Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis

Abstract

Background: Systemic lupus erythematosus (SLE) may be characterized by periods of remissions and chronic or acute relapses. The complexity of clinical presentation of the SLE patients leads to incorrect evaluation of disease activity. Mean platelet volume (MPV) has been studied as a simple inflammatory marker in several diseases. There is no study in the literature about MPV levels in adult SLE patients with arthritis. Objectives: We aimed to investigate the MPV levels in the SLE population with arthritis during and between activations. Methods: The study consisted of 44 SLE patients with arthritis in activation period (Group 1), the same 44 SLE patients with arthritis in remission period (Group 2) and 44 healthy controls (Group 3). Erythrocyte sedimentation rate (ESR), creactive protein (CRP), white blood cell count, platelet count, and mean platelet volume (MPV) levels were retrospectively recorded from patient files. Results: The mean ages of the SLE subjects were 42 ± 16 years, while the mean ages of controls was 41 ± 17 years. MPV was significantly lower in Group 1(7.66±0.89fL) than in Group 2 (8.61±1.06 fL) and Group 3(8.62±1.11fL) (p<0.0001). The differences between groups reached statistical significance. Conclusions: We suggest that MPV levels decrease in patients with arthritis of SLE activation when compared to the same patients in remission and healthy controls.

Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in Patients with Lichen Planus

“…Furthermore, it was reported that MPV levels showed a positive correlation with disease activity and MPV levels decreased after psoriasis treatment [18]. In the study of Safak et al [28], MPV values of systemic lupus erythematosus patients in the active arthritis period were significantly lower than those of SLE patients in remission and a control group. On the other hand, the current study revealed that PDW levels were higher and MPV values were lower in the LP group compared to the healthy controls.…”

Association of Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume with Systemic Lupus Erythematosus Disease Activity: A Meta-analysis

“…One of these was excluded because they included other diseases [31]. Thus, nine articles met the inclusion criteria [3,[10][11][12][13][14][15][16][17] (Table 1, Figure 1). One report contained data on two different groups [12], so we analyzed these studies independently.…”

“…Studies on NLR, PLR, and MPV in SLE patients compared to healthy controls, on the relationship between NLR, PLR, and MPV levels and SLE activity, and on the association of NLR with renal involvement in SLE have reported controversial results [3,[10][11][12][13][14][15][16][17]. This may be because of the small sample sizes, low statistical power, and/or the presence of clinical heterogeneity.…”

Editorial

“…It seems to be quite low in patients with SLE. 22 Keeping in China, Duan et al hypothesize that colon cancer might be originating from disputed bile acid homeostasis. 23 South African workers on the other hand 24 report dyslipidemia and anthropometric indicators among black/white adolescents.…”