Association between leptin, obesity, hormonal interplay and male infertility

Amjad, Sofia; Baig, Mukhtiar; Zahid, Nida; Tariq, Sundus; Rehman, Rehana

doi:10.1111/and.13147

Cited by 44 publications

(35 citation statements)

References 32 publications

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“…Obesity is one of the common causes of reduced androgen in ageing men with hypogonadism 20 32. While it is clear that the measurement of WC is reliable in the evaluation of visceral fat distribution, other underlying pathogenesis factors of LAP-associated LOH could be the secreted adipocytokines and inflammatory factors from visceral fat mass 33 34.…”

Section: Discussionmentioning

confidence: 99%

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

et al. 2020

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ObjectivesHypogonadism in men is related to the deterioration of general health. However, the association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed to provide an insight into the possible links between the lipid accumulation product (LAP) and late-onset hypogonadism (LOH).SettingSun Yat-sen Memorial Hospital of Sun Yat-sen University.ParticipantsWe included a population sample of 997 subjects aged 40 years or older.Primary and secondary outcome measuresThe LAP was calculated by gender-specific equations using waist circumference (WC) and triglyceride (TG). LOH was defined by the presence of androgen deficiency symptoms and low serum total testosterone levels.ResultsThe prevalence of LOH was 9.4% in this population and gradually increased according to increasing LAP quartiles. Compared with subjects without LOH, ageing men with LOH had higher body mass index, WC, systolic blood pressure, percentage of subjects currently smoking, TG and follicle stimulating hormone and lower low-density lipoprotein cholesterol and sex hormone binding globulin. In multivariate logistic regression analysis, the adjusted ORs of LOH for increasing LAP quartiles 1–4 were 1.00 (reference), 1.10 (95% CI 0.45–2.69), 2.15 (95% CI 0.93–4.94) and 3.83 (95% CI 1.73–8.45), respectively.ConclusionBody lipid accumulation evaluated by the LAP is independently associated with the prevalence of LOH in middle-aged and elderly Chinese men.

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Section: Discussionmentioning

confidence: 99%

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

et al. 2020

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“…Obesity has since been linked to infertility in couples globally; male obesity accounts for 20%‐70% of the problems and is clearly associated with several adverse reproductive outcomes 3 . There is evidence of disturbances in the hypothalamic‐pituitary‐gonadal (HPG) axis that eventually affect testosterone and oestrogen levels 4 .…”

Section: Introductionmentioning

confidence: 99%

Orlistat attenuates obesity‐induced decline in steroidogenesis and spermatogenesis by up‐regulating steroidogenic genes

et al. 2020

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Background Steroidogenesis decline is reported to be one of the mechanisms associated with obesity‐induced male factor subfertility/infertility. Objectives We explored the possible preventive/therapeutic effects of orlistat (a medication prescribed for weight loss) on obesity‐induced steroidogenesis and spermatogenesis decline. Materials and methods Twenty‐four adult male Sprague Dawley rats weighing 250‐300 g were randomized into four groups (n = 6/group), namely; normal control, high‐fat diet, high‐fat diet plus orlistat preventive group and high‐fat diet plus orlistat treatment group. Orlistat (10 mg/kg/b.w./d suspended in distilled water) was either concurrently administered with high‐fat diet for 12 weeks (high‐fat diet plus orlistat preventive group) or administered from week 7‐12 post‐ high‐fat diet feeding (high‐fat diet plus orlistat treatment group). Thereafter, serum, testes and epididymis were collected for analyses. Results Obesity increased serum leptin and decreased adiponectin levels, decreased serum and intra‐testicular levels of follicle stimulating hormone, luteinising hormone and testosterone, sperm count, motility, viability, normal morphology and epididymal antioxidants, but increased epididymal malondialdehyde level and sperm nDNA fragmentation. Testicular mRNA transcript levels of androgen receptor, luteinizing hormone receptor, steroidogenic acute regulatory protein, cytochrome P450 enzyme (CYP11A1), 3β‐hydroxysteroid dehydrogenase and 17β‐hydroxysteroid dehydrogenase were significantly decreased in the testes of the high‐fat diet group. Further, the levels of steroidogenic acute regulatory protein protein and enzymatic activities of CYP11A1, 3β‐hydroxysteroid dehydrogenase and 17β‐hydroxysteroid dehydrogenase were also significantly decreased in the testes of the high‐fat diet group. Treatment with orlistat significantly decreased leptin and increased adiponectin levels, improved sperm parameters, decreased sperm DNA fragmentation, increased the levels of steroidogenic hormones, proteins and associated genes in high‐fat diet‐induced obese male rats, with the preventive group (high‐fat diet plus orlistat preventive group) having better results relative to the treatment group (high‐fat diet plus orlistat treatment group). Discussion and Conclusion Orlistat attenuated impaired spermatogenesis and steroidogenesis decline by up‐regulating steroidogenic genes. This may not be unconnected to its significant effect in lowering serum leptin levels, since the hormone is known to dampen fertility potential. Therefore, orlistat may improve fertility potential in overweight/obese men.

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“…8 Abnormal semen characteristics can be caused by a variety of factors, including low sperm production and/or poor sperm quality. 9 Currently, oxidative stress )OS( has been identified as a potential cause of idiopathic male infertility, which has detrimental effect on semen quality and fertility. 10,11 Oxidative stress is the disturbance in the balance within the generation of the oxidants and the ability of antioxidant defenses to neutralize their harmful effects.…”

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confidence: 99%

Effect of seminal redox status on lipid peroxidation, apoptosis and DNA fragmentation in spermatozoa of infertile Saudi males

Fatima

Alwaznah

Aljuraiban

et al. 2020

SMJ

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To assess the effect of seminal redox status on lipid peroxidation)LPO(, apoptosis and integrity of sperm DNA in infertile males. Methods: In this case-control study, the total antioxidant status)TAS(and reactive oxygen species)ROS(levels were analyzed within the seminal plasma of fertile normozoospermic, n=40 and infertile)asthenozoospermic, n=30; oligoasthenoteratozoospermic, n=30(males. Additionally, the level of 4-hydroxynonenal)4-HNE(, DNA fragmentation, and caspase-3 activity were estimated in the spermatozoa. Original Article Results: Significantly)p<0.001(increased seminal ROS level with decreased TAS scores was observed in the infertile groups compared to normozoospermics. The infertile males showed marked elevated)p<0.001(levels of 4-HNE, DNA fragmentation and caspase-3 activity compared to normozoospermics, which was positively correlated to increased seminal ROS levels and negatively to the TAS score in the studied groups. Seminal ROS level was significantly inverse correlated to the semen parameters. Additionally, a strong negative correlation between DNA fragmentation, LPO, caspase-3activity and seminal parameters were observed. Conclusion: Seminal oxidative stress is a potential risk factor for LPO, DNA damage, and apoptosis in spermatozoa, which can affect semen quality and male fertility. Thus, in addition to conventional seminological parameters, measurement of seminal oxidative stress and sperm DNA integrity may also be employed to investigate the functional integrity of spermatozoa at the molecular level.

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Association between leptin, obesity, hormonal interplay and male infertility

Cited by 44 publications

References 32 publications

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

Orlistat attenuates obesity‐induced decline in steroidogenesis and spermatogenesis by up‐regulating steroidogenic genes

Effect of seminal redox status on lipid peroxidation, apoptosis and DNA fragmentation in spermatozoa of infertile Saudi males

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