Association between inbreeding coefficient and susceptibility to HIV-1 infection, a case-control study

Rajaei, Mehrdad; Saadat, Mostafa

doi:10.11599/germs.2013.1046

Cited by 4 publications

(7 citation statements)

References 13 publications

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“…Consanguinity also increases the probability of having homozygosity as it increases the rate of acquiring two copies of the defected recessive alleles from the common ancestor [ 13 ]. However, there are other studies that described a reverse association between consanguinity and some diseases and cancers [ 14 – 16 ]. This means that consanguinity has complicated interactions that might either increase or decrease susceptibility of certain cancers.…”

Section: Introductionmentioning

confidence: 99%

Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia

Kakaje

Alhalabi

Ghareeb

et al. 2020

BioMed Research International

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Acute lymphoblastic leukemia (ALL) is a common malignancy in children. Consanguinity has a high prevalence in developing countries and increases the probability of homozygosity for many genes which may affect ALL and its prognosis. We conducted a study to explore the impact of consanguinity and number of siblings on ALL as there are currently no studies to describe this effect. Data were collected from patients’ records from the Children’s University Hospital of Damascus University, which is the major cancer centre for children in Syria. This study included 193 children with ALL over one year. Number of siblings was not with the French–American–British (FAB) classification, gender, ALL subtype, or risk of ALL children. When comparing consanguinity degrees and complete blood counts at diagnosis, significant contradicting data were found in the third-degree and fourth-degree consanguinity when compared to one another and to not having consanguineous parents as third degree consanguinity was associated with normal platelets but lower WBC counts, and fourth-degree consanguinity was associated with normal haemoglobin levels and WBC counts, but lower platelet counts. Having consanguineous parents was also associated with acquiring ALL at an older age, L2 FAB classification, having a positive family history for malignancies, and not having hepatosplenomegaly ( P < 0.05 ). Although L2 is known to be a poor prognosis indicatory, no association was found with consanguinity and risk. Finally, no association was found with ALL subtype or risk ( P > 0.05 ). Although consanguinity and number of siblings have affected some variables and prognostic features of childhood ALL, the aetiology is not clear and we need further studies to clarify such an association as this will help in optimising therapy and accurately determine the risk.

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Section: Introductionmentioning

confidence: 99%

Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia

Kakaje

Alhalabi

Ghareeb

et al. 2020

BioMed Research International

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“… 1 , 5 – 14 However, there were some reports that described a negative association between consanguinity and risk of diseases. 15 – 17 A negative association was reported between the susceptibility to infection with HIV-1 and inbreeding coefficient. 17 Based on an ecologic study the mean of inbreeding coefficient (at the population level; α) is negatively associated with age-standardized mortality rate due to breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“… 15 – 17 A negative association was reported between the susceptibility to infection with HIV-1 and inbreeding coefficient. 17 Based on an ecologic study the mean of inbreeding coefficient (at the population level; α) is negatively associated with age-standardized mortality rate due to breast cancer. This means that the countries with a high level of consanguinity show a low level of age-standardized mortality rates due to breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Age-Standardized Incidence Rates for Leukemia Associated With Consanguineous Marriages in 68 Countries, an Ecological Study

Saadat

2015

Mediterr J Hematol Infect Dis

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Consanguineous marriage that defines as a union between biologically related persons has a variety of known deleterious correlations with factors that affect public health within human populations. To investigate the association between the mean of inbreeding coefficient (α) and incidence of leukemia, the present ecological study on 68 countries was carried out. Statistical analysis showed that the age-standardized incidence rate of leukemia positively correlated with log10GNI per capita (r=0.699, df=66, P<0.001) and negatively correlated with log10α (r=−0.609, df=66, P<0.001). Controlling log10GNI per capita, a significant negative correlation between log10α and the age-standardized incidence rate of leukemia was observed (r=−0.392, df=65, P=0.001). The countries were stratified according to their annual GNI per capita, low and high-income countries with GNI per capita less than and more than 10,000$, respectively. Statistical analysis showed that in high-income countries, after controlling for log10GNI per capita, the correlation between the age-standardized incidence rate of leukemia and log10α was still significant (r=−0.600, df=36, P<0.001). It should be noted that there was no significant association between the age-standardized mortality rate due to leukemia and log10α (P>0.05). The present finding indicates that the rate of leukemia, age-standardized for incidence, is lower in countries with a high prevalence of consanguineous marriages.

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“…Taken together it might be concluded that consanguinity has social advantages. On the other hand, consanguineous marriages are associated with increased risk of recessive traits and also it might be associated with many multifactorial diseases [4,[10][11][12][13][14]. However, activities for reduction of consanguinity which is culturally favored in population, without attention to its social reflections, are not recommended.…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of consanguinity is influenced by several factors including demographic, religious, cultural and socio-economic factors [4][5][6][7][8]. Many studies indicated that consanguineous marriages are associated with increased risk of recessive traits [9,10] and also it might be associated with many multifactorial diseases among their offspring [4,[10][11][12][13][14]. It should be noted that the associations between consanguineous marriages and susceptibility to multifactorial disorders are controversial.…”

Section: Introductionmentioning

confidence: 99%

Association between consanguinity and survival of marriages

Saadat

2015

Egyptian Journal of Medical Human Genetics

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Background and purpose: The present study was performed to investigate the association between consanguineous marriages and divorce risk.Materials and methods: A total of 496 couples at divorce time and 800 couples from general population who have no plan for divorce (as control group) were included in the study.Results: Compared to unrelated marriages, first cousin (OR = 0.39, 95% CI: 0.27-0.56, P < 0.001), first cousin once removed (OR = 0.18, 95% CI: 0.05-0.62, P = 0.006) and second cousin marriages (OR = 0.37, 95% CI: 0.17-0.78, P = 0.009) decreased the risk of divorce. The Cox proportional hazards regression analysis revealed that the survival of marriage was lower significantly for unrelated marriages than first cousin marriages, after adjusted for educational level (HR = 0.48, 95% CI: 0.35-0.67, P < 0.001).Conclusion: The present findings indicate that consanguinity has some protective role(s) against divorce and also survival of marriages increased among consanguineous marriages. Considering that divorce rate is affected by several factors, replication of present findings in other populations is recommended.Ó 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University.

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Association between inbreeding coefficient and susceptibility to HIV-1 infection, a case-control study

Cited by 4 publications

References 13 publications

Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia

Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia

Age-Standardized Incidence Rates for Leukemia Associated With Consanguineous Marriages in 68 Countries, an Ecological Study

Association between consanguinity and survival of marriages

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