Association Between Metabolic Syndrome and Male Overactive Bladder in a Japanese Population Based on Three Different Sets of Criteria for Metabolic Syndrome and the Overactive Bladder Symptom Score

Ohgaki, Kenji; Horiuchi, Kazutaka; Kondo, Yukihiro

doi:10.1016/j.urology.2012.03.006

Cited by 29 publications

(28 citation statements)

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“…Since serum CRP indicates chronic inflammation, patients with elevated serum CRP levels and LUTS might have chronic inflammation in the lower urinary tract or other systems. Epidemiological studies have revealed a high prevalence rate of OAB in patients with metabolic syndrome, obesity, chronic heart failure and diabetes [26]–[28]. Systemic inflammation might also increase circulating cytokines and cause OAB [29], [30].…”

Section: Discussionmentioning

confidence: 99%

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

2014

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ObjectiveChronic inflammation is considered as one of the contributing mechanisms of lower urinary tract symptoms (LUTS). Serum C-reactive protein (CRP) level is the widely used biomarker of inflammatory status. This study investigated the association between serum CRP level in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) before and after medical treatment.MethodsA total of 853 men with BPH and LUTS were enrolled. All patients completed the International Prostate Symptoms Score (IPSS) questionnaire and urological examinations. The parameters of uroflowmetry (maximum flow rate, Qmax; voided volume, VV), post-void residual (PVR), total prostate volume (TPV) and transition zone index (TZI), serum prostate specific antigen (PSA), and serum CRP levels were obtained. All patients were treated with alpha-blocker or antimuscarinic agent based on the IPSS voiding to storage subscore ratio (IPSS-V/S). Correlation analyses were performed between serum CRP levels with age, IPSS, TPV, TZI, Qmax, PVR, VV, PSA and between baseline and post treatment.ResultsThe mean age was 66.9±11.6 years old and the mean serum CRP levels were 0.31±0.43 mg/dL. Univariate analyses revealed serum CRP levels were significantly associated with age (p<0.001), PSA levels (p = 0.005) and VV (p = 0.017), but not significantly associated with TPV (p = 0.854) or PVR (p = 0.068). CRP levels were positively associated with urgency (p<0.001) and nocturia (p<0.001) subscore of IPSS, total IPSS (p = 0.008) and storage IPSS (p<0.001) and negatively associated with IPSS- V/S ratio (p = 0.014). Multivariate analyses revealed that serum CRP levels were significantly associated with age (p = 0.004) and storage IPSS subscore p<0.001). Patients with IPSS-V/S<1 and treated with tolterodine for 3 months had significant decrease of CRP levels after treatment.ConclusionSerum CRP levels are associated with storage LUTS and sensory bladder disorders, suggesting chronic inflammation might play a role in the patients with storage predominant LUTS.

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Section: Discussionmentioning

confidence: 99%

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

2014

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“…LUTS were assessed using the OABSS questionnaire and 3-day consecutive voiding diary with the Indevus Urgency Severity Scale (IUSS). OAB was defined as OABSS ≥3 with an urgency score of ≥2 (9, 10). In addition, scores on the OABSS of ≤5 were defined as mild, those of 6-11 as moderate, and those of ≥12 as severe (9, 10).…”

Section: Methodsmentioning

confidence: 99%

Correlation between overactive bladder symptom score and neuropsychological parameters in Alzheimer’s disease patients with lower urinary tract symptom

et al. 2017

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Purpose To examine an association between the overactive bladder symptom score (OABSS) and neuropsychological parameters. Moreover, we investigate the factors that affect each item in the questionnaire.Materials and Methods A total of 376 patients (males: 184; females: 192) with probable Alzheimer’s disease (AD) were recruited. Cognitive testing was conducted using the Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR) scale, Global Deterioration Scale (GDS), and Barthel Activities of Daily Living (ADL). Lower urinary tract symptom (LUTS) was assessed using OABSS and voiding diary.Results The prevalence of overactive bladder (OAB) (defined as OABSS ≥3 with an urgency score of ≥2) in patients with AD was 72.6%. Among the OAB subjects, the most common severity of symptom was moderate (72.6%), followed by mild (21.2%), and severe (5.8%). It was found that OABSS had a very high correlation with aging (r=0.75; p<0.001). When compared with neuropsychological parameters, it was found that OABSS was highly correlated with the CDR scores (r=0.446; p<0.001). However, no significant correlation was found between the changes in OABSS scores and those in other neuropsychological parameters. Based on the individual symptom scores, urgency incontinence was highly correlated with the CDR scores (r=0.43; p<0.001).Conclusions OABSS is a useful tool in assessing AD patients with LUTS. There was a consistent positive association between OABSS severity, including urgency incontinence, and CDR scores.

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“…This finding suggested that urinary ATP levels in OAB patients could reflect urothelial release. In a fructose-fed animal model of metabolic syndrome, which is associated with OAB [102, 103], P2X3 expression was upregulated in the urothelium and intravesically infused ATP induced greater detrusor overactivity in fructose fed animals compared to controls [104]. This suggested increased urothelial purinergic signaling in the fructose fed animals.…”

Section: Urothelial Abnormalities In Nonneurogenic Idiopathic Oabmentioning

confidence: 99%

Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders

Keay

Birder

Chai

2014

BioMed Research International

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Understanding of the role of urothelium in regulating bladder function is continuing to evolve. While the urothelium is thought to function primarily as a barrier for preventing injurious substances and microorganisms from gaining access to bladder stroma and upper urinary tract, studies indicate it may also function in cell signaling events relating to voiding function. This review highlights urothelial abnormalities in bladder pain syndrome/interstitial cystitis (BPS/IC), feline interstitial cystitis (FIC), and nonneurogenic idiopathic overactive bladder (OAB). These bladder conditions are typified by lower urinary tract symptoms including urinary frequency, urgency, urgency incontinence, nocturia, and bladder discomfort or pain. Urothelial tissues and cells from affected clinical subjects and asymptomatic controls have been compared for expression of proteins and mRNA. Animal models have also been used to probe urothelial responses to injuries of the urothelium, urethra, or central nervous system, and transgenic techniques are being used to test specific urothelial abnormalities on bladder function. BPS/IC, FIC, and OAB appear to share some common pathophysiology including increased purinergic, TRPV1, and muscarinic signaling, increased urothelial permeability, and aberrant urothelial differentiation. One challenge is to determine which of several abnormally regulated signaling pathways is most important for mediating bladder dysfunction in these syndromes, with a goal of treating these conditions by targeting specific pathophysiology.

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Association Between Metabolic Syndrome and Male Overactive Bladder in a Japanese Population Based on Three Different Sets of Criteria for Metabolic Syndrome and the Overactive Bladder Symptom Score

Cited by 29 publications

References 28 publications

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Increased Serum C-Reactive Protein Level Is Associated with Increased Storage Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia

Correlation between overactive bladder symptom score and neuropsychological parameters in Alzheimer’s disease patients with lower urinary tract symptom

Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders

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