Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction

Smith, Patrick J.; Blumenthal, James A.; Babyak, Michael A.; Georgiades, Anastasia; Sherwood, Andrew; Sketch, Michael H.; Watkins, Lana L.

doi:10.3945/ajcn.2008.26829

Cited by 29 publications

(17 citation statements)

References 57 publications

(53 reference statements)

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“…Indeed, the Physician's Health Study reported a 52% reduction in the risk of sudden death in subjects who ingested fish at least once per week but no reduction in the risk for myocardial infarction (Albert et al, 1998. The incidence of ventricular arrhythmias was inversely related to dietary n−3 PUFAs; an effect that remained even after other cardiovascular comorbidities were controlled (Smith et al, 2009). An even more striking association between n−3 PUFA consumption and reduced risk for sudden death has been reported in studies in which blood n−3 PUFA levels were determined (Siscovick et al, 1995;Albert et al, 2002;Pottala et al, 2010;Aarsetoey et al, 2011); the subjects with the highest n−3 PUFA blood levels exhibited a 70% to 90% reduction in the risk for sudden cardiac death .…”

Section: Epidemiological Studiesmentioning

confidence: 96%

The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment

Billman

2013

Pharmacology & Therapeutics

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Section: Epidemiological Studiesmentioning

confidence: 96%

The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment

Billman

2013

Pharmacology & Therapeutics

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“…And if such a mechanism of omega-3 fatty acids exists, perhaps an earlier intervention when life-threatening arrhythmias ensue would be best. Despite evidence that links n-3 fatty acid consumption before hospitalization to a reduced risk of ventricular arrhythmias among AMI patients, 18 evidence to document a benefit of omega-3 supplementation within the first several days after an infarct is lacking.…”

Section: Article See P 2152mentioning

confidence: 99%

The Fish Oil Story Remains Fishy

Eckel

2010

Circulation

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“…Further evidence indicate that total fat, saturated fat and trans fat can enhance inflammation and visceral obesity resulting in to MS and treatment with w-3 fatty acids may be beneficial [40][41][42]. In a recent study, a total of 117 volunteers completed the 12-week trial.…”

Section: Risk Factorsmentioning

confidence: 99%

Association of Higher Omega-6/Omega-3 Fatty Acids in the Diet with Higher Prevalence of Metabolic Syndrome in North India

Singh¹

2017

MOJPH

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Background: The epidemic of obesity and hypertension over the last two decades, in the middle and high income countries is associated with marked rise in the incidence of metabolic syndrome Objective: To measure the prevalence of metabolic syndrome (MS) and determine its association with ratio of omega-6/omega-3 fatty acids in the diet. Design and Methods:Cross-sectional surveys were conducted in 20 urban streets in the city of Moradabad, India. Randomly selected subjects with MS aged 25 years and above were evaluated and graded according to omega-6/omega-3 ratio in the diet. Physical examination, sphygmomanometer, questionnaire and blood tests were done. Results:The overall prevalence of MS was 19.3% (n=387) and hypertension 26.6% (n=533) without any gender difference. The prevalence of MS, type 2 diabetes, CAD and hypertension showed a trend of higher rate, in relation to omega-6/omega-3 ratio in the diet. Subgroup analysis showed that subjects eating low omega-6/ omega-3 ratio (<5.0) diets had significantly lower prevalence of MS, and related components compared to higher ratio diets, among both sexes. Multivariate logistic regression analysis after adjustment of age showed, that hypertriglyceridemia (odds ratio 0.90 in men, 0.76 in women) was strongly (P<0.01) associated with MS. Hypertension, HDL-C, and central obesity were weakly associated with MS in both sexes. Hypercholesterolemia was weakly associated with MS only in women. Conclusion:MS has become a public health problem in India. Higher w-6/w-3 ratio is a major risk factor of MS and CAD. It is possible that a low w-6/w-3 ratio in the diet (<5.0) may be protective against MS and related components.

show abstract

Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction

Abstract: These findings extend existing evidence linking n-3 fatty acid consumption to a reduced risk of ventricular arrhythmias by showing that a greater intake of n-3 fatty acids may be associated with low ventricular ectopy among AMI patients.

Cited by 29 publications

References 57 publications

The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment

The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment

The Fish Oil Story Remains Fishy

Association of Higher Omega-6/Omega-3 Fatty Acids in the Diet with Higher Prevalence of Metabolic Syndrome in North India

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