Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis

Du, Wurong; Guo, Kaibo; Jin, Han Seung; Sun, Leitao; Ruan, Shanming; Song, Qiaoling

doi:10.3389/fonc.2022.928619

Cited by 5 publications

(3 citation statements)

References 56 publications

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“…The methods of the statistics are generally consistent with those used in the previous meta-analysis of cohort studies ( 30 ). We used RR and corresponding 95% CI as the general measure for association between GV at baseline and the incidence of AF during follow-up.…”

Section: Methodsmentioning

confidence: 84%

Glycemic variability and the risk of atrial fibrillation: a meta-analysis

Wang

Zhong

2023

Front. Endocrinol.

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BackgroundGlycemic variability (GV) has been associated with vascular complications in patients with diabetes. However, the relationship between GV and risk of atrial fibrillation (AF) remains not fully determined. We therefore conducted a systematic review and meta-analysis to evaluate the above association.MethodsMedline, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure were searched for longitudinal follow-up studies comparing the incidence of AF between patients with higher versus lower GV. A random-effects model incorporating the potential heterogeneity was used to pool the results.ResultsNine cohort studies with 6,877,661 participants were included, and 36,784 (0.53%) participants developed AF during follow-up. Pooled results showed that a high GV was associated with an increased risk of AF (risk ratio [RR]: 1.20, 95% confidence interval [CI]: 1.11 to 1.30, p < 0.001, I2 = 20%). Subgroup analyses suggested consistent association between GV and AF in prospective (RR: 1.29, 95% CI: 1.05 to 1.59, p = 0.01) and retrospective studies (RR: 1.18, 95% CI: 1.08 to 1.29, p = 0.002), in diabetic (RR: 1.24, 95% CI: 1.03 to 1.50, p = 0.03) and non-diabetic subjects (RR: 1.13, 95% CI: 1.00 to 1.28, p = 0.05), in studies with short-term (RR: 1.25, 95% CI: 1.11 to 1.40, p < 0.001) and long-term GV (RR: 1.18, 95% CI: 1.05 to 1.34, p = 0.006), and in studies with different quality scores (p for subgroup difference all > 0.05).ConclusionA high GV may predict an increased risk of AF in adult population.

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Section: Methodsmentioning

confidence: 84%

Glycemic variability and the risk of atrial fibrillation: a meta-analysis

Wang

Zhong

2023

Front. Endocrinol.

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“…Researches regarding the roles of metabolic disorders in the pathogenesis and progression of cancer have become a hotspot in recent decades. As a syndrome integrating multiple common metabolic disorders, MetS has been shown to be closely related to the incidence of multiple cancers (36)(37)(38)(39)(40), but not all (41). Besides, in view of the high prevalence of MetS in patients with confirmed diagnosis of cancer (42), it is also important to determine the influence of MetS on survival of these patients.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis

2023

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BackgroundMetabolic syndrome (MetS) has been related to a high incidence of hepatocellular carcinoma (HCC). However, the influence of MetS on survival of patients with HCC is still unclear. We performed a systematic review and meta-analysis to evaluate the association between MetS and survival of HCC patients.MethodsA search of PubMed, Embase, and Web of Science retrieved relevant cohort studies from the inception of the databases to October 16, 2022. Data collection, literature search, and statistical analysis were carried out independently by two authors. We pooled the results using a random-effects model that incorporates heterogeneity.ResultsIn the meta-analysis, 8080 patients with HCC were included from ten cohort studies, and 1166 patients (14.4%) had MetS. Eight studies included patients treated primarily with radical hepatectomy, one study with patients receiving sorafenib, and another study included patients who were treated with radical hepatectomy or non-surgical treatments. Pooled results showed that MetS was associated with poor overall survival (OS, risk ratio [RR]: 1.21, 95% confidence interval [CI]:1.08 to 1.37, p = 0.001; I2 = 32%) and progression-free survival (PFS, RR: 1.33, 95% CI: 1.18 to 1.49, p < 0.001, I2 = 14%). Influencing analysis by excluding one study at a time showed consistent results (p all < 0.05). Subgroup analyses showed similar results in studies with MetS diagnosed with the National Cholesterol Education Program Adult Treatment Panel III or International Diabetes Federal criteria, and in studies with mean follow-up durations < or ≥ 3.5 years (p for subgroup difference all > 0.05).ConclusionIn patients with HCC, MetS may be a risk factor of poor OS and PFS, particularly for those after radical hepatectomy.

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“…Metabolic syndrome is characterized by obesity, insulin resistance, hypertension, and hyperlipidemia (1) and is associated with the progression of diseases such as type 2 diabetes mellitus, cardiovascular disease, and nonalcoholic steatohepatitis (3,4). Recent epidemiological studies have indicated that metabolic syndrome is also closely associated with the development of malignant tumors such as liver, bladder, renal, endometrial, pancreatic, and breast cancers (5)(6)(7)(8)(9)(10)(11). Moreover, recovery from metabolic syndrome by making lifestyle adjustments is associated with a reduced risk of pancreatic cancer compared to persistent metabolic syndrome, implying that alterations in metabolic syndrome can affect pancreatic cancer risk (12).…”

Section: Introductionmentioning

confidence: 99%

Hypertension and hyperglycaemia are positively correlated with local invasion of early cervical cancer

Shen,

Zhao,

et al. 2023

Front. Endocrinol.

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BackgroundMetabolic disorders are involved in the development of numerous cancers, but their association with the progression of cervical cancer is unclear. This study aims to investigate the association between metabolic disorders and the pathological risk factors and survival in patients with early cervical cancer.MethodsPatients with FIGO IB1 (2009) primary cervical cancer who underwent radical hysterectomy and systematic pelvic lymph node dissection at our institution from October 2014 to December 2017 were included retrospectively. Clinical data regarding the metabolic syndrome and surgical pathology of the patient were collected. The correlations between metabolic disorders (hypertension, hyperglycemia, and obesity) and clinicopathological characteristics as well as survival after surgery were analyzed.ResultsThe study included 246 patients with clinical IB1 cervical cancer, 111 (45.1%) of whom had at least one of the comorbidities of hypertension, obesity, or hyperglycemia. Hypertension was positively correlated with parametrial invasion and poorly differentiated histology; hyperglycemia was positively correlated with stromal invasion; obesity was negatively associated with lymph node metastasis; but arbitrary disorder did not show any correlation with pathologic features. Hypertension was an independent risk factor for parametrial invasion (OR=6.54, 95% CI: 1.60-26.69); hyperglycemia was an independent risk factor for stromal invasion (OR=2.05, 95% CI: 1.07-3.95); and obesity was an independent protective factor for lymph node metastasis (OR=0.07, 95% CI: 0.01-0.60). Moreover, the patients with hypertension had a significantly lower 5-year OS rate (70.0% vs. 95.3%, P<0.0001) and a significantly lower 5-year PFS rate than those without hypertension (70.0% vs. 91.2%, P=0.010).ConclusionHypertension and hyperglycemia are positively associated with local invasion of early cervical cancer, which need to be verified in multi-center, large scale studies.

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Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis

Cited by 5 publications

References 56 publications

Glycemic variability and the risk of atrial fibrillation: a meta-analysis

Glycemic variability and the risk of atrial fibrillation: a meta-analysis

Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis

Hypertension and hyperglycaemia are positively correlated with local invasion of early cervical cancer

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