Association Between Ischemic Stroke and COVID-19 in China: A Population-Based Retrospective Study

Wang, Minghuan; Zhang, Han; He, Yuqin; Qin, Chuan; Liu, Xingyuan; Liu, Mingqian; Tang, Yuhong; Li, Xiaohua; Yang, Guang; Tang, Yingxin; Liang, Gang; Xu, Shabei; Wang, Wei

doi:10.3389/fmed.2021.792487

Cited by 7 publications

(8 citation statements)

References 35 publications

(38 reference statements)

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“…The fact that we had a higher percentage of COVID-19 (+) patients with a history of stroke who required ICU management or mechanical ventilation may be in part due to the low absolute number of patients with a history of stroke. However, prior large cohort studies have shown that COVID-19 (+) with a prior history of stroke tend to be older, have more comorbidities and develop worse clinical outcomes after COVID-19 [12,13].…”

Section: Discussionmentioning

confidence: 98%

Acute Decompensated Heart Failure in Patients With and Without COVID-19 — The Experience of a Romanian Center

Vintila

Horumba

Miron

et al. 2022

Romanian Journal of Cardiology

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Objective Our goal was to characterize a cohort of heart failure patients with and without COVID-19 in terms of demographics, comorbid conditions, treatment regimens, lab test results and outcome. Methods We performed a retrospective, unicentric, cohort study on consecutive patients admitted to our department between September and December 2021. Results We enrolled a total of 76 HF patients – 65.3% COVID-19 (+). The median age was 72 years with a female predominance (59.2%). The median length of hospitalization was 13 days, longer for COVID-19 (+). Only 20.7% of all patients were fully vaccinated. COVID-19 (+) patients had higher ICU admission rates and mortality (in-hospital and at follow-up). The most common associated conditions were HTN (78.9%), T2DM (38.2%), cancer (18.4%), CAD (17.1%), late-stage CKD (16.7%), AF (14.5%) and stroke (11.8%). Patients with a history of stroke were more likely to require ICU management. At-home treatment with ACEi/ARB/ARNi made no difference for COVID-19 severity (p = 0.393), mechanical ventilation (p = 0.101) or mortality (in-hospital: p = 0.316; follow-up: p = 0.563); however, ICU admission rates were lower in these patients (p = 0.023). Conclusion Heart failure with preserved ejection fraction and low symptom severity were common findings among COVID-19 positive patients. However, COVID-19 positive patients were hospitalized for longer, required more ICU care and had higher mortality both in-hospital and at follow-up.

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Section: Discussionmentioning

confidence: 98%

Acute Decompensated Heart Failure in Patients With and Without COVID-19 — The Experience of a Romanian Center

Vintila

Horumba

Miron

et al. 2022

Romanian Journal of Cardiology

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“…COVID-19 was first reported in Wuhan, China. There is no doubt that the city's experience has provided researchers with valuable information regarding the characterization and early treatment of COVID-19-related neurological disorders ( 31 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

“…Schultz et al ( 57 ) found that a 0.55% incidence of CVT within 1 month since the first dose vaccination and that women are more likely to develop CVT after vaccination. Mechanistically, RAS system imbalance, endothelial damage, cytokine storm, hypercoagulable state, and impaired immune function are suspected to contribute to acute cerebrovascular events and deserve more research in future ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of COVID-19 publications in neurology by using the visual mapping method

Zhang

Weng

2022

Front. Public Health

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BackgroundThe characteristic symptom of coronavirus disease 2019 (COVID-19) is respiratory distress, but neurological symptoms are the most frequent extra-pulmonary symptoms. This study aims to explore the current status and hot topics of neurology-related research on COVID-19 using bibliometric analysis.MethodsPublications regarding neurology and COVID-19 were retrieved from the Web of Science Core Collection (WoSCC) on March 28 2022. The Advanced search was conducted using “TS = (‘COVID 19’ or ‘Novel Coronavirus 2019’ or ‘Coronavirus disease 2019’ or ‘2019-nCOV’ or ‘SARS-CoV-2’ or ‘coronavirus-2’) and TS = (‘neurology’or ‘neurological’ or ‘nervous system’ or ‘neurodegenerative disease’ or ‘brain’ or ‘cerebra’ or ‘nerve’)”. Microsoft Excel 2010 and VOSviewer were used to characterize the largest contributors, including the authors, journals, institutions, and countries. The hot topics and knowledge network were analyzed by CiteSpace and VOSviewer.ResultsA total of 5,329 publications between 2020 and 2022 were retrieved. The United States, Italy, and the United Kingdom were three key contributors to this field. Harvard Medical School, the Tehran University of Medical Sciences, and the UCL Queen Square Institute of Neurology were the major institutions with the largest publications. Josef Finsterer from the University of São Paulo (Austria) was the most prolific author. Tom Solomon from the University of Liverpool (UK) was the most cited author. Neurological Sciences and Frontiers in Neurology were the first two most productive journals, while Journal of Neurology held the first in terms of total citations and citations per publication. Cerebrovascular diseases, neurodegenerative diseases, encephalitis and encephalopathy, neuroimmune complications, neurological presentation in children, long COVID and mental health, and telemedicine were the central topics regarding the neurology-related research on COVID-19.ConclusionNeurology-related research on COVID-19 has attracted considerable attention worldwide. Research topics shifted from “morality, autopsy, and telemedicine” in 2020 to various COVID-19-related neurological symptoms in 2021, such as “stroke,” “Alzheimer's disease,” “Parkinson's disease,” “Guillain–Barre syndrome,” “multiple sclerosis,” “seizures in children,” and “long COVID.” “Applications of telemedicine in neurology during COVID-19 pandemic,” “COVID-19-related neurological complications and mechanism,” and “long COVID” require further study.

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“…Acute ischemic stroke concomitant with SARS-CoV-2 infection has been extensively described in the literature [ 28 , 52 •, 53 – 60 , 61 •, 62 ] ranging from 0.9 to 4.6% (Table 1 ). A representative CT scan image of patients with COVID-19 diagnosed with ischemic stroke in the distribution of the right posterior cerebral in the presence of vascular risk factors is shown in Fig.…”

Section: Clinical Cerebrovascular Manifestation Of Sars-cov-2mentioning

confidence: 99%

“…Intriguingly, some later studies indicated a different prevalence. In a retrospective study of 36,358 hospitalized patients from Wuhan, only 124 (0.34%) were diagnosed with AIS, which was correlated with severity of infection [ 53 ]. Furthermore, a multicentre study from New York identified 22 AIS incidents from 2513 COVID-19 cases (0.9%), with an OR of 0.35 (95% CI = 0.23–0.55) compared to a non-COVID-19 cohort [ 59 ].…”

Section: Clinical Cerebrovascular Manifestation Of Sars-cov-2mentioning

confidence: 99%

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review

Stefanou¹,

Karvelas

Bennett

et al. 2023

Curr Treat Options Neurol

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Purpose of review The risks of cerebrovascular manifestations due to SARS-CoV-2 infection are significantly increased within the first 6 months of the infection. Our work aims to give an update on current clinical aspects of diagnosis and treatment of cerebrovascular manifestations during acute and long-term SARS-CoV-2 infection. Recent findings The incidence of acute ischemic stroke and haemorrhagic stroke during acute SARS-CoV-2 patients is estimated at 0.9 to 4.6% and 0.5–0.9%, respectively, and were associated with increased mortality. The majority presented with hemiparesis, dysarthria, sensory deficits, and a NIHSS score within 5–15. In addition, beyond the first 30 days of infection people with COVID-19 exhibited increased risk of stroke. During acute phase, age, hypertension, diabetes, and medical history of vascular disease were increased in patients with COVID-19 with new onset of cerebrovascular manifestations, while during long-COVID-19, the risk of cerebrovascular manifestations were found increased regardless of these factors. The management of patients with large-vessel ischemic stroke fulfilling the intravenous thrombolysis criteria are successfully treated according to the guidelines, while hyperosmolar therapy is typically administered in 4- to 6-h intervals. In addition, prophylaxis of anticoagulation therapy is associated with a better prognosis and low mortality during acute and post hospital discharge of patients with COVID-19. Summary In this work, we provide a comprehensive review of the current literature on acute and post-acute COVID-19 cerebrovascular sequelae, symptomatology, and its pathophysiology mechanisms. Moreover, we discuss therapeutic strategies for these patients during acute and long-term care and point populations at risk. Our findings suggest that older patients with risk factors such as hypertension, diabetes, and medical history of vascular disease are more likely to develop cerebrovascular complications.

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Association Between Ischemic Stroke and COVID-19 in China: A Population-Based Retrospective Study

Cited by 7 publications

References 35 publications

Acute Decompensated Heart Failure in Patients With and Without COVID-19 — The Experience of a Romanian Center

Acute Decompensated Heart Failure in Patients With and Without COVID-19 — The Experience of a Romanian Center

A bibliometric analysis of COVID-19 publications in neurology by using the visual mapping method

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review

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