Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years

Menezes, Ana Maria Baptista; Oliveira, Paula Duarte de; Wehrmeister, Fernando César; Gonçalves, Helen; Assunção, Maria Cecília Formoso; Tovo‐Rodrigues, Luciana; Ferreira, Gustavo Dias; Oliveira, Isabel

doi:10.1016/j.cyto.2018.04.020

Cited by 18 publications

(20 citation statements)

References 51 publications

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“…This can be seen in the Additional file 3 : Table S2; there was a positive association between BMD and the exposures in the crude analysis, but the addition of all confounders in the full adjusted model changed the direction of the association from positive to negative regression coefficients; if we do not add BMI as a confounder, the direction of the association does not change. BMI is highly associated with IL-6 and CRP in a positive direction according to our previous paper on the same cohort [ 8 ]. Any analysis on the association of these cytokines and densitometry should always take into account adiposity, otherwise the results can be misleading.…”

Section: Discussionmentioning

confidence: 77%

“…Any analysis on the association of these cytokines and densitometry should always take into account adiposity, otherwise the results can be misleading. On the other hand, adiponectin is inversely associated with BMI [ 8 ], therefore, the inclusion of this covariate in the model did not change the direction of the association with BMD, with an inverse beta remaining in most of the unadjusted and adjusted analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between cytokines and BMD should be evaluated considering potential confounders, such as obesity, since a positive IL-6 and CRP association and a negative adiponectin and adiposity association have been demonstrated [ 8 – 10 ]. Other variables may also be responsible for this association such as health behaviors (physical activity, smoking and drinking), socioeconomic status, morbidities, diet and hormonal levels; in addition to these exposures, it is known that smoking during pregnancy, gestational age and birth weight can also influence bone health during life [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Menezes

Oliveira

Gonçalves

et al. 2018

BMC Musculoskelet Disord

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BackgroundStudies have shown that cytokines play a role in bone remodeling.MethodsIn 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. At 18 and 22 years the following biomarkers were measured: IL-6, CRP and adiponectin (the last one in a sub-sample) and bone mineral density (BMD-mg/cm2) was evaluated at 22 years. Crude regression analysis as well as adjusted for confounders (birth weight, pregnancy maternal smoking, gestational age, skin color, schooling, income, smoking, alcohol, physical activity, medical diagnosis of asthma, diabetes and hypertension, BMI, height, calcium intake, corticosteroid use, age at menarche, insulin and testosterone) were performed between the three biomarkers and the whole-body, lumbar spine and femoral BMD.ResultsNo statistical significant association was found between IL-6 and CRP with BMD, in males. Significant inverse association in the adjusted analysis, among females, was found for the highest tertiles of CRP at 22 y (beta − 15.2 mg/cm2; 95% CI: -25.4; − 4.9; p = 004), of CRP and IL-6 at 22 years (beta − 20.0 mg/cm2; 95% CI: -31.7; − 8.3; p = 0.003), and of IL-6 and CRP at both ages (beta − 20.3 mg/cm2; 95% CI: -38.0; − 2.5; p = 0.001) with total body BMD. Significant association, among males, was also found between the highest tertile of adiponectin at 22 y (beta − 23.3 mg/cm2; 95% CI: -35.5; − 11.1; p = < 001; beta − 22.5 mg/cm2; 95% CI: -42.9; − 2.2; p = 0.03; and beta − 31.8 mg/cm2; 95% CI: -55.5; − 9.1; p = 0.006) and total body, lumbar spine and femur neck BMD, respectively; and, among females, − 17.8 mg/cm2; 95% CI: -34.9; − 0.9; p = 0.033, with lumbar spine BMD.ConclusionCRP at 22 years, in females, seems to be a marker for total body BMD; adiponectin at 22 years is also a marker for BMD at the three sites, in males, and for lumbar spine BMD, in females.Electronic supplementary materialThe online version of this article (10.1186/s12891-018-2357-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Menezes

Oliveira

Gonçalves

et al. 2018

BMC Musculoskelet Disord

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“…Visceral obesity and type 2 diabetes are associated with low levels of adiponectin [18]. It also displays anti-inflammatory and anti-atherogenic properties [19–22], regulates bone metabolism [23], and protects the heart from ischemia [24].…”

Section: Introductionmentioning

confidence: 99%

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

et al. 2018

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“…A birth cohort study aimed at assessing the association of obesity with physiological markers at 22 years of age, showing direct association for IL-6 and CRP and an inverse association for adiponectin, suggesting early care for this population at risk. 36 A meta-analysis of prospective studies suggests the association of IL-6 and CRP with type 2 diabetes risk (relative risk of 1.31 per 1 log pg/mL increment in IL-6 levels and of 1.26 per 1 log mg/L increment in CRP levels). 37 …”

Section: Discussionmentioning

confidence: 99%

Physiological markers and multimorbidity

et al. 2018

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Background:Multimorbidity is the co-occurrence of two or more diseases in the same individual. One method to identify this condition at an early stage is the use of specific markers for various combinations of morbidities. Nonetheless, evidence related to physiological markers in multimorbidity is limited.Objective:The aim was to perform a systematic review to identify physiological markers associated with multimorbidity.Design:Articles available on PubMed, Register of Controlled Trials, Academic Search Premier, CINAHL, Scopus, SocINDEX, Web of Science, LILACS, and SciELO, from their inception to May 2018, were systematically searched and reviewed. The project was registered in PROSPERO under the number CRD42017055522.Results:The systematic search identified 922 papers. After evaluation, 18 articles were included in the full review reporting at least one physiological marker in coexisting diseases or which are strongly associated with the presence of multimorbidity in the future. Only five of these studies examined multimorbidity in general, identifying five physiological markers associated with multimorbidity, namely, dehydroepiandrosterone sulfate (DHEAS), interleukin 6 (IL-6), C-reactive protein (CRP), lipoprotein (Lp), and cystatin C (Cyst-C).Conclusions:There is a paucity of studies related to physiological markers in multimorbidity. DHEAS, IL-6, CRP, Lp, and Cyst-C could be the initial focus for further investigation of physiological markers related to multimorbidity.

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Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years

Cited by 18 publications

References 51 publications

Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Physiological markers and multimorbidity

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Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years

Cited by 18 publications

References 51 publications

Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Physiological markers and multimorbidity

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Product

Resources

About

Association between interleukin-6, C-reactive protein and adiponectin with adiposity: Findings from the 1993 pelotas (Brazil) birth cohort at 18 and 22 years