Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Li, Xiaowan; Wang, Lanyu; Liu, Min; Zhou, Hongyi; Xu, Hongyang

doi:10.3389/fendo.2023.1285509

Cited by 7 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above studies suggest that the SIRI is closely related to cardiovascular and cerebrovascular diseases. Two recent retrospective analyses of diabetic patients suggest that the SIRI is an independent risk factor for deteriorating kidney function [ 30 , 31 ]. In earlier studies, increased neutrophil and monocyte counts as well as decreased lymphocyte counts were associated with decreased kidney function.…”

Section: Discussionmentioning

confidence: 99%

Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients

Wei,

Feng

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

Background Chronic kidney disease (decreased kidney function) is common in hypertensive patients. The SIRI is a novel immune biomarker. We investigated the correlation between the SIRI and kidney function in hypertensive patients. Methods The present study analyzed data from participants who suffered from hypertension in the NHANES from 2009 to 2018. Multivariate regression analysis and subgroup analysis were used to clarify whether the SIRI was an independent risk factor for decreased kidney function. RCSs were utilized to evaluate the correlation between the SIRI and the eGFR and between the SIRI and the ACR. In addition, we modeled the mediating effect of the SIRI on the eGFR and the ACR using blood pressure as a mediating variable. Results The highest SIRI was an independent risk factor for a decreased eGFR [odds ratio (OR) = 1.46, 95% CI (1.15, 1.86)] and an increased ACR [OR = 2.26, 95% CI (1.82, 2.82)] when the lowest quartile was used as the reference. The RCS results indicated an inverted U-shaped relationship between the SIRI and the eGFR and between the SIRI and the ACR (the inflection points were 1.86 and 3.09, respectively). The mediation effect analysis revealed that the SIRI was the main factor influencing kidney function, and diastolic blood pressure was a mediating variable. In particular, there was a fully mediating effect between the SIRI and UCr, with a mediating effect value of -0.61 (-0.90, -0.36). Conclusions The association between the SIRI and renal function in hypertensive patients was significant and was particularly dominated by the association between the SIRI and the ACR. This difference may be due to the mediating effect of diastolic blood pressure.

show abstract

Section: Discussionmentioning

confidence: 99%

Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients

Wei,

Feng

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

show abstract

“…Li et al suggested that NLR might be an effective potential inflammatory marker for identifying the risk of diabetic kidney disease in T2DM patients in the United States. T2DM patients with elevated NLR levels should have their potential risk to kidney function closely monitored [ 47 ]. Studies have also found that NLR is highly valuable in diagnosing diabetic retinopathy [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study

Chen,

Wu,

Cao

et al. 2024

BMC Endocr Disord

View full text Add to dashboard Cite

Background Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease often accompanied by low-grade inflammation. Recently, the neutrophil-to-lymphocyte ratio (NLR) has garnered researchers’ interest as an emerging inflammation biomarker. This study aimed to comprehensively explore the relationship between NLR and T2DM using the National Health and Nutrition Examination Survey (NHANES) database. Method We employed a cross-sectional study design to analyze data from five NHANES cycles from 2007 to 2016, excluding individuals with incomplete data. This study utilized a weighted logistic regression model, subgroup analyses, and restricted cubic spline (RCS) analysis to assess the potential relationship between NLR and T2DM. Results A total of 9903 participants were eligible for the analysis, of which 1280 were diagnosed with T2DM. The T2DM group exhibited significantly higher NLR levels than the non-T2DM group. After adjusting for potential confounders, elevated NLR levels were associated with an increased risk of developing T2DM, indicated by an odds ratio (OR) of 1.14, 95% CI: (1.05,1.24), P = 0.003. The results of the subgroup analyses revealed a significant interaction effect between NLR and T2DM concerning race and hypertension (P for interaction < 0.05). In contrast, no significant interactions were found for age, sex, education level, body mass index (BMI), smoking status, recreational activities, and alcohol drinker (P for interaction > 0.05). RCS analysis showed a significant non-linear relationship between NLR and T2DM, with an inflection point at 2.27 (all P for non-linearity < 0.05). Conclusion Our study indicates that an elevated neutrophil-to-lymphocyte ratio is associated with a higher risk of T2DM.

show abstract

“…These confounders included age, race, sex, marital status, family income to poverty ratio (PIR), and educational level, among other demographic factors. We also included a number of laboratory and anthropometric factors, including CVD, alcohol consumption, smoking status, total cholesterol (TC), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood uric acid, serum phosphorus, and body mass index (BMI) ( 7 , 15 – 17 ).…”

Section: Methodsmentioning

confidence: 99%

Association between systemic inflammation response index and chronic kidney disease: a population-based study

Li,

Cui,

2024

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

IntroductionOur objective was to explore the potential link between systemic inflammation response index (SIRI) and chronic kidney disease (CKD).MethodsThe data used in this study came from the National Health and Nutrition Examination Survey (NHANES), which gathers data between 1999 and 2020. CKD was diagnosed based on the low estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 or albuminuria (urinary albumin-to-creatinine ratio (ACR) of more than 30 mg/g). Using generalized additive models and weighted multivariable logistic regression, the independent relationships between SIRI and other inflammatory biomarkers (systemic immune-inflammation index (SII), monocyte/high-density lipoprotein ratio (MHR), neutrophil/high-density lipoprotein ratio (NHR), platelet/high-density lipoprotein ratio (PHR), and lymphocyte/high-density lipoprotein ratio (LHR)) with CKD, albuminuria, and low-eGFR were examined.ResultsAmong the recruited 41,089 participants, males accounted for 49.77% of the total. Low-eGFR, albuminuria, and CKD were prevalent in 8.30%, 12.16%, and 17.68% of people, respectively. SIRI and CKD were shown to be positively correlated in the study (OR = 1.24; 95% CI: 1.19, 1.30). Furthermore, a nonlinear correlation was discovered between SIRI and CKD. SIRI and CKD are both positively correlated on the two sides of the breakpoint (SIRI = 2.04). Moreover, increased SIRI levels were associated with greater prevalences of low-eGFR and albuminuria (albuminuria: OR = 1.27; 95% CI: 1.21, 1.32; low-eGFR: OR = 1.11; 95% CI: 1.05, 1.18). ROC analysis demonstrated that, compared to other inflammatory indices (SII, NHR, LHR, MHR, and PHR), SIRI exhibited superior discriminative ability and accuracy in predicting CKD, albuminuria, and low-eGFR.DiscussionWhen predicting CKD, albuminuria, and low-eGFR, SIRI may show up as a superior inflammatory biomarker when compared to other inflammatory biomarkers (SII, NHR, LHR, MHR, and PHR). American adults with elevated levels of SIRI, SII, NHR, MHR, and PHR should be attentive to the potential risks to their kidney health.

show abstract

Association between neutrophil-to-lymphocyte ratio and diabetic kidney disease in type 2 diabetes mellitus patients: a cross-sectional study

Cited by 7 publications

References 41 publications

Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients

Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients

The association between the neutrophil-to-lymphocyte ratio and type 2 diabetes mellitus: a cross-sectional study

Association between systemic inflammation response index and chronic kidney disease: a population-based study

Contact Info

Product

Resources

About