactions among obesity, visceral adiposity, and sarcopenia on nonalcoholic fatty liver disease

Waist Circumference as a Risk Factor for Non-Alcoholic Fatty Liver Disease in Older Adults in Guayaquil, Ecuador

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