Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

Sun, Kan; Wang, Chengzhi; Lao, Guojuan; Lin, Diaozhu; Li, Na; Li, Fangping; Xiao, Huisheng; Yan, Li

doi:10.1136/bmjopen-2019-033991

Cited by 7 publications

(10 citation statements)

References 40 publications

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“…It is known that an increase in the concentration of insulin in obesity causes a rise in the concentration of triglycerides and low-density lipoproteins, and a decrease in the level of high density lipoproteins [10]. Our study has found a direct relationship between BMI and triglyceride and LDL levels, and an inverse relationship with HDL levels [25].…”

Section: Discussionsupporting

confidence: 59%

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Effect of SHBG Polymorphism on the Levels of Bioavailable Testosterone and Lipid Metabolism in Older Men of the Kazakh Population

Akkaliyev

Aukenov²,

Massabayeva

et al. 2022

Open Access Maced J Med Sci

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This study is aimed at investigating the effect of SHBG (rs727428; rs10822184) and LPL (rs754493647) single nucleotide polymorphisms on the concentration of the bioavailable fraction of testosterone in older men. Materials and methods To study gene mutations, 417 residents of the East Kazakhstan region of Kazakh nationality were examined. The main group included 135 men with signs of hypogonadism (AMS 37-49), and the control group consisted of 282 healthy men (AMS 17-26) of the corresponding age (p = 0.5). Single nucleotide polymorphisms rs 727428 [C / T]; rs10822184 [T / C]; rs754493647 [T / C], was determined by the TaqMan method. Results Analysis of the rs727428 polymorphism has revealed that the TT allele (rs727428) has a lower level of albumin (p = 0.03), bioavailable testosterone (p = 0.04), and free testosterone (p = 0.6) than in carriers of the CC and CT genotypes. Also, it has shown a decrease in total testosterone (p = 0.001) and an increase in SHBG levels (p = 0.07) in men with the TT genotype of the rs727428 gene polymorphism. The rs10822184 polymorphism demonstrated an increase in triglyceride and LDL levels in TT genotype (p ≤ 0.04), in comparison with CC and CT genotypes. Conclusion It has been proven that rs727428 (p = 0.001) is associated with testosterone levels and therefore can determine the concentration of bioavailable testosterone. Decreased levels of bioavailable testosterone are a sign of male hypogonadism. This study confirms the effect of rs10822184 on LDL (p = 0.01) and triglyceride (p = 0.04) levels, but its association with androgen levels has not been proven. Our results may be of interest for understanding the etiology of early development of hypogonadism and lipid metabolism disorders in men. To confirm the conclusions, a more detailed study with a large sample of men from the Kazakh population may be required.

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Section: Discussionsupporting

confidence: 59%

“…A group of 135 patients with signs of AMS hypogonadism (37-50) and 282 men from the control group of AMS men (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) were involved in the study.…”

Section: Resultsmentioning

confidence: 99%

Effect of SHBG Polymorphism on the Levels of Bioavailable Testosterone and Lipid Metabolism in Older Men of the Kazakh Population

Akkaliyev

Aukenov²,

Massabayeva

et al. 2022

Open Access Maced J Med Sci

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“…LAP are important indicators for the diagnosis of visceral obesity and are more sensitive than BMI indicators. In obese and adipose older men with non‐diabetes, LAP, a central obesity marker, is also thought to be associated with IR and diabetes, and with late‐onset hypogonadism in older Chinese men 26 . In the current study, in terms of predictive power, LAP was second only to HOMA‐IR with an AUC of 0.718 in non‐diabetic patients.…”

Section: Discussionmentioning

confidence: 50%

“…Other studies in post‐menopausal women found that LAP was a cardiovascular risk factor and was adversely linked with sex hormone‐binding globulin and HDL‐C 29 . In middle‐aged and older men, the Chinese investigation discovered an independent relationship between LAP and late‐onset hypogonadism 26 …”

Section: Discussionmentioning

confidence: 95%

Association of lipid accumulation products with testosterone deficiency in adult American men: A cross‐sectional study

et al. 2022

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Purpose: Testosterone deficiency and changes in testosterone levels are important in men's health and may be associated with fat accumulation. In order to investigate the connection between testosterone and fat accumulation in adult males, we employed lipid accumulation product and compared it to triglyceride-glucose and Homeostasis Model Assessment of Insulin Resistance. Materials and methods:An intersecting surface research of participators from 2013 to 2014 was carried out using National Health and Nutrition Examination Survey, in addition, participants from 2015 to 2016 were selected. Using multivariate adjusted logistic regression, the connection between lipid accumulation product, testosterone levels, and testosterone insufficiency was investigated, smoothed curve fitting was calculated to integrate non-linear relationships, and subgroup analysis was performed to identify sensitive populations.Results: After removing all potential confounders, testosterone levels in 1651 subjects tended to decrease with increasing continuous variable lipid accumulation product (β = -0.49, 95% confidence interval [-0.77, -0.22], p = 0.0005) and adding the chance of testosterone deficiency (odds ratio = 1.01, 95% confidence interval [1.01, 1.01], p < 0.0001). In the lipid accumulation product quartile, testosterone levels decreased the most (β = -77.65, 95% confidence interval [-110.99, -44.31], p < 0.0001) and the risk of testosterone deficiency was highest (odds ratio = 2.76, 95% confidence interval [1.47, 5.20], p = 0.0016). The area under the curve values were 0.718 (95% confidence interval: 0.688-0.750) for lipid accumulation product, 0.723 (95% confidence interval: 0.689-0.756) for Homeostasis Model Assessment of Insulin Resistance, and 0.673 (95% confidence interval: 0.640-0.708) for triglyceride-glucose, with no statistical difference between lipid accumulation product and Homeostasis Model Assessment of Insulin Resistance comparisons. The cut-off value of lipid accumulation product ≥52.408 predicted testosterone deficiency with good sensitivity and specificity.

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“…Several studies have shown that visceral obesity in men is associated with low testosterone levels, male infertility, and erectile dysfunction [ 24 – 28 ]. In animal experiments, weight loss was associated with a rise in testosterone, free testosterone (FT) and sex hormone-binding globulin (SHBG), whereas weight gain was associated with a fall in these levels [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men

et al. 2022

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Background Aging-related hypogonadism in men is related to the deterioration of overall health. Those with this disease rarely receive treatment. The hypertriglyceridemic waist (HTGW) phenotype is a tool for predicting abnormalities of cardiovascular metabolism. However, the relationship between the HTGW phenotype and hypogonadism remains undetermined. This study aimed to determine the association between HTGW phenotype and hypogonadism in different age groups. Methods Data of this cross-sectional study were obtained from MJ Health Screening Center in Taiwan from 2007 to 2016. The HTGW phenotype was divided into four categories based on whether the waist circumference (WC) and triglyceride levels were normal. WC of <90 cm and triglyceride level of <150 mg/dL were defined as normal. Hypogonadism was defined as a testosterone level of <300 ng/dL. Results Overall, 6442 male participants were divided into three age groups: <50, 50–64, and ≥65 years (n = 4135, 1958, and 349; age groups 1, 2, and 3, respectively). The overall prevalence of hypogonadism was 10.6%. In group 1, participants with HTGW (odds ratio, 1.98; 95% confidence interval (CI), 1.354–2.896) had a higher risk of hypogonadism than those with normal WC and normal triglyceride levels after adjustment for body mass index and fasting blood glucose level. In group 2, participants with HTGW (odds ratio, 1.873; 95% CI, 1.099–3.193) had an increased risk of hypogonadism after adjustment for body mass index, fasting blood glucose level, Cholesterol levels, high-density lipoprotein (HDL) levels, low-density lipoprptein (LDL) levels and smoking status. However, no relationship was observed between HTGW phenotype and hypogonadism in group 3. Conclusion HTGW phenotype was highly associated with hypogonadism in Taiwanese adult men. More attention should be paid to men aged <50 years with HTGW.

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Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China

Cited by 7 publications

References 40 publications

Effect of SHBG Polymorphism on the Levels of Bioavailable Testosterone and Lipid Metabolism in Older Men of the Kazakh Population

Effect of SHBG Polymorphism on the Levels of Bioavailable Testosterone and Lipid Metabolism in Older Men of the Kazakh Population

Association of lipid accumulation products with testosterone deficiency in adult American men: A cross‐sectional study

Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men

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