Association between iron status and febrile seizures in children

Zareifar, Soheila; Hosseinzadeh, Hamid Reza Seyyed; Cohan, Nader

doi:10.1016/j.seizure.2012.06.010

Cited by 31 publications

(38 citation statements)

References 20 publications

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“…Of the previously reported associations we examined (5-7, 9, 13-24, 26), only positive family history for FS (5) and iron deficiency (9,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) were risk factors in our prospective case control study.…”

Section: Discussionmentioning

confidence: 76%

“…Iron plays a critical role in the metabolism of several neurotransmitters as well as in myelination (10)(11)(12) and deficiency is associated with a number of neurological conditions in children including developmental delay, stroke, breath-holding attacks and cranial nerve palsies (11,12). Iron deficiency (ID) might therefore lower the seizure threshold (14) but there is controversy over whether there is an association with FS (9,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), most conducted in the Developing World (24). In this study we investigate whether there is any association between ID and occurrence of FS in Greek preschoolers.…”

Section: Introductionmentioning

confidence: 99%

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Association between iron deficiency and febrile seizures

Papageorgiou

Vargiami

Kontopoulos

et al. 2015

European Journal of Paediatric Neurology

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Highlights• Greek children with FS have lower levels of plasma ferritin and higher levels of TIBC than controls, implying an association with iron deficiency although haemoglobin levels were non-significantly higher• In children with complex FS, the levels of plasma ferritin are significantly lower and TIBC significantly higher than controls.• Children in whom the index febrile seizure was a recurrence were more likely to be iron deficient but with a higher haemoglobin and mean cell haemoglobin concentration than those with a first seizure Conclusions: European children with febrile seizures have lower Ferritin than those with fever alone, and iron deficiency, but not anaemia, is associated with recurrence. Iron status screening should be considered as routine for children presenting with or at high risk for febrile seizures.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Association between iron deficiency and febrile seizures

Papageorgiou

Vargiami

Kontopoulos

et al. 2015

European Journal of Paediatric Neurology

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“…Some studies showed iron deficiency and iron deficiency anemia were more frequent in children with FS [13][14][15]; and in other research, serum and cerebrospinal fluid zinc levels of children with FS were significantly lower than in children with febrile illness and afebrile seizure [5][6][7][8][9]16].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial

et al. 2015

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“…The frequency of low serum iron was reported to be as high as 56.2% in Shiraz (Iran) and it was 30.5% in Kenya [7,10]. Also, it has been hypothesized that iron deficiency could be important in brain development and that so, it should be noticed and treated more urgently [11].…”

Section: Discussionmentioning

confidence: 99%