Association Between Metabolic and Hormonal Derangements and Professional Exposure to Urban Pollution in a High Intensity Traffic Area

Abstract

Rationale: Studies suggest a relation between exposure to air particulate matter (PM) 2.5 pollution and greater cardiovascular morbidity, as well as increased risk for obesity and diabetes. We aimed to identify association(s) between nutritional and metabolic status and exposure to environmental pollution in a cohort of policemen exposed to high levels of air pollution. Methods: We considered adult municipal policemen, working in an urban area at high-traffic density with documented high levels of air PM 2.5 (exposed group) compared to non-exposed policemen. Clinical characteristics, including the presence/absence of metabolic syndrome, were recorded, and serum biomarkers, including adiponectin, leptin, and ghrelin, were assessed. Conclusions: Exposure to air PM pollution was associated with lower levels of adiponectin in adult males with metabolic syndrome.

Micro- and Nanosized Substances Cause Different Autophagy-Related Responses

“…DEP induce macrophage activation and dysfunction [ 177 ]. Exposure to a high-intensity traffic area affects metabolism and hormones [ 178 ]. Traffic-related PM induces autophagy markers, such as p62, Beclin 1, and LC3, in HK-2 human kidney tubular epithelial cells and rat kidney tissues [ 179 ].…”