Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon

Wang, Yong; Liu, Moujie; Yang, Huimin; Ma, Chao; Jia, Pengyu; Jia, Dalin; Hou, Ai-jie

doi:10.1186/s12872-018-0873-6

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…Tambe et al described it for the first time in 1972. CSFP manifests clinically similarly to coronary atherosclerotic heart disease [8][9][10]. In agreement with our study, Mahfouz et al [11] conducted a case control study, taking patients admitted to cardiac catheterization for suspected coronary artery disease.…”

Section: Discussionsupporting

confidence: 89%

Noninvasive Predictors of Coronary Slow Flow Phenomenon in Patients Presenting with Chronic Coronary Syndrome

Mahfouz

Yassen

Mahgoub

2022

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Background: Patients with coronary slow flow phenomenon (CSFP) exhibit the following characteristics: Predominantly middle-aged males, the majority have mixed pattern angina, persistent chest pain sensations after therapy, and many have had repeated invasive and non-invasive examinations. Objectives: Our study aimed to determine the base of non-invasive predictors of coronary slow flow phenomenon in patients presenting with chronic coronary syndrome. Patients and Methods: This a case-control study included 100 participants of suspected coronary artery disease were divided into two groups matched in age and sex group I: 50 patients with primary CSFP and group II: 50 patients with normal coronary angiography. Each patient was undergoing to demographic data taking, physical investigation, good hydration, restrict fasting hours requested for coronary angiography, 12 lead-Electrocardiogram (ECG)s were obtained for each patient at rest, laboratory parameters, coronary angiography, treadmill exercise ECG, transthoracic echocardiography to assess the thickness of the left ventricle’s (LV) wall, its interior dimensions, as well as the LV’s ejection fraction (EF) using M-mood method and the aortic propagation velocity. Results: male sex and the Canadian Cardiovascular Society Angina grade’s (CCSA) class 3 were significantly decreased in group I compared to group II and male sex, Diabetes mellitus (DM), smoker and CCSA class 4 were substantially increase in group I compared to group II (P <0.05). P wave max, P Wave dispersion (PWd), corrected QT dispersion (QTcd) at resting ECG, T wave inversion and ST Waves segment depression at stress ECG were significantly increase in group I compared to group II. QTc min was significantly lower in group I compared to group II (P <0.05). LA diameter was significantly increased in group I than group II. Aortic propagation velocity was significantly decreased in group I than group II (P <0.05). Hematocrit, total leucocytic count, mean platelet volume and High-sensitivity C-reactive protein (hsCRP) were significantly increase group I compared to group II (P <0.05). Conclusions: Patients suspected of having a coronary artery disease who are diagnosed with coronary slow flow, male sex, dilated LA, CCSA class 3 or 4, elevated hematocrit value, elevated total leucocytic count, increased mean platelet volume, increased HsCRP, P max, PWd, QTcd, T wave inversion, ST segment depression, and decreased aortic propagation were statistically higher in CSFP patient compared to controls.

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Section: Discussionsupporting

confidence: 89%

Noninvasive Predictors of Coronary Slow Flow Phenomenon in Patients Presenting with Chronic Coronary Syndrome

Mahfouz

Yassen

Mahgoub

2022

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“…Experimental and clinical studies link ALP to increased vascular calcification and inflammation. Epidemiological studies have demonstrated correlations between serum ALP activity and the incidence of death [2,3] or major adverse cardiovascular events (MACE) [4,5], myocardial infarction [6], stroke [7], cerebral small vessel disease [8], re-stenosis after coronary revascularization [9], coronary slow flow phenomenon [10], and peripheral arterial disease [11]. Circulating ALP is associated with coronary calcification [12,13] and ALP activity is implicated in calcification of vascular smooth muscle cells [14].…”

Section: Introductionmentioning

confidence: 99%

Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease

et al. 2019

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Alkaline phosphatase (ALP) predicts residual cardiovascular risk in patients with cardiovascular disease on statin treatment.• Apabetalone treatment reduces circulating ALP in a dose-dependent fashion.• The reduction of circulating ALP by apabetalone is associated with a reduction in major adverse cardiovascular events (MACE).• The association of ALP reduction with MACE is independent of concurrent levels of high-sensitivity C-reactive protein.

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“…It seems that patients with CSFP may have an underlying inflammatory state and endothelial dysfunction [ 31 , 38 ]. A study by Narimani et al on CSFP patients found high LDL and low HDL levels in these patients [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic and laboratory findings in coronary slow flow phenomenon: cross-sectional study and review

Mohammadzad

Khademvatani

Gardeshkhah

et al. 2021

BMC Cardiovasc Disord

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Background Coronary sow-flow phenomenon (CSFP) is defined as slow passage of the contrast injected into the coronary arteries without distal obstruction of the vessel. Methods The present study was a cross-sectional, descriptive-analytical study performed at the Seyed-al-Shohada Heart Center during 2018–2019. The eligible patients based on the inclusion and exclusion criteria were divided into the study group showing the CSFP and the control group with normal epicardial coronary arteries. Results The study included 124 patients. 67.9% of the study group and 39.4% of the control group were male patients (p-value = 0.001), and the mean patient age was 52.18 ± 12.55 and 51.77 ± 10.36 years in the study and control groups, respectively (p-value = 0.18). The study group had a significantly higher BMI than the control group (p < 0.05) and also a higher prevalence of smoking and hypertension. The variables of ALC, Hct, Plt, MPV, RDW, Cr, triglyceride, TC, and LDL, were higher in the study group. Given the echocardiographic findings, the mean E wave was significantly lower in the study group, while the control group had a significantly higher GLS (p-value = 0.01). Also, left anterior descending artery was the most common artery involved with CSFP. Conclusion The CSFP was significantly more common in men, smokers, hypertensive patients, and patients with high BMI. Moreover, these patients had significantly higher platelet count, MPV, LDL, and FBS. Some other laboratory variables were also higher in these patients. Given the echocardiographic findings, mild diastolic dysfunction and low GLS were also observed in the study group.

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Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon

Cited by 16 publications

References 33 publications

Noninvasive Predictors of Coronary Slow Flow Phenomenon in Patients Presenting with Chronic Coronary Syndrome

Noninvasive Predictors of Coronary Slow Flow Phenomenon in Patients Presenting with Chronic Coronary Syndrome

Apabetalone lowers serum alkaline phosphatase and improves cardiovascular risk in patients with cardiovascular disease

Echocardiographic and laboratory findings in coronary slow flow phenomenon: cross-sectional study and review

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