Association between mitochondria and rough endoplasmic reticulum in rat liver

Montisano, D F; Cascarano, Joseph; Pickett, Cecil B.; James, Thomas W.

doi:10.1002/ar.1092030403

Cited by 50 publications

(24 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As with caveolae, the SR may appear to engulf mitochondria, and thereby create a specialized space for Ca signaling, discussed below. Although close association between ER and mitochondria has been described in other cell types (489,561), few have reported the almost complete enveloping, which appears to be a feature of smooth muscles. This aspect has been examined in detail at the EM level by Dai et al (140) in pig tracheal muscle.…”

Section: E Sr and The Mitochondriamentioning

confidence: 90%

Sarcoplasmic Reticulum Function in Smooth Muscle

Wray

Burdyga

2010

Physiological Reviews

153

134

View full text Add to dashboard Cite

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and questions concerning its roles, especially as these change with development, disease, and modulation of physiological activity. The SR's function was originally perceived to be synthetic and then that of a Ca store for the contractile proteins, acting as a Ca amplification mechanism as it does in striated muscles. Gradually, as investigators have struggled to find a convincing role for Ca-induced Ca release in many smooth muscles, a role in controlling excitability has emerged. This is the Ca spark/spontaneous transient outward current coupling mechanism which reduces excitability and limits contraction. Release of SR Ca occurs in response to inositol 1,4,5-trisphosphate, Ca, and nicotinic acid adenine dinucleotide phosphate, and depletion of SR Ca can initiate Ca entry, the mechanism of which is being investigated but seems to involve Stim and Orai as found in nonexcitable cells. The contribution of the elemental Ca signals from the SR, sparks and puffs, to global Ca signals, i.e., Ca waves and oscillations, is becoming clearer but is far from established. The dynamics of SR Ca release and uptake mechanisms are reviewed along with the control of luminal Ca. We review the growing list of the SR's functions that still includes Ca storage, contraction, and relaxation but has been expanded to encompass Ca homeostasis, generating local and global Ca signals, and contributing to cellular microdomains and signaling in other organelles, including mitochondria, lysosomes, and the nucleus. For an integrated approach, a review of aspects of the SR in health and disease and during development and aging are also included. While the sheer versatility of smooth muscle makes it foolish to have a “one model fits all” approach to this subject, we have tried to synthesize conclusions wherever possible.

show abstract

Section: E Sr and The Mitochondriamentioning

confidence: 90%

Sarcoplasmic Reticulum Function in Smooth Muscle

Wray

Burdyga

2010

Physiological Reviews

153

134

View full text Add to dashboard Cite

show abstract

“…Frequency It was initially suggested that 80% of mitochondria are in contact with ER in the liver (Montisano et al 1982). Later, more sophisticated analytical techniques revised downward this frequency and found that around 20% of mitochondria are in contact with ER at least in Hela cells (Rizzuto et al 1998).…”

Section: Important Structural Features To Take Into Account When Analmentioning

confidence: 99%

Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases

Tubbs

Rieusset

2017

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Beyond the maintenance of cellular homeostasis and the determination of cell fate, ERmitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.

show abstract

“…The specific role of Aux1p/Swa2p in regulating cortical ER inheritance was examined further by comparing the distribution of mitochondria and vacuoles in aux1/swa2⌬ and wild type. A close association between the ER and mitochondria has been described in both yeast and mammalian cells (Montisano et al 1982;Perkins et al, 1997;Prinz et al, 2000). To study the distribution of mitochondria in the aux1/swa2⌬ mutant, a plasmid (pYDY104) expressing a mitochondrial targeting sequence fused to RFP (Mozdy et al, 2000) was transformed into wild-type and mutant cells.…”

Section: Inheritance Of Other Organelles Appears To Be Unaffected In mentioning

confidence: 99%

Aux1p/Swa2p Is Required for Cortical Endoplasmic Reticulum Inheritance inSaccharomyces cerevisiae

Pypaert²,

Novick³

et al. 2001

MBoC

View full text Add to dashboard Cite

In the yeast Saccharomyces cerevisiae, the endoplasmic reticulum (ER) is found at the periphery of the cell and around the nucleus. The segregation of ER through the mother-bud neck may occur by more than one mechanism because perinuclear, but not peripheral ER, requires microtubules for this event. To identify genes whose products are required for cortical ER inheritance, we have used a Tn3-based transposon library to mutagenize cells expressing a green fluorescent proteintagged ER marker protein (Hmg1p). This approach has revealed that AUX1/SWA2 plays a role in ER inheritance. The COOH terminus of Aux1p/Swa2p contains a J-domain that is highly related to the J-domain of auxilin, which stimulates the uncoating of clathrin-coated vesicles. Deletion of the J-domain of Aux1p/Swa2p leads to vacuole fragmentation and membrane accumulation but does not affect the migration of peripheral ER into daughter cells. These findings suggest that Aux1p/Swa2p may be a bifunctional protein with roles in membrane traffic and cortical ER inheritance. In support of this hypothesis, we find that Aux1p/Swa2p localizes to ER membranes.

show abstract

Association between mitochondria and rough endoplasmic reticulum in rat liver

Cited by 50 publications

References 25 publications

Sarcoplasmic Reticulum Function in Smooth Muscle

Sarcoplasmic Reticulum Function in Smooth Muscle

Metabolic signaling functions of ER–mitochondria contact sites: role in metabolic diseases

Aux1p/Swa2p Is Required for Cortical Endoplasmic Reticulum Inheritance inSaccharomyces cerevisiae

Contact Info

Product

Resources

About