Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity

Kuriyama, Nagato; Inaba, Masaaki; Ozaki, Etsuko; Yoneda, Yutaro; Matsui, Daisuke; Hashiguchi, Kanae; Koyama, Teruhide; Iwai, Komei; Watanabe, Ichiro; Tanaka, Rika; Omichi, Chie; Mizuno, Shigeto; Kurokawa, Masao; Horii, Motoyuki; Niwa, Fumitoshi; Iwasa, Kinuko; Yamada, Shinsuke; Watanabe, Yoshiyuki

doi:10.1016/j.archger.2017.02.005

Cited by 30 publications

(26 citation statements)

References 45 publications

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“…The current literature on the association between selfreported sleep duration and BMD in men is mixed. Some studies found that both long [16,[25][26][27]30] and short [12,15,16,20,23] sleep duration are associated with low BMD; however, some studies did not show any association [11,13,29]. The lack of a significant association between BMD and sleep duration in older men in the current study is similar to findings from three prior studies in middle-aged and older men.…”

Section: Discussionsupporting

confidence: 84%

“…Human data are limited to mostly cross-sectional studies showing no association [11,12] or that both short [13][14][15][16][17][18][19][20][21][22][23] and long [13][14][15][16][17][24][25][26][27][28][29][30] sleep durations are associated with low BMD (as reviewed in [31]). Of the 20 studies published to date on the association between sleep duration and BMD in humans [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], women comprised the majority of participants. All studies of men used subjective (self-reported) sleep duration and focused primarily on middle-aged adults when it is older men who are at highest risk of bone loss and fracture, and potential effect modifiers, such as vitamin D status, were not considered.…”

Section: Introductionmentioning

confidence: 99%

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Sleep duration and bone health measures in older men

et al. 2020

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The associations between objective measures of sleep duration and bone outcomes in older men are unknown. No consistent, significant association was identified between sleep duration and bone mineral density (BMD) in the current analysis. However, future research should determine if vitamin D status modifies this relationship. Introduction Prior studies, predominantly in women, reported that long and short self-reported sleep duration are associated with lower BMD. Associations between actigraphy-determined sleep duration and BMD or bone turnover markers (BTMs) in older men are unknown. Methods Men in The Osteoporotic Fractures in Men (MrOS) Study with wrist actigraphy and concurrent BMD assessment but without comorbidities affecting bone health were included. Sleep duration was considered as a continuous (N = 1926) and dichotomized variable where men were classified as getting the recommended (7-8 h/night; N = 478) or short (< 6 h/night; N = 577) sleep. The cross-sectional association between BMD, BTMs, and sleep duration was examined using a t test or linear regression, where appropriate, in unadjusted and adjusted models. Results There were no clinically or statistically significant differences in BMD at the L-spine, total hip, or femoral neck between men getting the recommended vs. short sleep duration, using actigraphy or self-reported sleep duration (all p ≥ 0.07). When sleep duration was considered as a continuous variable, femoral neck BMD was higher in men with longer self-reported sleep duration (β = 0.006 ±0.003, p = 0.02), but this was not significant after further adjustment. In men with low 25OHD (< 20 ng/mL), longer actigraphy-determined sleep duration was associated with higher total hip BMD (β = 0.016 ± 0.008; p = 0.04). Sleep duration and BTMs were not associated.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Sleep duration and bone health measures in older men

et al. 2020

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“…Future studies may use more objective measures of sleep, such as waist‐wearing actigraphy device to improve quality of sleep data, and should include the additional consideration of bone microarchitecture. While the mechanisms for the association of sleep duration and BMD are not known, inadequate sleep duration is thought to impact hormone levels, sympathetic activation, inflammatory processes, and involve metabolic derangement. In a meta‐analysis, short sleep duration was associated with higher levels of C‐reactive protein, supporting a role of inflammation .…”

Section: Discussionmentioning

confidence: 99%

Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative

Ochs‐Balcom

Hovey

Andrews

et al. 2019

Journal of Bone and Mineral Research

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Short sleep duration, recognized as a public health epidemic, is associated with adverse health conditions, yet little is known about the association between sleep and bone health. We tested the associations of usual sleep behavior and bone mineral density (BMD) and osteoporosis. In a sample of 11,084 postmenopausal women from the Women's Health Initiative (WHI; mean age 63.3 years, SD = 7.4), we performed a cross-sectional study of the association of self-reported usual hours of sleep and sleep quality (WHI Insomnia Rating Score) with whole body, total hip, femoral neck, and spine BMD using linear regression models. We also studied the association of sleep duration and quality with dual-energy X-ray absorptiometry (DXA)-defined low bone mass (T-score < −2.5 to <−1) and osteoporosis (T-score ≤ −2.5) using multinomial regression models. We adjusted for age, DXA machine, race, menopausal symptoms, education, smoking, physical activity, body mass index, alcohol use, physical function, and sleep medication use. In adjusted linear regression models, women who reported sleeping 5 hours or less per night had on average 0.012 to 0.018 g/cm 2 significantly lower BMD at all four sites compared with women who reported sleeping 7 hours per night (reference). In adjusted multinomial models, women reporting 5 hours or less per night had higher odds of low bone mass and osteoporosis of the hip (odds ratio [OR] = 1.22; 95% confidence interval [CI] 1.03-1.45, and 1.63; 1.15-2.31, respectively). We observed a similar pattern for spine BMD, where women with 5 hours or less per night had higher odds of osteoporosis (adjusted OR = 1.28; 95% CI 1.02-1.60). Associations of sleep quality and DXA BMD failed to reach statistical significance. Short sleep duration was associated with lower BMD and higher risk of osteoporosis. Longitudinal studies are needed to confirm the cross-sectional effects of sleep duration on bone health and explore associated mechanisms. ResultsWith a mean age of 63.3 years (SD = 7.4), our postmenopausal sample is 78% non-Hispanic white. Approximately 10% of our sample reported sleeping 5 hours or less per night, and 4.5%Journal of Bone and Mineral Research n 262 OCHS-BALCOM ET AL.Model 1 adjusted for DXA serial number, age, menopausal symptoms, and race. Model 2 adjusted for model 1 plus education, smoking, physical activity, body mass index, alcohol use, physical function score, and sleep medication use.

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“…Ultrasonic measurements of the non-dominant side of the 5.5% distal radius were performed by use of a newly introduced QUS device, the LD-100 system, which allows determination of the trabecular bone density (TrBMD), and cortical thickness (CoTh) 17 – 19 . Results obtained with that device have been validated by a significant correlation with values obtained with Stratec pQCT 17 .…”

Section: Methodsmentioning

confidence: 99%

“…The transducers move simultaneously for scanning, with one transmitting ultrasound waves through the objective region and the other receiving those ultrasonic signals. TrBMD is estimated by quantifying the attenuation of the ultrasound waves transmitted through bone and transmission velocity of the fast wave propagated through trabecular bone structures, respectively 15 , 19 . CoTh, which is expressed in millimeters, was estimated by analyzing the reflected and transmitted ultrasonic signals, as previously described 18 , 20 , though it is not possible to apply echo measurements to cortical thickness.…”

Section: Methodsmentioning

confidence: 99%

Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus

Nakamura

Inaba

Yamada

et al. 2018

Sci Rep

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LD-100, a quantitative ultrasonic device, allows us to measure cortical thickness (CoTh). Patients with type 2 diabetes mellitus (T2DM) show high prevalence of sarcopenia. This study aimed to clarify the association of handgrip strength (HGS) with cortical porosis, a major risk for fracture of DM. CoTh and trabecular bone mineral density (TrBMD) at the 5.5% distal radius were assessed in T2DM female patients (n = 122) and non-DM female controls (n = 704) by LD-100. T2DM patients aged older 40 years showed significantly lower HGS and CoTh, but not TrBMD, than non-DM counterparts. Although HGS was significantly and positively correlated with CoTh and TrBMD in T2DM patients, multivariate analysis revealed HGS as an independent factor positively associated with CoTh, but not TrBMD, in T2DM patients, suggesting the preferential association of HGS with cortical, but not trabecular, bone component in T2DM female patients. In conclusion, the present study demonstrated an early decline of HGS in T2DM female patients as compared with non-DM healthy controls after the age of 40 years, which is independently associated with thinner CoTh, but not TrBMD in T2DM patients, and thus suggested that reduced muscle strength associated with DM might be a major factor for cortical porosis development in DM patients.

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Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity

Cited by 30 publications

References 45 publications

Sleep duration and bone health measures in older men

Sleep duration and bone health measures in older men

Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative

Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus

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