Association Between Muscle Mass, Leg Strength, and Fat Mass With Physical Function in Older Adults: Influence of Age and Sex

B̀ouchard, Danielle R.; Héroux, Mariane; Janssen, Ian

doi:10.1177/0898264310388562

Cited by 90 publications

(65 citation statements)

References 34 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our data did not bear out this expectation at either gait speed, confirming previous findings of similar correlations [16] . The non-discriminant predictive power of these two measures may be related to old adults being well above the 1.0 m/s clinical threshold of habitual gait speed and well below a function-affecting threshold of leg muscle strength loss [10] .…”

Section: Associations Between Leg Muscle Strength Leg Ltm and Gait supporting

confidence: 60%

“…The sporadic data are inconsistent, as knee extensor muscle thickness did not correlate ( r = -0.07) with gait speed in women aged 52-83 years [15] , whereas bone-free lean tissue mass (LTM) in the legs revealed a low but significant ( r = -0.12, p ≤ 0.01) correlation with gait speed in older adults aged 68 ± 9 years [16] . In addition, only small associations were detected between changes in leg muscle mass and changes in gait speed in 66-to 85-year-old female athletes [17] , in 25 resistancetrained women aged 71 years [18] , after a diet-exercise intervention in healthy women aged ∼ 60 years [19] , and after resistance training in 23 healthy women aged 70 years [20] .…”

mentioning

confidence: 97%

See 1 more Smart Citation

Non-Discriminant Relationships between Leg Muscle Strength, Mass and Gait Performance in Healthy Young and Old Adults

et al. 2017

View full text Add to dashboard Cite

Background: Gait speed declines with increasing age, but it is unclear if gait speed preferentially correlates with leg muscle strength or mass. Objective: We determined the relationship between gait speed and (1) leg muscle strength measured at 3 lower extremity joints and (2) leg lean tissue mass (LTM) in healthy young (age: 25 years, n = 20) and old (age: 70 years, n = 20) adults. Methods: Subjects were tested for maximal isokinetic hip, knee, and ankle extension torque, leg LTM by bioimpedance, and gait performance (i.e., gait speed, stride length) at preferred and maximal gait speeds. Results: We found no evidence for a preferential relationship between gait performance and leg muscle strength compared with gait performance and leg LTM in healthy young and old adults. In old adults, hip extensor strength only predicted habitual gait speed (R² = 0.29, p = 0.015), whereas ankle plantarflexion strength only predicted maximal gait speed and stride length (both R² = 0.40, p = 0.003). Conclusions: Gait speed did not preferentially correlate with leg muscle strength or leg LTM, favoring neither outcome for predicting mobility. Thus, we recommend that both leg muscle strength and leg LTM should be tested and trained complementarily. Further, hip and ankle extension torque predicted gait performance, and thus we recommend to test and train healthy old adults by functional integrated multiarticular rather than monoarticular lower extremity strength exercises.

show abstract

Section: Associations Between Leg Muscle Strength Leg Ltm and Gait supporting

confidence: 60%

mentioning

confidence: 97%

Non-Discriminant Relationships between Leg Muscle Strength, Mass and Gait Performance in Healthy Young and Old Adults

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The research on skeletal muscle aging in women is even more important since, compared to age-matched males, older women tend to have more severe sarcopenia, less muscle strength and power, and a greater risk for disability [2]. Moreover, since women tend to live longer than men, a greater number of older women are affected by physical disabilities.…”

Section: Introductionmentioning

confidence: 99%

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Wang

Alencar

Lin

et al. 2016

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

The molecular mechanisms of muscle weakness and sarcopenia in postmenopausal women are largely unknown. To determine the effect of a new estrogen receptor, GPR30, in the maintenance of exercise capacity and skeletal muscle function in females, the selective GPR30 agonist, G1 (100 μg/kg/day), or vehicle (V, soybean oil) was administered subcutaneously daily (n=7 per group) to ovariectomized (OVX) 27-month-old Fischer 344×Brown Norway (F344BN) female rats. Following 8 weeks of treatment, the exercise capacity (treadmill walk time to exhaustion) was reduced in OVX vs. sham rats (5.1±1.4 vs. 11.0±0.9 min, P<0.05), and chronic G1 restored exercise capacity (12.9±1.2 min; P<0.05 vs. OVX-V). Similarly, the peak twitch of electrically stimulated soleus muscles was decreased by 22% in OVX vs. sham rats (P<0.05), and G1 attenuated this decline (P<0.05). Western blot analysis showed that chronic G1 treatment attenuated OVX-associated decreases in heat shock protein (HSP) 90, HSP70, and HSP27 expressions. In vitro studies using the L6 myoblast cell line demonstrated that G1 increased mRNA levels of HSPs in cultured cells. Collectively, these data demonstrate that the activation of GPR30 mitigates the adverse effects of estrogen loss on exercise capacity and skeletal muscle contractile function in old F344BN rats. The protective effects of GPR30 might be through its upregulation of heat shock proteins in skeletal muscle.

show abstract

“…Hairi, et al, registraron una reducción significativa de la fuerza del cuádriceps cada cinco años entre los 70 y los 90 años, y encontraron que la fuerza de las piernas constituía un importante descriptor de la limitación funcional (26). Del mismo modo, Bouchard, et al, han señalado que la fuerza de las piernas es un importante predictor de la función física en adultos mayores (27). En un estudio prospectivo con personas entre los 70 y los 79 años de edad, Visser, et al, demostraron que la masa muscular escasa (área de la sección transversal más pequeña del cuádriceps), una mayor infiltración de grasa en el músculo y una menor fuerza muscular extensora de la rodilla, se asociaban con un mayor riesgo de pérdida de la movilidad en los hombres y las mujeres de más edad (28).…”

Section: Hombres Mujeresunclassified

Asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral y el grado de actividad física en octogenarios

Román¹,

Arévalo-Arévalo²,

García‐Pinillos³

2016

biomedica

View full text Add to dashboard Cite

Contribución de los autores:Pedro Á. Latorre-Román: diseño del estudio, análisis estadístico y redacción del artículo Juan Manuel Arévalo-Arévalo: diseño del estudio y recolección de datos Felipe García-Pinillos: redacción del artículo y recolección de datos Asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral y el grado de actividad física en octogenarios Pedro Á. Latorre-Román, Juan Manuel Arévalo-Arévalo, Felipe García-PinillosDepartamento de Expresión Corporal, Universidad de Jaén, Jaén, EspañaIntroducción. El envejecimiento es un proceso fisiológico complejo cuya principal característica es la progresiva pérdida de funcionalidad, lo que es posible retardar o atenuar mejorando el estado físico. Objetivo. Analizar la asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral, así como el nivel de actividad física en octogenarios. Materiales y métodos. Participaron 32 personas mayores de 80 años (hombres: 82,80±2,09 años; mujeres: 83,77±4,09 años) funcionalmente autónomas. Para su evaluación se emplearon el índice de Barthel, el Yale Physical Activity Survey y la prueba de sentarse y levantarse.Resultados. Se encontraron diferencias significativas entre sexos en la variable de área muscular (p<0,001), en la prueba de sentarse y levantarse (p=0,028) y el índice de paseo (p=0,029), con valores superiores en los varones. El área muscular y la prueba de sentarse y levantarse se correlacionaron de manera significativa con el índice de paseo (r=0,445, p<0,005 y r=0,522, p<0,001, respectivamente), y con el índice de actividad total semanal (r=0,430, p<0,005 y r=0,519, p<0,001, respectivamente). En el modelo de regresión lineal múltiple de este último índice, el área muscular y la prueba de sentarse y levantarse, solo esta última se comportó como variable predictora. Conclusiones. La fuerza muscular y la masa muscular del músculo cuádriceps mostraron una asociación significativa con el grado de actividad física en personas mayores. La fuerza muscular de las piernas fue un indicador útil para revelar la masa muscular y el grado de actividad física en estas personas, lo cual tiene relevancia en la práctica clínica.Palabras clave: anciano, índice de masa muscular, extremidad inferior, actividad motora.doi: http://dx.doi.org/10.7705/biomedica.v36i2.2654Association between leg strength and muscle cross-sectional area of the quadriceps femoris with the physical activity level in octogenarians Introduction: Aging is a complex physiological process whose main feature is the progressive loss of functionality, which may be delayed or attenuated by improving physical fitness. Objective: To determine the association between leg strength and the muscle cross-sectional area of the quadriceps femoris in relation to physical activity level in the elderly. Materials and methods: Thirty-two functionally autonomous people over 80 years (men: 82.80±2.09 years; women: 83.77±4.09 years) participated in this study. The Barth...

show abstract

Association Between Muscle Mass, Leg Strength, and Fat Mass With Physical Function in Older Adults: Influence of Age and Sex

Abstract: Leg strength and fat mass best predict physical function in older adults and the relative importance varies according to age and sex.

Cited by 90 publications

References 34 publications

Non-Discriminant Relationships between Leg Muscle Strength, Mass and Gait Performance in Healthy Young and Old Adults

Non-Discriminant Relationships between Leg Muscle Strength, Mass and Gait Performance in Healthy Young and Old Adults

Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats

Asociación entre la fuerza de las piernas y el área de sección muscular transversal del músculo cuádriceps femoral y el grado de actividad física en octogenarios

Contact Info

Product

Resources

About