Association Between Inflammatory Markers and Liver Fat: The Multi-Ethnic Study of Atherosclerosis

Hamirani, Yasmin S.; Nasir, Khurram; Blaha, Michael J.; Katz, Ronit; Blumenthal, Roger S.; Kronmal, Richard; Budoff, Matthew J.

doi:10.1016/s0735-1097(12)61345-x

Cited by 12 publications

(18 citation statements)

References 22 publications

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“…Recent studies have shown novel roles for inflammatory mediators in the link between NAFLD/NASH and inflammation. In the Multi‐Ethnic Study of Atherosclerosis, which is a longitudinal, population‐based study of four ethnic groups free of CVD at baseline, levels of interleukin‐6 (IL‐6) were significantly associated with liver fat assessed via CT after adjusting for other risk factors for atherosclerosis . Toll‐like receptors (TLRs), which are well‐characterized immune receptors, activate proinflammatory pathways .…”

Section: Pathological Role Of Nafld and Cardiometabolic Syndromementioning

confidence: 99%

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

2018

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Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue and de novo lipogenesis can lead to NAFLD and insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidaemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is a phenotype of cardiometabolic syndrome. Notably, researchers have discovered a close association between NAFLD and impaired glucose metabolism and focused on the role of NAFLD in the development of type 2 diabetes. Moreover, recent studies provide substantial evidence for an association between NAFLD and atherosclerosis and cardiometabolic disorders. Even if NAFLD can progress into severe liver disorders including nonalcoholic steatohepatitis (NASH) and cirrhosis, the majority of subjects with NAFLD die from cardiovascular disease eventually. In this review, we propose a potential pathological link between NAFLD/NASH and cardiometabolic syndrome. The potential factors that can play a pivotal role in this link, such as inflammation, insulin resistance, alteration in lipid metabolism, oxidative stress, genetic predisposition, and gut microbiota are discussed. KEYWORDS cardiometabolic syndrome, nonalcoholic fatty liver disease, inflammation, oxidative stress 1 | INTRODUCTION | Prevalence of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH)NAFLD covers a spectrum of diseases ranging from simple steatosis to NASH, which is distinguished from the former by the presence of progressive hepatic fibrosis. 1,2 The prevalence of NAFLD or NASH in the general population varies according to the diagnostic criteria and tools used to stage the condition. 3,4 In the United States, liver biopsies performed on potential liver donors revealed that 20% of donors were ineligible for organ donation because of a high degree of steatosis (>30%). 5 A study in which liver biopsies were performed on 589 consecutive potential liver-transplant donors found an NAFLD prevalence of 51%. 6 A series of autopsies showed a broad range in the prevalence of NAFLD. The prevalence of NASH in autopsy cases of lean Abbreviations: ALT, alanine aminotransferase; apoB, apolipoprotein-B; AST, aspartate aminotransferase; ChREBP, carbohydrate-responsive element-binding protein; CV, cardiovascular; ER, endoplasmic reticulum; FFA, free fatty acid; FIAF, fasting-induced adipocyte factor; GSK-3β, glycogen synthase kinase-3β; IL-6, interleukin-6; IRS1, insulin receptor substrate-1

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Section: Pathological Role Of Nafld and Cardiometabolic Syndromementioning

confidence: 99%

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

2018

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“…In hospital-based cohorts, several studies observed an association between those with NAFLD or hepatic fibrosis and measures of systemic inflammation. 17,18,[27][28][29][19][20][21][22][23][24][25][26] Prior studies of the association between NAFLD and inflammatory makers have largely been limited by small sample sizes 16,17,[31][32][33]18,20,24,25,[27][28][29][30] or measurement of a single or few inflammatory markers 10,14,35,15,19,21,22,24,25,33,34 , and have predominantly included those with more advanced NAFLD. 23,26,29 The relationship between hepatic steatosis and systemic inflammation among community-dwellers not selected for liver disease has largely been unexplored.…”

Section: Introductionmentioning

confidence: 99%

Liver Fat Is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study

Fricker

Pedley

Massaro

et al. 2019

Clinical Gastroenterology and Hepatology

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“…Several previous studies have investigated the relationship between hs-CRP and fatty liver [ 16 ]. Al Rifai et al conducted a cross-sectional analysis of 3,976 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), which diagnosed fatty liver through computed tomography imaging, and showed that NAFLD was associated with a prevalence odds ratio for hs-CRP ≥ 2 mg/L [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory biomarkers and risk of atherosclerotic cardiovascular disease

Hsu

Huang

et al. 2018

Open Medicine

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AbstractBackgroundNon-alcoholic fatty liver disease is an increasing health issue that associates with the development of atherosclerotic cardiovascular disease. This study correlates the association between fatty liver and inflammatory biomarkers with cardiovascular risk scores.MethodologyThis cross-sectional study enrolled 10,181 health examination participants from Northern Taiwan and administered a standardized questionnaire with important biochemical tests and abdominal sonography. To assess concentrations of inflammatory markers high sensitivity C-reactive protein (hs-CRP) and fibrinogen were used.ResultsInflammatory marker levels were significantly increased with increasing fatty liver. In multivariate logistic regression analysis adjusted for major confounding factors, the odds ratios of elevated hs-CRP and fibrinogen were significantly higher in participants with mild or moderate-to-severe fatty liver compared to healthy individuals. The cardiovascular risk scores, above cut-off level 10%, were associated with higher levels of inflammatory biomarkers and fatty liver; odds ratio, 3.52 (2.60-4.77) for non-alcoholic fatty liver disease with hs-CRP, and 2.92 (2.12-4.00) for non-alcoholic fatty liver disease with fibrinogen.ConclusionInflammatory biomarkers (hs-CRP and fibrinogen) are significantly associated with augmentation of fatty liver. Non-alcoholic fatty liver disease may be a predictor of future atherosclerotic cardiovascular disease, and the prediction value increases on adding inflammatory biomarkers levels.

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Association Between Inflammatory Markers and Liver Fat: The Multi-Ethnic Study of Atherosclerosis

Cited by 12 publications

References 22 publications

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

Liver Fat Is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study

Inflammatory biomarkers and risk of atherosclerotic cardiovascular disease

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