Association between Lipid Profiles and Renal Functions among Adults with Type 2 Diabetes

Abstract

<b><i>Introduction:</i></b> Type 2 diabetes mellitus (T2DM) affects renal functions and lipid profiles of patients. <b><i>Objectives:</i></b> In this study, 100 patients (65 females, 35 males) with T2DM were evaluated to determine whether renal function characteristics and lipid profiles are associated with T2DM. <b><i>Methods:</i></b> Blood samples were collected from all patients with T2DM, and the levels of hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>), blood urea, serum creatinine, cholesterol, triglyceride (TGR), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL) were analyzed. <b><i>Results:</i></b> A direct correlation of blood sugar and HbA<sub>1c</sub> was observed with blood urea, serum creatinine, serum cholesterol, serum TGR, HDL, LDL, and VLDL. The results revealed elevated TGR levels in patients administered medications for hyperglycemia. Furthermore, serum TGR levels were significantly correlated with blood sugar levels (<i>p</i> = 0.035). Blood urea levels were significantly correlated with glycated hemoglobin (<i>p</i> = 0.008). Blood urea, serum creatinine, and serum cholesterol levels were highly significantly correlated with HbA<sub>1c</sub> (<i>p</i> = 0.008, 0.017, and 0.005, respectively), while HDL, LDL, and VLDL were not significantly correlated with HbA<sub>1c</sub>. <b><i>Conclusion:</i></b> This study highlights the importance of serum TGR and serum creatinine measurement for guiding the treatment of T2DM.

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“…Hyperlipidemia induced by diabetes is in turn cause excess mobilization of fat from the adipose tissues because of the underutilization of glucose. Increased levels of fatty acids due to high levels of TGRs (triglycerides), LDL and low levels of HDL in turnarouse insulin resistance as well as dysfunctioning of β-cells (Hamzah, 2019). We have observed high levels of TC, LDL and TG's in negative control group although our C.viminalis and A. rosea 200, 400mg/kg/day animals showed significant reduction in TC, LDL, TG's and raised values of HDL.…”

Role of Vernonia Amygdalina on Plasma Lipid Profile, Liver and Kidney Enzymes in Rats with Streptozotocin-Induced Diabetes

“…Type 1, insulin-dependent diabetes mellitus (T1DM) and type 2, non-insulin-independent diabetes mellitus (T2DM) are the two main types of DM. T2DM occurs majorly in adults that is about 40 years old and above and is caused by a deficiency of insulin or its secretion [5]. Lifestyle factors such as unhealthy diet and lack of physical activity or exercise that may result in excess body weight and abdominal obesity, and also genetic factors are known causes of T2DM [1,6].…”