Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study

Feng, Xingliang; Mei, Yifang; Wang, Xiaogang; Cui, Li; Xu, Ran

doi:10.3389/fendo.2023.1192113

Cited by 3 publications

(2 citation statements)

References 53 publications

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“… 27 , 28 Another study also showed that MHR can be used as an independent predictor of response to phosphodiesterase 5 inhibitor therapy for ED. 47 However, these studies on MHR and ED had small sample sizes and insufficient evidence, so this study used nationally representative data from NHANES to build on the available evidence.…”

Section: Discussionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Wu,

Zhang,

Jiang

et al. 2024

Sexual Medicine

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Background The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has become a novel inflammation marker with a possible association with erectile dysfunction (ED); however, there are fewer studies exploring the association between MHR and ED. Aim This study sought to explore the association between MHR and ED. Methods This study population was drawn from participants in two 2-year cycles of the National Health and Nutrition Examination Survey (2001-2002 and 2003-2004). MHR was calculated as the ratio of monocyte count (103 cells/μL) to high-density lipoprotein cholesterol (mg/dL). The relationship between MHR and ED was explored using survey-weighted logistic regression models with MHR as a continuous variable and divided into tertiles (tertile 1 [T1]: <0.01; T2: 0.01-0.014; T3: >0.014). We also used a smooth curve fit (penalized spline method) to characterize the dose-response relationship between MHR and ED. In addition, subgroup analyses based on age, body mass index, smoking, hypertension, diabetes mellitus, and cardiovascular disease were performed to further analyze the data. Sensitivity analyses were also conducted to further assess the stability of the results. Outcomes The main outcome measure was the difference in ED prevalence between MHR levels. Results A total of 1361 participants were enrolled, with 513 (T1), 438 (T2), and 410 (T3) participants in the 3 MHR groups. After adjusting for all potential covariates, survey-weighted logistic regression analyses showed a significant association between MHR and ED (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.26-3.05). When MHR was used as a categorical variable, the adjusted OR for ED prevalence increased significantly with increasing MHR after adjusting for all potential covariates (T3 vs T1: OR, 2.14; 95% CI, 1.29-3.55). The dose-response curves showed that the prevalence of ED increased with increasing MHR. Clinical Implications Easy to access and low cost, MHR is a convenient clinical tool that helps clinicians in the prevention and treatment of ED. Strengths and Limitations The present study is the first to examine the association between MHR and ED nationally representative data. However, the study population was derived from a U.S. database, so the findings are limited to the U.S. population. Conclusion Our study demonstrated that MHR levels were independently associated with ED and that ED patients had higher MHR levels, suggesting that MHR may be a valuable predictor for identifying people at higher risk for ED.

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Section: Discussionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Wu,

Zhang,

Jiang

et al. 2024

Sexual Medicine

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“…Using the Coulter counter method, we obtained the neutrophil count (NC) and lymphocyte count (LC) from the whole blood. The ratio of NC to LC was then used to calculate the NLR ( 19 ). We also looked at the associations between DKD and other inflammatory markers, such as the platelet-to-lymphocyte ratio (PLR) (PLR= platelet count(PC)/LC), monocyte-to-lymphocyte ratio (MLR) (MLR= monocyte count(MC)/LC), systemic immune-inflammation index (SII) (SII=PC * NC/LC), system inflammation response index (SIRI) (SIRI=NC * MC/LC), and aggregate index of systemic inflammation (AISI) (AISI=NC * PC * MC/LC), to fully assess the relationship between NLR and DKD.…”

Section: Methodsmentioning

confidence: 99%

Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Li,

Wang,

Liu

et al. 2024

Front. Endocrinol.

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AimsThis investigation examined the possibility of a relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients.MethodsAdults with T2DM who were included in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2020 were the subjects of the current cross-sectional investigation. Low estimated glomerular filtration rate (eGFR) (< 60 mL/min/1.73 m2) or albuminuria (urinary albumin-to-creatinine ratio (ACR) ≥ 30 mg/g) in T2DM patients were the diagnostic criteria for DKD. Weighted multivariable logistic regression models and generalized additive models were used to investigate the independent relationships between NLR levels with DKD, albuminuria, and low-eGFR. Additionally, we examined the relationships between DKD, albuminuria, and low-eGFR with other inflammatory markers, such as the aggregate index of systemic inflammation (AISI), systemic immune-inflammation index (SII), system inflammation response index (SIRI), and platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR). Their diagnostic capabilities were evaluated and contrasted using receiver operating characteristic (ROC) curves.Results44.65% of the 7,153 participants who were recruited for this study were males. DKD, albuminuria, and low-eGFR were prevalent in 31.76%, 23.08%, and 14.55% of cases, respectively. Positive correlations were seen between the NLR with the prevalences of DKD, albuminuria, and low-eGFR. Subgroup analysis and interaction tests revealed that the associations of NLR with DKD, albuminuria, and low-eGFR were not significantly different across populations. In addition, MLR, SII and SIRI showed positive associations with the prevalence of DKD. ROC analysis discovered that when compared to other inflammatory markers (MLR, PLR, SII, SIRI, and AISI), NLR may demonstrate more discriminatory power and accuracy in assessing the risk of DKD, albuminuria, and low-eGFR.ConclusionCompared to other inflammatory markers (MLR, PLR, SII, SIRI, and AISI), NLR may serve as the more effective potential inflammatory marker for identifying the risk of DKD, albuminuria, and low-eGFR in US T2DM patients. T2DM patients with elevated levels of NLR, MLR, SII, and SIRI should be closely monitored for their potential risk to renal function.

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Novel predictive factor for erectile dysfunction: systemic immune inflammation index

Gao,

Wu,

Zhang

et al. 2024

Int J Impot Res

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Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study

Cited by 3 publications

References 53 publications

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Novel predictive factor for erectile dysfunction: systemic immune inflammation index

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