Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

Jiang, Yufeng; Chen, Min; Zhang, Nannan; Yang, Hua-Jia; Xu, Lang-Biao; Qing, Rui; Sun, Si-Jia; Yao, Jialu; Zhou, Yafeng

doi:10.1097/md.0000000000007253

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…Numerous studies have investigated the role of the KCNE1 gene in AF. Jiang et al [17] conducted a metaanalysis of a total of 14 independent case-control studies involving 2,810 patients and 3,080 healthy controls. They concluded that the G38S polymorphism in the KCNE1 gene could significantly increase the risk of AF in both Chinese and Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of a shortened ERP within atrial cardiomyocytes might contribute to the development of multiple-circuit reentry that can predispose to a form of AF [15]. Polymorphism in the KCNE1 gene (G38S) increases the risk of AF significantly in both Chinese and Caucasian populations [17], suggesting the importance of KCNE1 gene in the predisposition to AF. It has also been reported that the minor allele of rs2236609 in KCNE1 trends toward significance with a longer QTc, which increases the risk of irregular heartbeat [18].…”

Section: Introductionmentioning

confidence: 99%

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The rs2236609 Polymorphism Is Related to Increased Risk Susceptibility of Atrial Fibrillation

Alzoughool

Atoum

Abu-Awad

et al. 2020

Public Health Genomics

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Introduction: Genetic variations in the slow component of the delayed rectifier potassium channels (I Ks ) are reported to contribute to an increased susceptibility to arrhythmias. This study aims to investigate the frequency and the possible association of the rs2236609 polymorphism in the KCNE1 gene and the risk of atrial fibrillation (AF). Methods: This was a case-control study that recruited 100 patients suffering from AF (mean age 49.4 ± 15.1 years), and a control group of 95 healthy participants older than 55 years (mean age 59.8 ± 4.1 years) with no history of cardiovascular disease, hypertension, or diabetes. Genomic DNA was extracted from whole peripheral blood, and the desired fragment was amplified using polymerase chain reaction followed by restriction digestion with the NspI restriction enzyme. Results: The results showed a significant difference between the single-nucleotide polymorphism variations in AF patients and controls (p < 0.022). The risk of AF in the GG genotype was significantly decreased (odds ratio [OR] 0.42; 95% confidence inter-val [Cl] 0.23-0.79). The risk of AF in the GA (OR 2.12; 95% Cl 1.11-4.06) and AA (OR 2.28, 95% Cl 0.57-9.1) genotypes was significantly increased. The odds of developing AF according to A allele counting was significantly increased (OR 2.1; 95% Cl 1.2608-3.638; p = 0.0048). Conclusion: Our results showed a significant increase in AF risk in people carrying the A allele, while the G allele might be considered as a protective allele.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The rs2236609 Polymorphism Is Related to Increased Risk Susceptibility of Atrial Fibrillation

Alzoughool

Atoum

Abu-Awad

et al. 2020

Public Health Genomics

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“…However, many studies have suggested that genetic factors play an important role in AF occurrence and development [9]. In fact, common genetic variants (a multitude of single-nucleotide polymorphisms [SNPs]) associated with AF have been detected in genome-wide association studies (GWASs) [10][11][12], such as endothelial nitric oxide synthase 786T/C, CYP11B2 rs1799998, KCNE1 G38S, and caveolin-1 rs3807989 [9,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Wu¹,

Chu²,

Zhuang³

2021

Preprint

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Background Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations. Methods The PubMed, Embase, and Wanfang databases were searched, covering all publications before July 20, 2020. Results Overall, seven articles including 3,674 cases and 8,990 healthy controls for ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. The odds ratio (OR) [95% confidence interval (CI)] was used to assess the associations. Publication bias was calculated using Egger’s and Begg’s tests. We found that the ZFHX3 rs2106261 polymorphism increased AF risk in Asians (for example, allelic contrast: OR [95% CI]: 1.39 [1.31–1.47], P < 0.001). Similarly, strong associations were detected through stratified analysis using source of control and genotype methods (for example, allelic contrast: OR [95% CI]: 1.51 [1.38–1.64], P < 0.001 for HB; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for PB; OR [95% CI]: 1.55 [1.33–1.80], P < 0.001 for TaqMan; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for high-resolution melt). In contrast, an inverse relationship was observed between the PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR [95% CI]: 0.83 [0.77–0.99], P = 0.036; CT vs. TT: OR [95% CI]: 0.79 [0.67–0.94], P = 0.006). No obvious evidence of publication bias was observed. Conclusion In summary, our study suggests that the ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms are associated with AF risk, and larger case-controls must be carried out to confirm the above conclusions.

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“…However, many evidences support that genetic factors play an important role in its occurrence and development [9]. In fact, common genetic variants (a multitude of single-nucleotide polymorphism, SNPs) associated with AF have been detected in Genome-wide association studies (GWAS) [10][11][12]: such as endothelial nitric oxide synthase 786T/C, CYP11B2 rs1799998, KCNE1 G38S, Caveolin-1 rs3807989 [9,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Association Between ZFHX3 and PRRX1 Genes’ Two Common Polymorphisms and Atrial Fibrillation Susceptibility in Asians

Wu¹,

Chu²,

Zhuang³

2020

Preprint

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BackgroundOne of the common sustained cardiac arrhythmia disorders is atrial fibrillation (AF), nowadays, results concerning the associations between ZFHX3/PRRX1 genes and AF has been widely reported. A meta-analysis to confirm above associations is necessary to be carried out in time. MethodsThe PubMed, Embase and Wanfang databases were conducted for searching, covering all publications before 20th July, 2020. ResultsOverall, seven articles including 3,674 cases and 8,990 healthy controls about ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. Odds ratio (OR)[95% confidence interval (CI)] was applied to assess the associations. Publication bias was calculated by both Egger’s and Begg’s tests. After calculated, we found that ZFHX3 rs2106261 polymorphism potential increased AF risk in Asians (for example: allelic contrast: OR [95%CI]: 1.39[1.31-1.47], P < 0.001). Similarly, stratified analysis by source of control and genotype method, also increased associations were detected (for example: allelic contrast: OR[95%CI] = 1.51[1.38-1.64], P < 0.001 for HB; OR[95%CI]: 1.31[1.21-1.41], P < 0.001 for PB; OR[95%CI] = 1.55[1.33-1.80], P < 0.001 for TaqMan; OR[95%CI] = 1.31[1.21-1.41], P < 0.001 for HRM). On the other hand, decreased relationship was observed between PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR[95%CI] = 0.83[0.77-0.99], P = 0.036; CT vs. TT: OR[95%CI] = 0.79[0.67-0.94], P = 0.006). No obvious evidence of publication bias was found. ConclusionsIn summary, our study suggested that ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms had positive associations with AF risk, more large case-controls must be carried out to confirm above conclusions.

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Association between KCNE1 G38S gene polymorphism and risk of atrial fibrillation

Abstract: Supplemental Digital Content is available in the text

Cited by 9 publications

References 36 publications

The rs2236609 Polymorphism Is Related to Increased Risk Susceptibility of Atrial Fibrillation

The rs2236609 Polymorphism Is Related to Increased Risk Susceptibility of Atrial Fibrillation

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Association Between ZFHX3 and PRRX1 Genes’ Two Common Polymorphisms and Atrial Fibrillation Susceptibility in Asians

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