A case–control study to find the association between iron deficiency anemia and simple febrile seizures in children between 6 months and 5 years of age group

Abstract

Background: Simple febrile seizure (FS) is the most common type of childhood seizure. Iron plays an important role in brain metabolism, neurotransmitter function, and myelination. Iron deficiency anemia (IDA) has been found to be associated with an increased incidence of FS. Objective: The objective of the study was to study the prevalence of IDA in simple FS patients and febrile patients without seizure. Materials and Methods: All admitted febrile children between 6 months and 5 years were enrolled in the study according to the inclusion and exclusion criteria and a detailed clinical examination was done. Blood samples were collected for complete blood count, blood indices, and serum ferritin. Results: IDA was present in 28 out of 50 patients in the case group and 18 of 50 patients in the control group (p<0.05). Mean hemoglobin and mean serum ferritin levels were significantly lower in the case group when compared to the control group (p<0.05). Conclusion: All the investigations carried out to evaluate the IDA were significantly lower in the case group as compared to the control group. This suggested that iron-deficient children were more prone to get FS.

Assessment of Serum Carnitine level in Children with Iron Deficiency Anemia

“…In accordance with our results, the study of Das et al [14] as they provided evidence indicating that levels of serum iron and ferritin were notably reduced in patients diagnosed with iron deficiency anemia [IDA] in comparison to the control group. Also, our results were in line with a study by Vaghela and Mandot [15].…”

Iron Deficiency Association as A Possible Cause of First Febrile Seizure

“…In patients with iron deficiency, the metabolism of monoamines and aldehyde oxidases is lowered, so the threshold for iron deficiency children is low and the risk of febrile seizures (FS) increases [4][5] . The type of iron deficiency may affect duration and recurrence of seizures [6][7] . FS is the most common form of childhood seizures 8 .…”