Association Between Macroscopic Appearance of Liver Lesions and Liver Histology in Dogs With Splenic Hemangiosarcoma: 79 Cases (2004–2009)

Clendaniel, Daphne C; Sivacolundhu, Ramesh K.; Sørenmo, Karin U.; Donovan, Taryn A.; Turner, Avenelle I.; Arteaga, Theresa; Bergman, Philip J.

doi:10.5326/jaaha-ms-6059

Cited by 20 publications

(35 citation statements)

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“…The present study also documents that 48% of dogs with SM and HM have malignant pathology at both sites. Of the 69 dogs in our study that were diagnosed with splenic HSA, 46 (66.7%) had HSA diagnosed in the liver; this is comparable to the results reported by Clendaniel et al [ 11 ] where 29 of 58 (50%) of dogs with gross liver and splenic lesions had splenic HSA metastasis to the liver.…”

Section: Main Textsupporting

confidence: 89%

“…The identification of concurrent SM and HM poses a conundrum to clinicians. While the incidence of splenic malignancy in SM and non-traumatic hemoabdomens has been well-documented [ 1 , 2 , 16 , 17 ], only two studies have looked at the association of HM in dogs with splenic HSA [ 11 , 18 ]. Our study is the first to report the prevalence of benign versus malignant masses in dogs with concurrent SM and HM undergoing splenectomy.…”

Section: Main Textmentioning

confidence: 99%

“…Further prospective studies are warranted and should be directed at quantification and characterization of SM and HM with different imaging modalities and gross examination. Clendaniel et al [ 11 ] previously noted that multiple nodules, dark-colored nodules, and actively bleeding nodules were highly associated with malignancy of the liver. A study utilizing contrast harmonic ultrasonography of splenic masses and liver nodules showed that it was 100% sensitive and specific for differentiating a benign vs malignant processes of the liver; however, the same study found that benign and malignant processes of the spleen were indistinguishable utilizing the same modality [ 15 ].…”

Section: Main Textmentioning

confidence: 99%

“…[ 6 – 9 ]. The presence of a concurrent hepatic mass or masses (HM) with a splenic mass or masses (SM) has been reported to be associated with a metastatic disease process [ 10 , 11 ]. Hemangiosarcoma and other malignant splenic neoplasms have been reported to metastasize to the liver, via splenic venous blood, lymphatic drainage, or transcoelomic metastasis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012–2016)

et al. 2018

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ObjectiveTo investigate the histopathologic characteristics of concurrent splenic and liver masses in dogs undergoing splenectomy and liver mass biopsy/resection. Medical records of 125 client-owned dogs found to have splenic mass or masses and a liver mass or masses during surgery were examined. Signalment (age, sex, breed), body weight, and results of histopathology were recorded for all dogs.ResultsTwenty-seven percent (34/125) of the dogs in this study had no evidence of malignancy in either the liver or the spleen. Sixty of 125 dogs (48.0%) had malignancy in the spleen and liver, and 56 (56/60, 93.3%) of those dogs had the same malignancy in both organs. Signalment was similar to that in other reports of splenic pathology. In this clinical population of dogs, 27% of dogs with concurrent gross splenic and liver masses discovered intraoperatively had benign lesions in both locations and therefore had a favorable prognosis.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3220-1) contains supplementary material, which is available to authorized users.

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Section: Main Textsupporting

confidence: 89%

Section: Main Textmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012–2016)

et al. 2018

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“…Only 50% of dogs with grossly abnormal livers had hemangiosarcoma metastasis, and no dog with a grossly normal liver had metastasis that was detected by liver histopathology (CLENDANIEL et al, 2014). In accordance with our study, the use of liver IOUS might improve metastatic assessment and local staging in dogs with splenic hemangiosarcoma.…”

Section: Discussionsupporting

confidence: 71%

Intraoperative ultrasonography in nine dogs with intra-abdominal neoplasm suspect

Silva

Vieira

et al. 2017

Cienc. Rural

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Intraoperative ultrasonography (IOUS) is used in medicine for diagnosis and guidance during oncologic surgery. The aims of this study were to assess the performance, feasibility, advantages and difficulties of the IOUS technique in dogs with suspected intra-abdominal tumors. The study included nine client-owed dogs that had suspected intra-abdominal tumors (spleen, liver or bowel) based on transabdominal ultrasound examination and that were subsequently referred for exploratory laparotomy surgery. During surgery, IOUS was performed; results of preoperative transabdominal ultrasonography, inspection by the surgeon and IOUS were compared on a case-by-case basis. IOUS was helpful in determining lesion resection in all cases. Lesions detected solely by the use of IOUS were observed in seven out of nine cases. Analysis of these cases demonstrated that IOUS can be a tool to assist during oncology surgery on the liver, spleen or bowel. Dogs with hepatic tumors can have small non-palpable intraparenchymal nodules, which may be visible by IOUS.

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Canine and feline haemangiosarcoma

2021

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Introduction: Haemangiosarcoma (HSA) is a malignant neoplasm of dogs and cats that is suspected to originate from a pluripotent bone marrow progenitor with a complex and multifactorial pathogenesis. Approach: Pertinent literature was identified, reviewed, and summarized for inclusion in the manuscript. Results/Interpretation: Dogs are more frequently diagnosed with HSA than cats, and primary sites of this disease include dermal, subcutaneous/ intramuscular, and visceral (most commonly the spleen). Dogs and cats with HSA generally have a poor prognosis owing to the rapid and widespread metastasis typically associated with this disease. However, some forms such as cutaneous HSA behave in a less aggressive fashion with improved outcomes. Surgical excision and anthracycline-based chemotherapy remain the mainstays of treatment, although novel treatment modalities are currently under investigation for potential roles in treatment of this disease. Conclusion:This review aims to describe the clinical presentation and progression of the various forms of HSA in dogs and cats as well as to provide a systematic review of the veterinary literature with a focus on the various published treatment options and associated outcomes.

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Association Between Macroscopic Appearance of Liver Lesions and Liver Histology in Dogs With Splenic Hemangiosarcoma: 79 Cases (2004–2009)

Cited by 20 publications

References 18 publications

Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012–2016)

Histopathologic characteristics of biopsies from dogs undergoing surgery with concurrent gross splenic and hepatic masses: 125 cases (2012–2016)

Intraoperative ultrasonography in nine dogs with intra-abdominal neoplasm suspect

Canine and feline haemangiosarcoma

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