Association Between Later Life Lifestyle Factors and Alzheimer’s Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study

Reijs, Babette L.R.; Vos, Stephanie J.B.; Lötjönen, Jyrki; Koikkalainen, Juha; Pikkarainen, Maria; Hall, Anette; Vanninen, Ritva; Liu, Yawu; Herukka, Sanna Kaisa; Freund‐Levi, Yvonne; Frisoni, Giovanni B.; Frölich, Lutz; Nobili, Flavio; Rikkert, Marcel G M Olde; Spiru, Luiza; Tsolaki, Magda; Wallin, Åsa; Scheltens, Philip; Verhey, Frans R.J.; Visser, Pieter Jelle

doi:10.3233/jad-170039

Cited by 24 publications

(32 citation statements)

References 42 publications

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“…One study showed that higher education or vocabulary scores may delay clinical onset of dementia in people with MCI 11 . Another three studies suggested that that later life social or cognitive activities, 12 intellectual social activities, 10 and education 13 were not associated with the conversion from MCI to dementia. In addition, occupational attainment 40 and measurement of intelligence quotient 41 were risk factors for a higher rate of progression from MCI to Alzheimer's dementia.…”

Section: Discussionmentioning

confidence: 99%

“…One study has indicated that high education might delay the onset of dementia in people with MCI 11 . Others found that social or cognitive activities 10,12 and education 13 were not associated with the conversion from MCI to dementia. According to the theory of CR, although greater CR could compensate for pathology at the onset of cognitive decline, once the reserve has reached the amount of pathology that can be compensated for, a more rapid rate of decline might be evident 1 .…”

Section: Introductionmentioning

confidence: 99%

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Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Yang

Dintica

et al. 2020

Alzheimer's & Dementia

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Introduction The association of lifespan cognitive reserve (CR) with mild cognitive impairment (MCI) remains controversial. We aimed to examine the association of lifespan CR indicator with the risk of MCI and its progression to dementia, taking brain pathologies into account. Methods In a community‐based cohort study (mean age, 79 years) with annual follow‐up (median, 5.16 years; maximum, 20 years), a cognitively intact group (n = 1182) and an MCI group (n = 420) were identified at baseline. During the follow‐up, 611 participants died and underwent autopsies. CR indicator encompassing education, early life to late‐life cognitive and social activities were obtained and tertiled. Results The multi‐adjusted hazard ratio (HR) of MCI was 0.72 (95% confidence interval [CI] 0.58 to 0.90) in the cognitively intact group, and the HR of dementia was 0.66 (95% CI 0.45 to 0.97) in the MCI group for participants with the highest CR indicator (reference: the lowest CR indicator). Among MCI participants with brain pathologies, dementia incidence was about 50% lower in people with the highest CR indicator than the lowest CR indicator. Discussion High lifespan CR indicator reduces risk of MCI, and delays its progression to dementia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Yang

Dintica

et al. 2020

Alzheimer's & Dementia

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“…A longitudinal descriptive cohort study demonstrated did not find a significant association between Alzheimer's disease biomarkers and a cluster of lifestyle factors (i.e. social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep) in non‐demented individuals 32 . However, this study also did not consider the combined effects of these lifestyle factors.…”

Section: Discussionmentioning

confidence: 59%

“…social activity, physical activity, cognitive activity, smoking, alcohol consumption, and sleep) in non-demented individuals. 32 However, this study also did not consider the combined effects of these lifestyle factors. Another population-based study of 1716 participants aged 65 years and older explored the combined effect of Mediterranean lifestyle factors on cognitive function based on a total lifestyle index that factored in diet, physical activity, sleep, and activities of daily living.…”

Section: Discussionmentioning

confidence: 97%

Combined effect of three common lifestyle factors on cognitive impairment among older Chinese adults: a community‐based, cross‐sectional survey

Qian

Ma²,

Sun

et al. 2020

Psychogeriatrics

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Aim: Lifestyle factors may influence cognitive function. Therefore, we compared the risk of cognitive impairment (COI) of all possible combinations of three lifestyle factors-tea consumption, physical activity, and siesta (afternoon nap or rest)-to the absence of any of these lifestyle factors. Methods: This cross-sectional study consisted of 4579 communitydwelling Chinese individuals aged 60 years or older living in Suzhou. Among the subjects were 3634 participants with normal cognition and 945 who had been diagnosed with COI according to the Abbreviated Mental Test. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with a multivariate-adjusted model by logistic regression. Results: Individually, tea consumption and physical activity significantly lowered the risk of COI to 0.66 (95%CI: 0.48-0.90) and 0.79 (95% CI: 0.65-0.96), respectively. In combination, physical activity and siesta reduced the risk of COI to the greatest extent (OR = 0.44, 95% CI: 0.31-0.64). Based on multivariate adjustment, almost all combinations of factors had a significant negative association with COI, but the combination of tea consumption and siesta had an irrelevant correlation with COI. All combinations of lifestyle factors had a lower OR than any single lifestyle factor among the correlations that were significant. Conclusion: Based on our findings, engaging in physical activity in combination with either or both of the other lifestyle factors was associated with a lower OR of having COI than adhering on a single factor in elderly Chinese people.

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“…not demented, [ 20 ] and diagnosis based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria. [ 21 ]…”

Section: Methodsmentioning

confidence: 99%

Effect of alcohol intake on the development of mild cognitive impairment into dementia

et al. 2020

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Association Between Later Life Lifestyle Factors and Alzheimer’s Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study

Abstract: Later life lifestyle factors had no impact on key AD biomarkers in individuals with SCD and MCI or on conversion to AD-type dementia in MCI.

Cited by 24 publications

References 42 publications

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia

Combined effect of three common lifestyle factors on cognitive impairment among older Chinese adults: a community‐based, cross‐sectional survey

Effect of alcohol intake on the development of mild cognitive impairment into dementia

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