Association between LDL particle size and postprandial increase of remnant-like particles in Japanese type 2 diabetic patients

Factors influencing the formation of small dense low-density lipoprotein particles in dependence on the presence of the metabolic syndrome and on the degree of glucose intolerance

“…This result is in correspondence with other publications (28)(29)(30)(31). In the literature there are papers (32)(33)(34)(35) pointing to the fact that postprandial increases of large VLDL fractions and remnant-like particles contribute to the formation of small dense LDL in coronary heart disease patients.…”

Hepatic fat content is a determinant of postprandial triglyceride levels in type 2 diabetes mellitus patients with normal fasting triglyceride

“…The elevated postprandial TG levels are also observed in subjects with metabolic syndrome who have no history of diabetes [5]. The pathogenesis of postprandial TG-induced atherosclerosis is unclear but may be associated with the development of oxidative stress and endothelial dysfunction [6][7][8]. Several studies have demonstrated the strong association between visceral adipose tissue (VAT) and postprandial TG levels in both nondiabetic and T2D subjects [9][10][11].…”

Usefulness of aggressive lipid-lowering therapy with rosuvastatin in hypercholesterolemic patients with concomitant type 2 diabetes

“…Type 2 diabetes is characterized by concomitant hypertriglyceridemia (TG) and hypo-HDL cholesterolemia (-C), though the frequency of simultaneous hyper-LDL-C is not low. In addition, type 2 diabetes is characterized by the fact that even if the LDL-C level is not high, glycosylated LDL and small dense LDL increase due to qualitative changes in glycosylated or miniaturized LDL particles, with simultaneous increase in remnant-like lipoprotein particles (RLP) [10][11][12][13]. The recommendations for primary prevention of cardiovascular diseases in patients with diabetes by the American Diabetes Association and the American Heart Association (2007) [14] indicate that because LDL particle size in diabetic patients is small and that these particles are of high density, diabetic patients are at high risk for the development of coronary artery disease if they have the same LDL-C level.…”