Association between mean platelet volume and cardiovascular disease in obstructive sleep apnea syndrome

Abstract

Objectives: Obstructive sleep apnea syndrome is associated with cardiovascular diseases. Mean platelet volume has emerged as a marker of prothrombotic conditions and cardiovascular risk. The aim of this study was to investigate the association between the mean platelet volume and cardiovascular diseases in patients with obstructive sleep apnea syndrome. Methods: The medical records of 207 patients were analyzed. Obstructive sleep apnea syndrome was diagnosed by polygraphy, and patients were classified according to apnea–hypopnea index: control group: individuals with simple snoring (apnea–hypopnea index < 5), mild obstructive sleep apnea syndrome group (5 ⩽ apnea–hypopnea index < 15), moderate obstructive sleep apnea syndrome group (15 ⩽ apnea–hypopnea index < 30), and severe obstructive sleep apnea syndrome group (apnea–hypopnea index ⩾ 30). Mean platelet volume was obtained from medical records. Cardiovascular diseases were defined if patients had hypertension, heart failure, coronary artery disease, or arrythmia. The independent predictors related to cardiovascular diseases in obstructive sleep apnea syndrome were determined by using multiple logistic regression analysis. Results: Of the patients, 175 were included in the analysis. Sixty-three (36%) were males and 112 (64%) were females. The mean age was 51.85 ± 11 years. There were, 26 (14.9%), 53 (30.3%), 38 (21.7%), and 58 (33.1%) participants in the simple snoring, mild, moderate, and severe obstructive sleep apnea syndrome groups, respectively. Cardiovascular diseases were significantly different between the four groups ( p = 0.014). Mean platelet volume in severe obstructive sleep apnea syndrome group was significantly higher than in mild or moderate obstructive sleep apnea syndrome group and simple snoring group ( p < 0.05). Moreover, there was a positive correlation between mean platelet volume levels and apnea–hypopnea index ( r = 0.424; p < 0.001). The independent predictors of cardiovascular diseases in obstructive sleep apnea syndrome were age ( p < 0.001; odds ratio = 1.134; confidence interval: 1.072–1.2), body mass index ( p = 0.012; odds ratio: 1.105; confidence interval: 1.022–1.194), and mean platelet volume ( p < 0.001; odds ratio: 2.092; confidence interval: 1.386–3.158). Conclusion: The present study demonstrated that there is an association between mean platelet volume levels and cardiovascular diseases in patients with obstructive sleep apnea syndrome.

Association between mean platelet volume and obstructive sleep apnea-hypopnea syndrome: A systemic review and meta-analysis

“…Among these, three were review articles, three were letters to the editors, seven lacked available data, and two involved animal experiments. Finally, 31 articles (_((((xxx))))_) [17,20,21, were included in the meta-analysis. The study involved 3604 patients and 1165 control individuals.…”

“…Additionally, 19 articles (_((((xxx))))_) [17, 20, 21, 32, 34-41, 44, 46, 47, 49, 50, 52, 56] reported the Pearson or Spearman correlation coefficients of MPV with various sleep monitoring parameters (AHI: n = 17, mean arterial oxygen saturation [mean SaO 2 ]: n = 4, ODI: n = 5, sleep efficiency: n = 2, SaO 2 <90%: n = 8, LSaO 2 : n = 7). Furthermore, three articles [20,35,43] provided adjusted ORs for the association between MPV and the occurrence of CVDs in patients with OSAHS (two articles focused on coronary heart disease and one article on atrial fibrillation). Fig 1 presents the literature screening process.…”

“…In individuals with OSAHS, a substantial increase in MPV has been demonstrated to correlate positively with the severity of the disease. The variations in MPV values in individuals with OSAHS may be attributed to the activation of pro-inflammatory factors induced by intermittent hypoxia [20,21].…”