Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study

Araújo, Thália Velho Barreto de; Ximenes, Ricardo Arraes de Alencar; Miranda-Filho, Demócrito de Barros; Souza, Wayner Vieira de; Montarroyos, Ulísses Ramos; Melo, Ana Paula Lopes de; Valongueiro, Sandra; Albuquerque, Maria de Fátima Pessoa Militão de; Braga, Cynthia; Brandão-Filho, Sinval Pinto; Cordeiro, Marli Tenório; Vázquez, Eva García; Cruz, Danielle Di Cavalcanti Souza; Henriques, Cláudio Maierovitch Pessanha; Bezerra, Luciana Caroline Albuquerque; Castanha, Priscila M. S.; Dhália, Rafael; Marques, Ernesto T. A.; Martelli, Celina Maria Turchi; Rodrigues, Laura C.; Dhalia, C. de B. C.; Santos, Marcela Lopes; Cortés, Fanny; Oliveira, Wanderson Kleber de; Coelho, Giovanini Evelim; Cortez-Escalante, Juan José; Melo, Carlos Frederico de Albuquerque de Campelo; Ramón-Pardo, Pilar; Aldighieri, Sylvain; Méndez‐Rico, Jairo; Espinal, Marcos; Torres, Leuridan Cavalcante; Hazin, Adriano Nassri; Linden, Ana van der; Coentro, Mônica; Dimech, George Santiago; Assunção, Romildo Siqueira de; Carvalho, Patrícia Ismael de; Oliveira, Valdete Felix de

doi:10.1016/s1473-3099(17)30727-2

Cited by 293 publications

(250 citation statements)

References 29 publications

Supporting

Mentioning

216

Contrasting

Unclassified

Order By: Relevance

“…Zika virus-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika virus infection also were identified in children with negative Zika virus NAT or IgM test results. These finding are consistent with other reports of infants with clinical findings suggestive of possible congenital Zika syndrome but with negative laboratory results ( 2 , 20 , 22 ). …”

Section: Conclusion and Commentssupporting

confidence: 93%

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Rice¹,

Galang²,

Roth³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

190

237

View full text Add to dashboard Cite

IntroductionZika virus infection during pregnancy causes serious birth defects and might be associated with neurodevelopmental abnormalities in children. Early identification of and intervention for neurodevelopmental problems can improve cognitive, social, and behavioral functioning.MethodsPregnancies with laboratory evidence of confirmed or possible Zika virus infection and infants resulting from these pregnancies are included in the U.S. Zika Pregnancy and Infant Registry (USZPIR) and followed through active surveillance methods. This report includes data on children aged ≥1 year born in U.S. territories and freely associated states. Receipt of reported follow-up care was assessed, and data were reviewed to identify Zika-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika virus infection.ResultsAmong 1,450 children of mothers with laboratory evidence of confirmed or possible Zika virus infection during pregnancy and with reported follow-up care, 76% had developmental screening or evaluation, 60% had postnatal neuroimaging, 48% had automated auditory brainstem response-based hearing screen or evaluation, and 36% had an ophthalmologic evaluation. Among evaluated children, 6% had at least one Zika-associated birth defect identified, 9% had at least one neurodevelopmental abnormality possibly associated with congenital Zika virus infection identified, and 1% had both.ConclusionOne in seven evaluated children had a Zika-associated birth defect, a neurodevelopmental abnormality possibly associated with congenital Zika virus infection, or both reported to the USZPIR. Given that most children did not have evidence of all recommended evaluations, additional anomalies might not have been identified. Careful monitoring and evaluation of children born to mothers with evidence of Zika virus infection during pregnancy is essential for ensuring early detection of possible disabilities and early referral to intervention services.

show abstract

Section: Conclusion and Commentssupporting

confidence: 93%

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Rice¹,

Galang²,

Roth³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

190

237

View full text Add to dashboard Cite

show abstract

“…Em alguns casos, pode levar à síndrome de Guillain-Barré, doença autoimune neurológica, que causa fraqueza muscular generalizada e paralisia (Lima-Camara, 2016). Além disso, o Brasil foi o primeiro país a identificar e confirmar uma possível relação entre infecção por ZIKV em mulheres grávidas e ocorrência de síndrome congênita do Zika nos recém-nascidos, que acarretarão custos diretos e indiretos ao longo de toda a vida (Araújo et al, 2017).…”

Section: Introductionunclassified

Aedes aegypti e sociedade: o impacto econômico das arboviroses no Brasil

Teich¹,

Arinelli²,

Fahham³

2017

JBES

View full text Add to dashboard Cite

RESUMOObjetivo: Arboviroses são motivo de preocupação para a saúde pública, com impactos clínicos e econômicos negativos. Este estudo teve o objetivo de avaliar custos de combate ao vetor, custos médicos diretos e custos indiretos associados à dengue clássica, dengue hemorrágica, chikungunya e infecção pelo Zika vírus (ZIKV) no Brasil, para o ano de 2016. Métodos: As análises quantificaram custos relacionados ao combate ao vetor, como repasses de recursos federais e aquisição de pesticidas, custos médicos diretos para tratamento das doenças por meio de condutas de manejo ambulatorial e hospitalar e custos indiretos relacionados ao absenteísmo, calculados com base em estudos publicados ou de estimativa de anos de vida ajustados por incapacidade (AVAIs). Resultados: O investimento para combate ao vetor foi de R$ 1,5 bilhão no Brasil e o custo reportado pelo governo federal para aquisição de inseticidas e larvicidas foi de R$ 78,6 milhões. Custos médicos diretos geraram gasto total de R$ 374 milhões. Febre chikungunya apresentou o maior número de AVAIs perdidos por episódio da doença (0,036 AVAI), seguido pela infecção por ZIKV (0,005 AVAI). O custo indireto total foi estimado em R$ 431 milhões. Custos totais com o manejo das arboviroses atingiram impacto de R$ 2,3 bilhões no Brasil, em 2016. Minas Gerais, São Paulo, Bahia e Rio de Janeiro apresentaram os maiores custos. Conclusões: Arboviroses geram consideráveis impactos econômico e social ao Brasil. Custos de combate ao vetor, custos médicos diretos e custos indiretos representaram 2% do orçamento previsto para a saúde no País, em 2016. ABSTRACTObjective: Arboviruses are a cause of concern for public health, with negative clinical and economic impacts. The objective of this study was to evaluate costs of vector control, direct medical costs and indirect costs associated with classical dengue fever, dengue hemorrhagic fever, chikungunya and Zika virus infection in Brazil for the year 2016. Methods: The analyzes quantified costs related to vector control, such as federal resource transfers and acquisition of pesticides, direct medical costs related to diseases treatment through outpatient and hospital management, and indirect costs related to absenteeism, calculated from published studies or estimates of disability-adjusted life years (DALYs). Results: The investment for vector combat was R$ 1.5 billion in Brazil and the cost reported by federal government for the acquisition of insecticides and larvicides was R$ 78.6 million. Direct medical costs generated total expenses of R$ 374 million. Fever chikungunya presented the highest number of DALYs lost per episode of disease (0.036 DALYs), followed by Zika virus infection (0.005 DALYs). Total indirect cost was estimated at R$ 431 million. Total costs with the management of arboviroses reached an impact of R$ 2.3 billion in Brazil for 2016. Minas Gerais, São Paulo, Bahia and Rio de Janeiro presented the highest costs. Conclusions: Arboviroses generate considerable economic and social impact to Brazil. Vector combat c...

show abstract

“…In the case‐control study of,7 only 11% of the microcephaly cases tested positive for Zika virus‐specific IgM in serum. The timeframe for detection of ZIKV specific IgM and IgG is uncertain.…”

Section: Discussionmentioning

confidence: 95%

“…The timeframe for detection of ZIKV specific IgM and IgG is uncertain. The sensitivity and specificity of these tests are not known, but they seem to be low 7, 8…”

Section: Discussionmentioning

confidence: 99%

Congenital Zika syndrome phenotype in a child born in Brazil in December 2011

Coelho

Silva²,

Pinho³

et al. 2018

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study

Abstract: Brazilian Ministry of Health, Pan American Health Organization, and Enhancing Research Activity in Epidemic Situations.

Cited by 293 publications

References 29 publications

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Vital Signs:Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018

Aedes aegypti e sociedade: o impacto econômico das arboviroses no Brasil

Congenital Zika syndrome phenotype in a child born in Brazil in December 2011

Contact Info

Product

Resources

About