Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative

Ochs‐Balcom, Heather M.; Hovey, Kathleen M.; Andrews, Chris; Cauley, Jane A.; Hale, Lauren; Li, Wenjun; Bea, Jennifer W.; Sarto, Gloria E.; Stefanick, Marcia L.; Stone, Katie L.; Watts, Nelson B.; Zaslavsky, Oleg; Wactawski‐Wende, Jean

doi:10.1002/jbmr.3879

Cited by 55 publications

(44 citation statements)

References 33 publications

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“…However, other authors emphasize that both short and long sleep time in middle aged persons and elderly people is associated with signi cantly increased risk of osteoporosis, and an appropriate sleep time may help in delaying or preventing osteoporosis [33,34]. However, discussions on the appropriate length of sleep in people with osteoporosis are still ongoing.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Górczewska

Jakubowska-Pietkiewicz²

2020

Preprint

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BackgroundOsteoporosis is a social disease and epidemic of the 21st century, and is also a growing problem in the ageing Polish society. The aim of the study was to assess the quality of life (QoL) in women with postmenopausal osteoporosis. MethodsThe study was an outpatient, questionnaire-based poll, carried out from VI.2018 to V.2019. A group of 198 women, aged 72.31±8.59 years with diagnosed postmenopausal osteoporosis in two Osteoporosis Clinics in the city of Łódź (Poland) were included. The paper uses: the Polish version of the QUALEFFO 41 quality of life scale, the VAS scale and a survey of my own authorship. The data were analysed using multiple linear regression.ResultsThe average result of QUALEFFO-41 was 40.26±16.92 points. Analysing individual QUALEFFO-41 domains the lowest quality of life was found in the mental function domain (mental function 48.49±18.06 points). The visual analogue scale of pain was 4.87±2.39 points. The VAS scale positively correlated with all QUALEFFO 41 domains. Marital status, education and financial situation had a significant statistical impact on the quality of life (p<;0.05). Multiple regression step-by-step analysis showed that pain expressed on the VAS scale, pain awakening from sleep, taking sleeping pills and older age of respondents deteriorate the quality of life.ConclusionThe analysis showed that Polish women with postmenopausal osteoporosis have an average quality of life. In Poland the assessment of quality of life of chronically ill patients and routine evaluation of pain severity on the VAS scale is not common.

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Section: Discussionmentioning

confidence: 99%

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Górczewska

Jakubowska-Pietkiewicz²

2020

Preprint

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“…We have not shown a statistically signi cant relationship between sleep length and QUALEFFO 41. The literature (2020) describes that short sleep time (less or equal to 5 h) was associated with lower BMD and higher risk of osteoporosis [32]. Ochs-Balcom HM et al in a group of 11 084 postmenopausal women observed that short sleep time (less than or equal to 5 h) was associated with lower BMD and higher risk of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in The Łódź Province

Górczewska¹,

Jakubowska-Pietkiewicz²

2020

Preprint

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Osteoporosis is a social disease and epidemic of the 21st century, and is also a growing problem in the ageing Polish society. The aim of the study was to assess the quality of life (QoL) in women with postmenopausal osteoporosis. Material and methods The study was an outpatient, questionnaire-based poll, carried out from VI.2018 to V.2019. A group of 198 women, aged 72.31±8.59 years with diagnosed postmenopausal osteoporosis in two Osteoporosis Clinics in the city of Łódź (Poland) were included. The paper uses: the Polish version of the QUALEFFO 41 quality of life scale, the VAS scale and a survey of my own authorship. The data were analysed using multiple linear regression.Results The average result of QUALEFFO-41 was 40.26±16.92 points. Analysing individual QUALEFFO-41 domains the lowest quality of life was found in the mental function domain (mental function 48.49±18.06 points). The visual analogue scale of pain was 4.87±2.39 points. The VAS scale positively correlated with all QUALEFFO 41 domains. Marital status, education and financial situation had a significant statistical impact on the quality of life (p<;0.05). Multiple regression step-by-step analysis showed that pain expressed on the VAS scale, pain awakening from sleep, taking sleeping pills and older age of respondents deteriorate the quality of life.Conclusion The analysis showed that Polish women with postmenopausal osteoporosis have an average quality of life. In Poland the assessment of quality of life of chronically ill patients and routine evaluation of pain severity on the VAS scale is not common.

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“…Lower melatonin levels due to reduced light exposure may lead to fewer interactions between estrogen and its receptors and, thus, negatively impact BMD [ 79 ]. However, other studies report either positive or null relationships between sleep duration and BMD in postmenopausal women [ 80 , 81 , 82 , 83 ]. The conflicting evidence in this area may be due to confounding study participant factors that are not uniformly controlled for across the studies, such as age, body composition, diet, and nighttime-only sleep duration versus inclusion of daytime naps.…”

Section: Postmenopausal Osteoporosis: a Silent Diseasementioning

confidence: 99%

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

Walallawita

Wolber

Ziv‐Gal

et al. 2020

IJMS

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Osteoporosis is a metabolic bone disease characterized by reduced bone mineral density, which affects the quality of life of the aging population. Furthermore, disruption of bone microarchitecture and the alteration of non-collagenous protein in bones lead to higher fracture risk. This is most common in postmenopausal women. Certain medications are being used for the treatment of osteoporosis; however, these may be accompanied by undesirable side effects. Phytochemicals from fruits and vegetables are a source of micronutrients for the maintenance of bone health. Among them, lycopene has recently been shown to have a potential protective effect against bone loss. Lycopene is a lipid-soluble carotenoid that exists in both all-trans and cis-configurations in nature. Tomato and tomato products are rich sources of lycopene. Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. However, there are still limited studies that have evaluated the effect of lycopene on the prevention of bone loss in postmenopausal women. Therefore, the aim of this review is to summarize the relevant literature on the potential impact of lycopene on postmenopausal bone loss with molecular and clinical evidence, including an overview of bone biology and the pathophysiology of osteoporosis.

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Short Sleep Is Associated With Low Bone Mineral Density and Osteoporosis in the Women's Health Initiative

Cited by 55 publications

References 33 publications

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in the Łódź Province

Quality of Life in Women With Postmenopausal Osteoporosis - Pilot Studies in The Łódź Province

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

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