Association between iron deficiency anemia and various red cell parameters with febrile convulsions in children of age group 3 to 60 months

Kamalammal, Rugmini; Balaji, M D

doi:10.18203/2349-3291.ijcp20161038

Cited by 6 publications

(5 citation statements)

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“…The mean MCH was significantly lower in cases than that in the control group (p=0.002) which is similar to the studies by Kamalammal and Balaji [19] and Karimi et al [20]. In the present study, the mean MCHC in cases was significantly lower than that in controls (p=0.0001) which is similar to the study by Kamalammal and Balaji [19].…”

Section: Discussionsupporting

confidence: 91%

“…The mean MCV for the case group was less than that of the control group (p=0.0004) which is according to the results obtained by Shaikh et al [18] and Kamalammal and Balaji [19]. The mean MCH was significantly lower in cases than that in the control group (p=0.002) which is similar to the studies by Kamalammal and Balaji [19] and Karimi et al [20]. In the present study, the mean MCHC in cases was significantly lower than that in controls (p=0.0001) which is similar to the study by Kamalammal and Balaji [19].…”

Section: Discussionsupporting

confidence: 88%

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A case–control study to find the association between iron deficiency anemia and simple febrile seizures in children between 6 months and 5 years of age group

Vaghela¹,

Mandot²

2020

Indian J Child Health

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Background: Simple febrile seizure (FS) is the most common type of childhood seizure. Iron plays an important role in brain metabolism, neurotransmitter function, and myelination. Iron deficiency anemia (IDA) has been found to be associated with an increased incidence of FS. Objective: The objective of the study was to study the prevalence of IDA in simple FS patients and febrile patients without seizure. Materials and Methods: All admitted febrile children between 6 months and 5 years were enrolled in the study according to the inclusion and exclusion criteria and a detailed clinical examination was done. Blood samples were collected for complete blood count, blood indices, and serum ferritin. Results: IDA was present in 28 out of 50 patients in the case group and 18 of 50 patients in the control group (p<0.05). Mean hemoglobin and mean serum ferritin levels were significantly lower in the case group when compared to the control group (p<0.05). Conclusion: All the investigations carried out to evaluate the IDA were significantly lower in the case group as compared to the control group. This suggested that iron-deficient children were more prone to get FS.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

A case–control study to find the association between iron deficiency anemia and simple febrile seizures in children between 6 months and 5 years of age group

Vaghela¹,

Mandot²

2020

Indian J Child Health

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“…On the contrary, Kamalammal and Balaji,[14] in 2016, observed that the HB, MCH, MCHC, and serum ferritin levels did not show any significant differences between the two groups, and only serum iron level was less in the case group than that in the control group. Also Sharif et al ,[15] in 2016, reported that only low serum iron level was associated with FCs, with a lack of significant difference in HB and with significantly higher TIBC level among the cases than that in the controls, these results differ from our results.…”

Section: Discussionmentioning

confidence: 96%

Relation of iron and zinc deficiencies to the occurrence of febrile convulsions

et al. 2019

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A bstract Context: Febrile convulsion is one of the most important types of convulsions in children. Iron and zinc are important trace elements that affect some enzymes in central nervous system, and their deficiencies could disturb the inhibitory mechanisms in the brain, thus producing convulsions. Aim: To evaluate the relation between iron deficiency, zinc deficiency, and febrile convulsions. Settings and Design: A cross-sectional study was carried out. Subjects and Methods: The study included 100 children of the pediatric hospital in Assiut University, Assiut, Egypt; 50 children with febrile convulsions as the study group and 50 febrile children without convulsions as the control group. Statistical Analysis: The Statistical Package for the Social Sciences (SPSS) software, version 20, was used for statistical analysis. Results: The mean value of hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration iron, and ferritin were significantly lower in cases than that in the control group. Significantly, zinc level was lower in 68% of cases and 36% of control children. Moreover, the mean value of zinc was significantly lower in cases than that in the control group. Conclusion: Lower levels of iron and zinc seem to be predisposing factors for developing febrile convulsions.

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“…A study by Waheed et al reported that iron concentration is not linked to the development of FS 16 . In another study, Kamalammal et al evaluated the association between IDA and FS in children aged 3 to 60 months and observed that there are no significant differences and rejected the claim that IDA is a triggering factor for FS 17 . Similarly, Bharat et al failed to establish any link between IDA and FS 8 .…”

Section: Discussionmentioning

confidence: 99%

The association of iron deficiency anaemia with simple febrile seizures in children less than 5 years age: A single centre, prospective, case-control study

Madavi

Kumar

Nashine

2021

Sri Lanka J Child Health

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Introduction: Febrile seizure (FS) has an incidence of 2-5% in the neurologically healthy child. Among various risk factors, iron deficiency anaemia (IDA) is implicated in the increased risk of FS. Objectives: To primarily assess the association between IDA and simple FS and secondarily the association of other risk factors with simple FS. Method: This was a single centre, prospective, case control study involving 120 children, aged between 6 months and 5 years, 60 presenting with simple FS (cases) and 60 presenting with acute febrile episodes without seizures (controls). The study was performed from September 2017 to August 2019. Cases and controls were matched for age, sex, weight, and height. Laboratory investigations such as complete blood count, serum iron (SI), total iron binding capacity (TIBC), and SI/TIBC index were performed and compared between the two groups. Results: Compared to controls, significantly higher number of cases had a family history of FS and family history of seizure disorder (both p-values<0.05). Moreover, as compared to controls, cases had significantly lower median haemoglobin levels, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration (all p-values<0.05). However, cases had significantly higher median red cell distribution width (p-value = 0.004). Similarly, cases had a significantly lower mean SI levels, and SI/TIBC index, as compared to controls (both p-values<0.05). However, cases had significantly higher mean TIBC (p-values<0.05

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Association between iron deficiency anemia and various red cell parameters with febrile convulsions in children of age group 3 to 60 months

Cited by 6 publications

References 10 publications

A case–control study to find the association between iron deficiency anemia and simple febrile seizures in children between 6 months and 5 years of age group

A case–control study to find the association between iron deficiency anemia and simple febrile seizures in children between 6 months and 5 years of age group

Relation of iron and zinc deficiencies to the occurrence of febrile convulsions

The association of iron deficiency anaemia with simple febrile seizures in children less than 5 years age: A single centre, prospective, case-control study

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