Are cytokines (IL-6, CRP and adiponectin) associated with bone mineral density in a young adult birth cohort?

Abstract

BackgroundStudies have shown that cytokines play a role in bone remodeling.MethodsIn 1993, all hospital births occurred in Pelotas (Brazil) were identified and a total of 5249 newborns were included in the present cohort. Sub-samples of this cohort were visited during childhood and all members were traced at 11, 15, 18 and 22 years old. At 18 and 22 years the following biomarkers were measured: IL-6, CRP and adiponectin (the last one in a sub-sample) and bone mineral density (BMD-mg/cm2) was evaluated at 22 years. Crude regression analysis as well as adjusted for confounders (birth weight, pregnancy maternal smoking, gestational age, skin color, schooling, income, smoking, alcohol, physical activity, medical diagnosis of asthma, diabetes and hypertension, BMI, height, calcium intake, corticosteroid use, age at menarche, insulin and testosterone) were performed between the three biomarkers and the whole-body, lumbar spine and femoral BMD.ResultsNo statistical significant association was found between IL-6 and CRP with BMD, in males. Significant inverse association in the adjusted analysis, among females, was found for the highest tertiles of CRP at 22 y (beta − 15.2 mg/cm2; 95% CI: -25.4; − 4.9; p = 004), of CRP and IL-6 at 22 years (beta − 20.0 mg/cm2; 95% CI: -31.7; − 8.3; p = 0.003), and of IL-6 and CRP at both ages (beta − 20.3 mg/cm2; 95% CI: -38.0; − 2.5; p = 0.001) with total body BMD. Significant association, among males, was also found between the highest tertile of adiponectin at 22 y (beta − 23.3 mg/cm2; 95% CI: -35.5; − 11.1; p = < 001; beta − 22.5 mg/cm2; 95% CI: -42.9; − 2.2; p = 0.03; and beta − 31.8 mg/cm2; 95% CI: -55.5; − 9.1; p = 0.006) and total body, lumbar spine and femur neck BMD, respectively; and, among females, − 17.8 mg/cm2; 95% CI: -34.9; − 0.9; p = 0.033, with lumbar spine BMD.ConclusionCRP at 22 years, in females, seems to be a marker for total body BMD; adiponectin at 22 years is also a marker for BMD at the three sites, in males, and for lumbar spine BMD, in females.Electronic supplementary materialThe online version of this article (10.1186/s12891-018-2357-3) contains supplementary material, which is available to authorized users.

C‐reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat

“…Our study confirmed several clinical studies, which indicated that CRP is inversely correlated with bone metabolism under chronic inflammatory conditions (Berglundh et al, 2015; Menezes et al, 2018). In addition, several research studies have proven that decreasing CRP levels could be a therapy for some diseases, including cardiovascular disease, ischaemia/reperfusion injury, and orthotopic breast cancer (Jimenez & Szalai, 2020).…”

“…*p < .05, **p < .01, ***p < .001. Ad-Cont, control adenovirus; Ad-CRP, adenovirus-mediated CRP overexpression; Lv-shCont, control lentivirus; Lv-shCRP, lentivirus-mediated CRP knockdown inflammatory conditions (Berglundh et al, 2015;Menezes et al, 2018). In addition, several research studies have proven that decreasing CRP levels could be a therapy for some diseases, including cardiovascular disease, ischaemia/reperfusion injury, and orthotopic breast cancer (Jimenez & Szalai, 2020).…”

High-sensitivity C-reactive protein could be a potential indicator of bone mineral density in adolescents aged 10–20 years

“…Till now, there is very limited evidence linking HS-CRP and BMD in adolescents. A recent cross-sectional study of 5249 in a young adult birth cohort that found a CRP showed a negative association with total BMD in females but no association in males 13 . Their findings were partially consistent with the results of our subgroup analysis.…”

“…However, a study by Menezes et al . showed that CRP levels had no relationship with BMD or plasma osteocalcin levels, which is a bone turnover marker 13 . Berglundh et al .…”

Relationship of Bone Mineral Density and Vascular Wall Condition With Biochemical Markers of Inflammation in Postmenopausal Women

“…Результаты данного исследования подтверждают связь параметров сосудистой жесткости, субклинического атеросклероза и МПК с длительностью постменопаузального периода. С нарастанием продолжительно-О р и г и н а л ь н ы е и с с л е д о в а н и я была доказана в когорте молодых женщин, в отличие от мужчин [14]. А в одном исследовании были получены противоречивые данные о низком уровне СРБ у лиц с ОП по сравнению с остеопенией, в то время как высокий уровень ИЛ6 ассоциировался с низкой костной массой только в ПОБ [15].…”