Age-Standardized Incidence Rates for Leukemia Associated With Consanguineous Marriages in 68 Countries, an Ecological Study

Saadat, Mostafa

doi:10.4084/mjhid.2015.027

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…It's clear in the chart figure the patients which there is no consanguinity between their parents have a great percentage (85%) while the patients which their parents were relatives of each other show a low percentage (15%), this result is similar with results were obtained by (Saadat, 2015) who concluded from the study (Age-standardized Incidence Rates for Leukemia Associated with Consanguineous Marriages in 68 Countries) that Leukemia rates are smaller in nations where consanguineous marriages are highly prevalent.…”

Section: The Distribution Of Patients With Chronic Myeloidsupporting

confidence: 85%

Cytogenetic Study of Chronic Myeloid Leukemia in Erbil City Kurdistan Region of Iraq

Khudhu¹,

Ismaiel²,

Sulaiman³

2021

PLANT ARCHIVES

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Chronic myeloid leukemia is a rare form of cancer that affects blood cells and is characterized by a genetic mutation between chromosome (9) and chromosome ( 22) known by reciprocal t(9;22) (q34;q11) translocation, Which leads to composition of the chimerical fusion gene (BCR-ABL1) on chromosome (22), which is known after that by (Philadelphia chromosome). More than (90%) of chronic myeloid leukemia patients are diagnosed with presence of Philadelphia chromosome. The present study was carried out on (40) patients who were suffering from Chronic Myeloid Leukemia in Erbil city and (10) healthy individuals as a control group in both sex and different age groups. Blood samples were collected and chromosomal study was performed. The research concluded the effect of several factors, including that most cases were between the age group (41-50) and among males more than females. Also the percentage of illness in relation to the type of occupation was among most females who were housewives at (42%). As for the patients' living location, between inside and outside the city, the result was somewhat close to each other even when taking into consideration the proportion of males and females. As for the occurrence of types of chromosomal aberrations, the study showed that the highest value of chromosomal aberrations was in (Dicentric chromosome), specifically in females of the age group (41-50).

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Section: The Distribution Of Patients With Chronic Myeloidsupporting

confidence: 85%

Cytogenetic Study of Chronic Myeloid Leukemia in Erbil City Kurdistan Region of Iraq

Khudhu¹,

Ismaiel²,

Sulaiman³

2021

PLANT ARCHIVES

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“…The study demonstrated a very high level of consanguineous marriage among Iranian Mandaeans. It has been shown that consanguinity significantly increases the prevalence of inherited autosomal recessive diseases and many multifactorial traits such as infertility, congenital disorders, and mental retardation (Bittles et al, 1993;Bittles & Neel, 1994;Stoltenberg et al, 1999;Bittles, 2001;Saadat & Zendeh-Boodi, 2006;Saadat, 2008a;Tadmouri et al, 2009;Mansour et al, 2010;Saadat & Vakili-Ghartavol, 2010;Nafissi et al, 2010Nafissi et al, , 2011Anvar et al, 2011;Saadat, 2011Saadat, , 2015a. The harmful consequences of consanguineous mating emphasize the need for genetic counselling in the Mandaean community and the importance of preventive action to raise awareness about the risks of consanguinity.…”

Section: Resultsmentioning

confidence: 99%

“…Considering that consanguinity results in homozygosity in offspring, it is associated with an elevation in the risk of autosomal recessive disease and several multifactorial complex traits (Bittles & Neel, 1994;Stoltenberg et al, 1999;Bittles, 2001;Saadat & Zendeh-Boodi, 2006;Saadat, 2008a;Tadmouri et al, 2009;Mansour et al, 2010;Saadat & Vakili-Ghartavol, 2010;Nafissi et al, 2010Nafissi et al, , 2011Anvar et al, 2011;Saadat, 2011Saadat, , 2015a.…”

Section: Introductionmentioning

confidence: 99%

Consanguineous Marriages Among Iranian Mandaeans Living in South-West Iran

Saadat

Zarghami

2017

J. Biosoc. Sci.

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SummarySeveral studies have indicated that consanguineous marriages (unions between biologically related persons) are associated with increased risk of autosomal recessive diseases and several multifactorial traits. Mandaeans are a closed ethno-religious community living in areas of southern Iraq and Iran (Khuzestan Province). There are currently no data on the prevalence of consanguineous marriages among Mandaeans. The present study was carried out in 2016 to determine the prevalence of consanguinity among Iranian Mandaeans living in Khuzestan Province, south-west Iran. A total of 137 couples (urban areas: 79 couples; rural areas: 58 couples) were included in the study. Information on the consanguineous marriages of the subjects was collected through direct interviews. Marriages were classified by the degree of relationship between couples as double first cousins, first cousins, first cousin once removed, second cousins and unrelated marriages. The coefficient of inbreeding (F) was calculated for each couple and the mean coefficient of inbreeding (α) estimated for the population, stratified by rural and urban areas. The overall frequency of consanguinity was found to be 50.7% in urban and 86.2% in rural areas. There was a significant difference between rural and urban areas in types of marriages (χ 2=24.8, df=4, p<0.001) and first cousin marriages (51.8%) were the most common type. The overall α-value was estimated to be 0.0363 for the Iranian Mandaean population.

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“…It is well established that genetic components are involved in increasing the risk of developing leukemia. For this reason, the familial relationship of parents increases the children's homozygosity and increases the risk of cancer (27). Mehrvar et al reported that 41% of parents of children with leukemia had a familial relationship (28) and Bener et al's study showed the rate of leukemia and lymphoma in children of parents with a familial relationship was higher than in the unrelated group (29).…”

Section: Discussionmentioning

confidence: 99%

Parametric Models for Survival Analysis of Childhood Cancer Patients' Data

et al. 2022

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Background:The rate of childhood cancer death has dropped steadily over the past 50 years. The pediatric cancer risk has remained under investigation. Objectives: This study aims at investigating the associated factors with the survival of pediatric patients with retinoblastoma, sarcoma, brain tumor, and leukemia cancer. Methods: The cohort study of 1879 children with retinoblastoma, sarcoma, brain tumor, and leukemia aged < 1, 1 -5, 6 -10, 11 -15, and > 15 years in Mahak Hospital and Rehabilitation Complex from 2007 to 2016 were enrolled in the study. Median survival time was reported for each cancer. Parametric survival models including Gompertz, Weibull, lognormal, and log-logistic models were fitted. Then, the model with almost minimum Akaike information criterion (AIC) was chosen. The hazard ratio (HR) and the analysis were performed by R3.5.1. Results: Totally, 270 (14.37%) patients with Retinoblastoma, 667 (35.5%) with leukemia, 625 (33.26%) with a Brain tumor, and 317 (16.87%) with Sarcoma were included in this study; 815 (43.37%) patients were female. Gompertz's model was chosen to fit the data due to the minimum AIC. The associated factors with the survival of childhood cancers were as follows: age < 1 year, parental relation, locoregional relapse and chemotherapy alone (HR: 7.63, 1.56, 4.61, 1.12) in leukemia, other nationalities, metastasis or metastasis and loco-regional relapse and chemotherapy alone (HR = 3.74, 5.75, 2.12) in retinoblastoma, loco-regional relapse and metastasis (HR = 2.40, 3.71) in brain tumor, other ages except for 5 -10 years, parental relation, chemotherapy alone, and metastasis (HR = 33.3, 1.80, 3.57, 3.8) in sarcoma. Conclusions: Age, parental familial relationships, combination therapy, and metastasis of primary cancer were the risk factors for survival of children with 4 common cancers of leukemia, retinoblastoma, brain tumors, and sarcoma, using the Gompertz model.

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Age-Standardized Incidence Rates for Leukemia Associated With Consanguineous Marriages in 68 Countries, an Ecological Study

Cited by 3 publications

References 30 publications

Cytogenetic Study of Chronic Myeloid Leukemia in Erbil City Kurdistan Region of Iraq

Cytogenetic Study of Chronic Myeloid Leukemia in Erbil City Kurdistan Region of Iraq

Consanguineous Marriages Among Iranian Mandaeans Living in South-West Iran

Parametric Models for Survival Analysis of Childhood Cancer Patients' Data

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