Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population

Miao, Heng; Zhou, Xiaohui; Mei, Ting; Renner, Wilfried; Abulizi, Palida; Tang, Baopeng

doi:10.1007/s00508-012-0245-7

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Characteristics of the studies included for meta-analysis are shown in Table 1. Four [18,23,24,27] of these articles were published in Chinese and 10 [17,19–22,25,26,28–30] in English. The sample sizes ranged from 130 to 888 of all eligible studies.…”

Section: Resultsmentioning

confidence: 99%

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Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

Jiang

Chen²,

Zhang³

et al. 2017

Medicine

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Section: Resultsmentioning

confidence: 99%

“…Among the 14 studies, 8 of them [17,19,20,24–26,28,29] reported association between KCNE1 G38S polymorphism and risk of AF, whereas the other 6 studies [18,21–23,27,30] reported no significant association. So we conducted the present meta-analysis to evaluate the association between KCNE1 G38S polymorphism and AF.…”

Section: Introductionmentioning

confidence: 99%

Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

Jiang

Chen²,

Zhang³

et al. 2017

Medicine

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“…Although the exact mechanism by which the KCNE1 112G>A polymorphism contributes to the risk of AF remains poorly understood, a possible explanation may be that the 112G variant is likely associated with an increased I Ks current and high KCNQ1 membrane expression, which may be a genetic determinant of AF (Lai et al, 2002;Zeng et al, 2007;Haijun et al, 2012). KCNE1 is the founding member of the KCNE family of membrane proteins, which are considered to act as selective potassium channel modulators in regulating cellular electrophysiology (Takumi et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis

et al. 2014

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ABSTRACT. KCNE1, a membrane protein that spans the membrane once is responsible for modulating potassium channel functions and plays an important role in the etiology of arrhythmia. Emerging evidence indicates that a common polymorphism (112G>A; rs1805127 G>A) in the KCNE1 gene contributes to atrial fibrillation (AF) risk; however, these studies showed inconclusive results. In this meta-analysis, we derived a more precise estimation of the association between the KCNE1 112G>A polymorphism and AF risk. The following databases were searched: Web of Science (1945Science ( -2013, the Cochrane Library Database (Issue 12, 2013), PubMed (1966PubMed ( -2013, EMBASE (1980-2013), CINAHL (1982-2013, and the Chinese Biomedical Database (1982Database ( -2013. The crude odds ratios with their 95% confidence intervals were calculated. Nine case-control studies were included, with a total of 1792 AF patients and 1924 healthy controls. The meta-analysis results indicated that the KCNE1 112G variant is associated with an increased risk of AF. Further subgroup analysis based on ethnicity revealed significant associations between the KCNE1 112G variant and an increased risk of AF among both Asians and Caucasians. No publication bias was detected in this meta-analysis. In conclusion, our results indicate that the KCNE1 112G polymorphism may be a risk factor for AF. KCNE1 112G>A may be useful as a biomarker for predicting the development of AF.

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“…Recently, multiple population-based studies have provided evidence of a genetic contribution to AF ( 5 – 7 ). Mutations in the cardiac ion channel genes were found to play a role in the development of AF ( 8 – 13 ), but these mutations account for only a small fraction of patients with AF ( 14 , 15 ). Previous genome-wide association studies (GWAS) have indicated several significant candidate genes associated with this complex disorder, including genetic loci PITX2 on chromosome 4q25, ZFHX3 on chromosome 16q22, and KCNN3 on chromosome 1q21 ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population

Fang

Liu

et al. 2015

Anatol J Cardiol

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Objective:Previous genome-wide association studies (GWASs) have identified rs6817105—a single nucleotide polymorphism (SNP) on chromosome 4q25—to be associated with the risk of atrial fibrillation (AF) in a European-descent population. We recently demonstrated this association in a large cohort of Japanese ancestry. Our present study was designed to determine this association in the Chinese Han population.Methods:This case–control study included 597 AF cases and 996 AF-free controls, and rs6817105 SNPs were genotyped using the TaqMan allelic discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated in logistic regression models.Results:The genotype distribution of rs6817105-CC was significantly more frequent in the AF patients than in the controls (p=3.24´10-32). In our study, logistic regression analysis showed a strong association between rs6817105 and the risk of AF (additive model: OR=2.22, 95%CI=1.89–2.61, p=2.33´10-22; dominant model: OR=2.96, 95% CI: 2.16–4.07, p=2.03´10-11; recessive model: OR=2.83, 95%CI=2.27–3.54, p=4.00´10-20). Stratification analyses showed a borderline statistical difference between subgroups of age for the association of rs6817105 with AF risk (p=0.049). However, further interactive analysis indicated no significant interaction between genotype of rs6817105 and age (p=0.178).Conclusion:Our finding suggested that SNP rs6817105 may be associated with a high significant risk of AF in the Chinese Han population, although more replicative studies of larger sample size are needed to confirm this finding.

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Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population

Abstract: The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.

Cited by 4 publications

References 22 publications

Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

KCNE1 112G>A polymorphism and atrial fibrillation risk: a meta-analysis

The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population

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